The prognostic significance of serum aspartate transaminase and gamma‐glutamyl transferase in liver deceased donors

Abstract

The impact of aspartate transaminases (AST) and gamma‐glutamyl transferase (GGT) in serum of deceased donors on outcomes after liver transplantation (LT) is unclear. This study aimed to explore the relationship between donor highest AST value or first donor GGT value and graft survival. All consecutive patients who underwent a primary LT in a single center with available donor AST (N = 1253) and GGT value (N = 1152) were included. There was no significant association between donor AST and 90‐day graft survival. We found a moderate association between GGT and 90‐day graft survival. We found a significant interaction with a donor history of alcohol abuse (HAA). The risk of graft loss was associated with AST and GGT in donors with an HAA but remains unchanged in donors without HAA. There was no difference in graft survival according to donor AST or GGT with a cutoff ≥95th percentile (475 UI/l for AST and 170 UI/l for GGT). However, graft survival was significantly decreased when donors combined GGT ≥ 170 UI/l and HAA (61% at one year). Hepatic grafts from donors with high AST or high GGT but without alcohol history and no additional risk factors can be transplanted in low‐risk recipient.

Bicarbonate ringer’s solution could improve the intraoperative acid-base equilibrium and reduce hepatocellular enzyme levels after deceased donor liver transplantation: a randomized controlled study

“…Previous studies have shown that 7-day AST values were negatively correlated with long-term graft liver function and patient survival in LT. This study also found that the creatinine values of the two groups at 30 days after surgery were 90.2 ± 22.5 µmol/L and 82.2 ± 16.3 µmol/L, respectively, with a significant difference ( P = 0.019); this result is in line with those of other reports [ 24 ]. However, since the results of this study were only for secondary outcomes and the sample size was small, their significance needs to be further verified.…”

Bicarbonate Ringer’s solution could improve the intraoperative acid-base equilibrium and reduce hepatocellular enzyme levels after liver transplantation: A randomized controlled study

“…Previous studies have shown that 7-day AST values were negatively correlated with long-term graft liver function and patient survival in LT. This study also found that the creatinine values of the two groups at 30 days after surgery were 90.2 ± 22.5 µmol/L and 82.2 ± 16.3 µmol/L, respectively, with a signi cant difference (P = 0.019); this result is in line with those of other reports [23] .…”

Donor Liver Blood Tests and Liver Transplant Outcomes: UK Registry Cohort Study

“…29,30 Also, a single-center French study (1438 recipients between 2004 and 2018) found no significant impact of either AST or GGT on 1-y graft survival, whereas ALT was not examined. 31 The present study is the first large, multicenter cohort study outside of the United States that focuses on donor LBTs and outcome.…”