The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma

Oktay, Esin; Oflazoğlu, Utku; Varol, Yelda; Tanrıverdi, Özgür; Mermur, Necla; Arda, Hayri Ustun; Demir, Lutfiye; Keskin, Özge; Ahmadli, Tural; Somali, İşıl; Öztop, İlhan; Meydan, Nezih

doi:10.4103/jcrt.jcrt_1404_16

Cited by 11 publications

(8 citation statements)

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“…Lung adenocarcinoma is one of the leading causes of cancer death and accounted for nearly 40% of all lung cancers 1 . In recent years, the incidence of lung adenocarcinoma is on the rise in many countries 2 . Accurate diagnoses and discrimination between lung adenocarcinoma and reactive bronchial epithelium for lung adenocarcinoma are of vital importance for optimal therapeutic decision-making and improved prediction of patients’ response to treatment 3 .…”

Section: Introductionmentioning

confidence: 99%

The Morphological Analysis of Cells in the Bronchoscopic Brushing and TBNA of Patients with Lung Adenocarcinoma

et al. 2020

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Biopsy, brushing, and transbronchial needle aspiration (TBNA) are the most common methods for diagnosis of lung adenocarcinoma and are taken during the same diagnostic bronchoscopic procedure. However, it is not clear what the morphological diagnostic criteria of cytology by brushing or TBNA are. A retrospective analysis was performed on 136 patients who underwent video bronchoscopy examination for diagnostic purposes. All the subjects were performed brushing or TBNA and confirmed as lung adenocarcinoma by biopsy or postoperative pathology. An additional 140 randomly selected patients with benign lung diseases were included in the study and used as a control group. The benign cells usually confused with adenocarcinoma cells were ciliated columnar cells, mucous columnar cells, ciliated cuboid cells, and reactive ciliated cells, respectively. The number of cases diagnosed as adenocarcinoma cells, carcinoma cells, suspicious cancer cells, and atypical proliferative cells by cytology was 101, 11, 20, and 4, respectively. The main basis for the interpretation of adenocarcinoma cells is the enlargement of individual nucleus, the arrangements of multistage papillary, and the general enlargement of nuclei, while the main clue for the interpretation of suspicious cancer cells and dysplasia cells comes from escape cells. The results suggested that the degree of nuclear enlargement, multiple papillary arrangement, and escape cells or escape trend cells are important clues for the interpretation of lung adenocarcinoma cells, while the atypical proliferative cells were similar to escape cells or escape trend cells, which were essentially benign cells beside the cancer.

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Section: Introductionmentioning

confidence: 99%

The Morphological Analysis of Cells in the Bronchoscopic Brushing and TBNA of Patients with Lung Adenocarcinoma

et al. 2020

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“…In addition, when TSH binds to the thyroid-stimulating hormone receptor on the cell surface, it couples with the alpha subunit of the G protein on the cell e Human TTF-1 protein is detedted by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the unclei of epithelial cells of the developing airways. Guazzi S, et al [2] 1990 1995 2005 2007-2008 2017 2019…”

Section: The Regulation Of Ttf-1 Expressionmentioning

confidence: 99%

“…Thyroid transcription factor 1 (TTF-1) is a tissue-specific transcription factor with homeodomain protein folding structure, which is mainly expressed in differentiated cells derived from the foregut endoderm and neuroectoderm, including thyroid follicular cells and type II alveolar epithelial cells, and regulates the expression of relevant functional genes in the thyroid and lung tissues, promotes the development and differentiation of embryonic, and plays a key role in maintaining the normal function of terminal respiratory unit cells, especially as one of the molecular markers for the diagnosis of thyroid and lung tumors, indicating its good application value in the clinical differential diagnosis of thyroid or lung tumors [ 1 , 2 ]. Recent studies have also revealed that TTF-1 is also expressed in the pituitary gland, hypothalamus, and other diencephalic tissues, which participates in the development and biological function of the brain tissue, reflecting the complexity of its biological function ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Transcription Factor-1: Structure, Expression, Function and Its Relationship with Disease

Guan

Zhao

Tang

et al. 2021

BioMed Research International

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Thyroid transcription factor-1 (TTF-1/NKx2.1) is a member of the NKx2 tissue-specific transcription factor family, which is expressed in thyroid follicle, parathyroid gland, alveolar epithelium, and diencephalon which originated from ectoderm, and participates in the differentiation, development, and functional maintenance of the above organs. Recent studies have shown that the abnormal expression of TTF-1 is closely related to the occurrence of a variety of human diseases and can be used as a potential new target for the diagnosis and treatment of related diseases. In this article, in order to strengthen the systematic understanding of TTF-1 and promote the progress of related research, we reviewed the structure, expression regulation, biological functions of TTF-1, and its role in the occurrence and development of human-related clinical diseases. Meanwhile, we prospect the future research direction of TTF-1, which might ultimately contribute to the understanding of the pathogenesis of related clinical diseases and the development of new prevention and treatment strategies.

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“…For instance, Edwards et al revealed that ZEB1 serves as a TF that is prognostic and predictive in diffuse gliomas [6]. Oktay et al indicated that thyroid TF-1 plays a key role in lung adenocarcinoma prognosis [7]. Tang et al suggested that FOXO1 inhibits prostate cancer cell progression by suppressing E2F1-activated NPRL2 expression [8].…”

Section: Introductionmentioning

confidence: 99%

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

Li¹,

Guo²,

Yin³

et al. 2023

J. Cancer

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Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Transcription factors (TFs) are essential gene expression regulators, and play critical roles in cancer development. However, the biological actions and prognostic value of TFs in GC remain unclear. In this study, we identified a risk model based on a 14-TF signature to predict recurrence-free survival in patients with GC. We further analyzed the ability of 14-TF to predict recurrence-free survival time in GC and found that a higher expression level of metastasis-associated protein 2 (MTA2) was associated with shorter overall survival and disease-free survival time in GC. Through in vitro and in vivo experiments, we demonstrated that MTA2 significantly promotes GC growth and metastasis. Furthermore, we identified MTA2 binding to the promoter of minichromosome maintenance deficient 5 (MCM5), thereby promoting GC progression. Overall, these findings strongly support the prognostic potential of the 14-TFs signature and suggest that targeting MTA2 may be a promising strategy to treat GC.

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The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma

Cited by 11 publications

References 0 publications

The Morphological Analysis of Cells in the Bronchoscopic Brushing and TBNA of Patients with Lung Adenocarcinoma

The Morphological Analysis of Cells in the Bronchoscopic Brushing and TBNA of Patients with Lung Adenocarcinoma

Thyroid Transcription Factor-1: Structure, Expression, Function and Its Relationship with Disease

MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5

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