The prognostic role of preoperative serum C-reactive protein in predicting the biochemical recurrence in patients treated with radical prostatectomy

Sevcenco, Sabina; Mathiéu, Romain; Baltzer, Pascal; Klatte, Tobias; Fajković, Harun; Seitz, Christian; Pi, Karakiewicz; Rouprêt, Morgan; Rink, Michael; Kluth, Luis A.; Trinh, Q-D.; Loidl, Wolfgang; Briganti, Alberto; Scherr, Douglas S.; Sf, Shariat

doi:10.1038/pcan.2015.60

Cited by 12 publications

(8 citation statements)

References 31 publications

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“…In particular, we focused attention to the levels of BIRC5, PSA, SRD5A2, MMP2 CRP and SOD2 genes, known to be involved in PCa initiation and progression [38–41], and associated with inflammatory [42] and oxidative stress conditions. The results showed an increase of the MMP2 , BIRC5, CRP and SOD2 expression in samples characterized by high Gleason Score.…”

Section: Resultsmentioning

confidence: 99%

Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score

et al. 2017

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Prostate Cancer (PCa) is a complex and heterogeneous disease. The androgen receptor (AR) and the signal transducer and activator of transcription 3 (STAT3) could be effective targets for PCa therapy. STAT3, a cytoplasmatic latent transcription factor, is a hub protein for several oncogenic signalling pathways and up-regulates the expression of numerous genes involved in tumor cell proliferation, angiogenesis, metastasis and cell survival. STAT3 activity can be modulated by several Post-Translational Modifications (PTMs) which reflect particular cell conditions and may be implicated in PCa development and progression. The aim of this work was to analyze STAT3 PTMs at different tumor stages and their relationship with STAT3 cellular functions. For this purpose, sixty-five prostatectomy, Formalin-fixed paraffin-embedded (FFPE) specimens, classified with different Gleason Scores, were subjected to immunoblotting, immunofluorescence staining and RT-PCR analysis. All experiments were carried out in matched non-neoplastic and neoplastic tissues. Data obtained showed different STAT3 PTMs profiles among the analyzed tumor grades which correlate with differences in the amount and distribution of specific STAT3 interactors as well as the expression of STAT3 target genes. These results highlight the importance of PTMs as an additional biomarker for the exactly evaluation of the PCa stage and the optimal treatment of this disease.

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Section: Resultsmentioning

confidence: 99%

Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score

et al. 2017

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“…Similarly, patients with elevated preoperative CRP were more likely to have extracapsular extension, seminal vesicle invasion, lymph node metastasis, positive surgical margins, and biochemical recurrence (23). Although elevated postoperative CRP was associated with adverse pathologic outcomes and higher rates of 5-year biochemical recurrence, the addition of CRP to established pre-operative modeling for BCR did not improve predictive modeling over the traditional characteristics alone (23,52). As such, CRP likely has limited utility for outcome prediction after RP.…”

Section: Crp In Prostate Cancermentioning

confidence: 95%

“…Limited data exists regarding CRP in the setting of localized prostate cancer treated with radical prostatectomy (RP). In a retrospective, multi-institutional study of 7,426 patients who underwent RP, pre-prostatectomy CRP levels were associated with pathologic Gleason score, but not tumor stage (22,23). Similarly, patients with elevated preoperative CRP were more likely to have extracapsular extension, seminal vesicle invasion, lymph node metastasis, positive surgical margins, and biochemical recurrence (23).…”

Section: Crp In Prostate Cancermentioning

confidence: 96%

“…In a retrospective, multi-institutional study of 7,426 patients who underwent RP, pre-prostatectomy CRP levels were associated with pathologic Gleason score, but not tumor stage (22,23). Similarly, patients with elevated preoperative CRP were more likely to have extracapsular extension, seminal vesicle invasion, lymph node metastasis, positive surgical margins, and biochemical recurrence (23). Although elevated postoperative CRP was associated with adverse pathologic outcomes and higher rates of 5-year biochemical recurrence, the addition of CRP to established pre-operative modeling for BCR did not improve predictive modeling over the traditional characteristics alone (23,52).…”

Section: Crp In Prostate Cancermentioning

confidence: 99%

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The Role of C-Reactive Protein in Kidney, Bladder, and Prostate Cancers

et al. 2021

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C-Reactive Protein (CRP) is associated with diverse outcomes in patients with, or suspected to have, genitourinary malignancies. CRP levels have been shown to be associated with the probability of a prostate cancer diagnosis in patients with elevated PSA, the probability of biochemical recurrence following definitive treatment for localized prostate cancer, and decreased overall survival for patients with advanced disease. In patients with bladder and kidney cancers, CRP levels have been associated with disease progression, stage, and cancer-specific survival. Despite the abundance of correlative studies, the relationship between CRP levels and genitourinary cancer pathogenesis is not clearly understood. Here, we review the evidence for CRP as a biomarker in genitourinary (GU) cancers, with specific focus on potential clinical applications.

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“…C-reactive protein (CRP), an acute phase reactant that is elevated in IBD, was also associated with higher PSA levels [32][33][34]. In fact, higher CRP levels were found to correlate with PCa resistance to treatment and poorer survival [34,35].…”

Section: Inflammatory Statementioning

confidence: 99%

Inflammatory bowel disease and prostate cancer risk: A systematic review

Haddad

Al-Sabbagh

Al-Ani

et al. 2020

Arab Journal of Urology

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Objective: To evaluate the risk of prostate cancer (PCa) in patients with inflammatory bowel disease (IBD), focussing on ulcerative colitis (UC) and Crohn's disease (CD) separately. Methods: A systemic search was carried out using PubMed and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We retrieved a total of 349 articles. All the articles were in the English language and investigated the incidence of PCa in patients with IBD. Results: Nine studies met our inclusion criteria, with a total of 205 037 men. Two studies reported an increase in the risk of PCa in men with IBD in general. Five other studies reported an increased risk of PCa in men with UC or with CD specifically. On the other hand, two studies reported a decreased risk of PCa in patients with UC and patients with IBD treated with aminosalicylates. Conclusions: While men with UC appear to have higher risk of developing PCa, data on patients with CD are inconclusive. Therefore, patients with UC may benefit from earlier PCa screening. Our findings confirm a complex interplay between IBD and PCa, including factors such as genetic predisposition, systemic inflammation and treatment effects. The modulatory effect of treatment strategies for IBD on the development and progression of PCa might be of clinical significance.

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The prognostic role of preoperative serum C-reactive protein in predicting the biochemical recurrence in patients treated with radical prostatectomy

Abstract: Preoperative CRP is elevated in patients with pathological features of aggressive PCa and BCR after RP. While CRP has independent prognostic value, it does not add prognostically or clinically significant information to standard predictors of outcomes.

Cited by 12 publications

References 31 publications

Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score

Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score

The Role of C-Reactive Protein in Kidney, Bladder, and Prostate Cancers

Inflammatory bowel disease and prostate cancer risk: A systematic review

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