The prognostic significance of nutritional status using malnutrition universal screening tool in patients with pulmonary tuberculosis

Miyata, Seiko; Tanaka, Mikio; Ihaku, Daizo

doi:10.1186/1475-2891-12-42

Cited by 40 publications

(33 citation statements)

References 16 publications

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“…Several studies reported that patients with active pulmonary tuberculosis are under or malnourished. 41,42 It is further reported that age as well as nutritional status significantly influences the isoniazid acetylator status as well as drug levels in tuberculosis subjects. 30 Hence, nutritional support is needed for undernourished tuberculosis subjects.…”

Section: Discussionmentioning

confidence: 99%

Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity

Jatav

Kulshrestha

Zacharia

et al. 2014

J Evid Based Complementary Altern Med

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Hepatotoxicity associated with isoniazid and rifampicin is one of the major impediments in antituberculosis therapy. The present study explored the prophylactic and therapeutic efficacies of Spirulina maxima in isoniazid and rifampicin induced hepatic damage in a rat model. Hepatic damage induced in Wistar rats by isoniazid and rifampicin resulted in significant alterations in biomarkers of liver function, namely, bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, and oxidative stress markers such as superoxide dismutase, catalase, glutathione, and thiobarbituric acid reactive substances. Co-administration of Spirulina maxima along with antituberculosis drugs protected liver from hepatotoxicity due to isoniazid and rifampicin. Administration of Spirulina maxima consecutively for 2 weeks to hepatodamaged animals resulted in restoration of hepatic function as evident from normalization of serum markers of liver function. Thus, the present study revealed remarkable prophylactic and therapeutic potential of Spirulina maxima. Co-administration of Spirulina maxima and antituberculosis drugs is advantageous as it provides extra nutritional benefit.

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Section: Discussionmentioning

confidence: 99%

Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity

Jatav

Kulshrestha

Zacharia

et al. 2014

J Evid Based Complementary Altern Med

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“…Nutritional status has been shown to be a predictor of outcomes for some pulmonary diseases such as chronic obstructive pulmonary disease (COPD) [7] or tuberculosis [8]. For these diseases, an unbalanced nutritional status is associated with a poorer outcome.…”

Section: Introductionmentioning

confidence: 99%

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

et al. 2018

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Background: The significance of the nutritional status in idiopathic pulmonary fibrosis (IPF) is largely unknown. Temporal body weight (BW) change, a dynamic index of nutrition status, can detect the malnutrition more accurately than the conventional single-point body mass index evaluation. Objective: To investigate how the temporal BW change influences the clinical courses of IPF. Methods: This multicenter study enrolled IPF patients from four referral hospitals of interstitial lung diseases in Japan (the Japanese cohort, the derivation cohort) and the Royal Brompton Hospital (the UK cohort, the validation cohort). The annual rate of BW change from the initial presentation was evaluated. A > 5% decrease of BW was defined as a significant BW loss. Results: Twenty-seven out of 124 patients in the Japanese cohort and 13 out of 86 patients in the UK cohort showed significant BW loss. Patients with BW loss showed significantly worse survival in both cohorts. Multivariate analyses revealed that BW loss was an independent factor for decreased survival (Japanese cohort: p = 0.047, UK cohort: p = 0.013). A 6.1% loss of BW was chosen as the optimal cutoff value to predict the 2-year mortality from the initial presentation. The stratified analysis revealed that a 6.1% or greater BW loss could predict worse survival specifically in cases without a greater than 10% decline in forced vital capacity (FVC). Conclusions: BW loss is independently associated with the survival of IPF patients, particularly when a decline in the FVC was not observed. Further studies are needed to understand the mechanisms underlying BW loss in IPF.

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“…Este achado sugere que a alimentação de pacientes com TB pulmonar apresentava possíveis deficiências nutricionais, as quais podem gerar implicações no processo de tratamento e recuperação do estado de saúde. 4 Em relação às variáveis sociodemográficas, os resultados demonstram o predomínio da TB pulmonar em pacientes do sexo masculino (62,2%), concordante com outros estudos, tendo em vista a maior exposição a fatores de risco, menor procura pelos serviços de saúde e aos hábitos culturais relacionados ao comportamento masculino em situações de adoecimento.…”

Section: Discussionunclassified

“…3 A relação entre TB pulmonar e nutrição tem sido apontada como um aspecto importante para a efetividade da resposta imunológica do hospedeiro à doença. 4 Na medida em que pode ocorrer o catabolismo proteico, ativação de citocinas e modificações no sistema imune e trato gastrointestinal, ocasionando a desnutrição e/ou carências nutricionais. 5 A desnutrição constitui importante indicador quanto ao risco de contrair a TB e pode também influenciar na eficiência do tratamento, considerando que a administração dos medicamentos padronizados pode provocar efeitos adversos, entre eles alterações hepáticas e gastrointestinais.…”

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Hábito alimentar e perfil sociodemográfico de pacientes com tuberculose pulmonar.

Frazão

Dias

Sousa

et al. 2017

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. anos (42,6%) e nível de escolaridade de 10 a 12 anos de estudo (42,6%). Houve associação estatisticamente significativa para o consumo dos três marcadores (p<0,00), bem como entre o sexo e o consumo recomendado de peixe (p=0,00). Conclusão: O hábito alimentar de marcadores de alimentação saudável abaixo da frequência recomendada pode modificar o perfil nutricional do paciente de TB pulmonar e facilitar a infecção e as consequências da doença. Descritores: Dieta Saudável. Tuberculose Pulmonar. Prevenção de Doenças.Background and Objectives: Tuberculosis (TB) is an infectious disease that may be more susceptible in people with nutritional deficiencies. The objective of this study was to investigate dietary markers and their association with sociodemographic variables of patients with pulmonary TB. Methods: A cross-sectional descriptive study carried out in between 2015 and 2016 in Belém-PA. TB patients were interviewed using a questionnaire developed based on the National Health Survey, with questions about socio-demographic and variables healthy food markers. Data were analyzed in the Epi-Info and Bioestat programs, using the G and Binomial tests, with a significance level of 5%. Results: 61 patients participated in the study, most of them male (62.2%), 40-59 years old (42.6%) and 10 to 12 years of schooling (42.6%). There was a statistically significant association for the consumption of the three markers (p <0.00), as well as between sex and recommended fish consumption (p =0.00). Conclusion: The eating habits of healthy food markers below the recommended frequency can modify the patient's nutritional profile of TB pulmonary patient and to facilitate the infection and the consequences of the disease.

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The prognostic significance of nutritional status using malnutrition universal screening tool in patients with pulmonary tuberculosis

Cited by 40 publications

References 16 publications

Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity

Spirulina maxima Protects Liver From Isoniazid and Rifampicin Drug Toxicity

The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

Hábito alimentar e perfil sociodemográfico de pacientes com tuberculose pulmonar.

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