The prognostic role of preoperative systemic immune-inflammation index and albumin/globulin ratio in patients with newly diagnosed high-grade glioma

Liang, Ruofei; Li, Junhong; Tang, Xiaoping; Liu, Yan‐Hui

doi:10.1016/j.clineuro.2019.105397

Cited by 33 publications

(39 citation statements)

References 37 publications

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“…In addition, the inflammation scores such as NLR, dNLR, and PLR were markedly upregulated in high-grade gliomas, which were consistent with the results of previous studies (6,42,43). Regardless, the serum sPD-L1 levels failed to yield any significant associations with systemic inflammatory markers in the glioma patients (Tables 2, 3).…”

Section: Discussionsupporting

confidence: 89%

The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas

et al. 2020

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Background: Soluble PD-L1 (sPD-L1) in the circulation has been documented to activate global immunosuppression and is considered a predictor of negative clinical outcomes in several malignances. However, the clinical significance of sPD-L1 in the peripheral blood and cerebrospinal fluid (CSF) of patients with glioma remains unclear. Objective: The aim of this study was to detect the correlations of sPD-L1 with clinical features in brain tumors and assess the diagnostic value of this protein in gliomas. Methods: Serum samples were obtained from 73 patients with glioma, 20 patients with meningioma, and 49 healthy controls (HCs) in this study. In total, 31 CSF samples were collected from the matched glioma patients, and seven samples were collected from the matched meningioma patients. The expression of serum sPD-L1 in the glioma cohort was followed for 20 days after surgery to examine the kinetics in the circulation. Inflammatory markers were evaluated based on preoperative blood parameters. The sPD-L1 levels in the serum and CSF were determined by enzyme-linked immunosorbent assay (ELISA). The logistic regression model was used to assess the independent associations of sPD-L1 with gliomas, including high-grade gliomas. Results: Serum and CSF levels of sPD-L1 were significantly elevated in patients with gliomas compared to those with meningiomas and HCs. Additionally, increased levels of sPD-L1 were observed in relatively advanced tumors. sPD-L1 overexpression in the CSF appears to be more representative of aggressive tumor features than overexpression in the serum. For glioma diagnosis, both serum and CSF sPD-L1 showed significant value in the diagnosis and stratification of glioma, and the best diagnostic performance was obtained with serum sPD-L1 rather than blood-based inflammatory markers. In addition, a descending trend in the level of serum sPD-L1 was observed in postoperative patients. Conclusion: In gliomas, elevated circulating and CSF sPD-L1 levels are associated with aggressive biological activities. The results of the current study suggest that sPD-L1 is a promising biomarker for gliomas that can be used in clinical practice.

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Section: Discussionsupporting

confidence: 89%

The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas

et al. 2020

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“…Among these 11 studies, the study of Han et al [ 9 ] contained 2 multivariate analysis results due to different adjusted variables; the study of He et al [ 19 ] included the training and validation cohorts for prognosis analysis; the study of Wang e al [ 10 ] independently analyzed all the gliomas and GBM samples; thus, in fact, 14 datasets were used for this meta-analysis. Seven studies with 9 datasets [ 9 – 15 ] assessed the prognostic value of serum albumin on OS; 5 studies with 6 datasets [ 10 , 11 , 15 – 17 ] investigated the association between AGR and OS; 7 studies with 9 datasets [ 10 , 12 – 14 , 18 – 20 ] focused the predictive ability of PNI for OS; and 1 study with 2 datasets reported the relationship between PNI and PFS. [ 19 ] Six studies evaluated patients belonging to GBM (IV), 2 evaluated high-grade patients (III-IV), 1 focused on low-grade cases (II-III), and 3 studies evaluated all glioma types (I-IV).…”

Section: Resultsmentioning

confidence: 99%

“…This hypothesis had been confirmed in the study of Han et al [ 9 ] and Wang et al [ 10 ] However, there were also some contradictory conclusions, showing no significant associations between serum albumin level and OS in patients with glioma. [ 11 – 15 ] These inconsistent results may be attributed to 2 aspects:…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Liu¹,

Wang²

2020

Medicine

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Background: The serum albumin, albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI) have been recommended to represent the nutritional and inflammatory status. Thus, they may be potential prognostic biomarkers for cancer. However, contradictory results were reported in different studies on glioma. The goal of this study was to perform a meta-analysis to re-evaluate their prognostic potential for glioma. Methods: Databases of PubMed, EMBASE, and Cochrane Library were systematically searched to enroll all the studies investigating the prognostic significance of albumin, AGR, and PNI for glioma. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using STATA 13.0 software to indicate the intensity of association. Results: Eleven studies with 2928 cases were included. Overall meta-analysis showed that the prognostic values of albumin, AGR, and PNI were limited for glioma ( P > .05). However, subgroup analysis demonstrated a high preoperative serum albumin was significantly related with excellent OS of patients with GBM (HR = 0.95, 95% CI: 0.91–0.99, P = .018), while high PNI (HR = 0.56, 95% CI: 0.43–0.73, P < .001) and AGR (HR = 0.57, 95% CI: 0.34–0.96, P = .034) may be a protective factor of favorable OS for patients with high-grade gliomas. Furthermore, integration of all studies with multivariate analysis and clear cut-off also proved reduced preoperative serum albumin, AGR, and PNI were predictors of poor prognosis for patients with gliomas. Conclusion: Preoperative serum albumin, AGR, and PNI may represent promising biomarkers to predict the prognosis in patients with glioma, especially for high-grade.

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“…As inflammation can stimulate granulopoiesis or thrombopoiesis, inflammatory indexes such as leukocytosis, neutrophilia, thrombocytosis, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) can serve as significant prognosticator in patients with solid malignancies including endometrial cancer [14,15]. Recently, a novel inflammatory index, the systemic immune-inflammation index (SII) based on peripheral neutrophil, platelet, and lymphocyte counts, was been found to be an useful prognosticator in cancer patients [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. However, the prognostic significance of SII in endometrial cancer patients or its relative utility when compared with other inflammatory indexes has not been fully investigated [31,32].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of pre-treatment systemic immune-inflammation index in patients with endometrial cancer

et al. 2021

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Background The systemic immune-inflammation index (SII), which is calculated using absolute platelet, neutrophil, and lymphocyte counts, has recently attracted attentions as a prognostic indicator in patients with solid malignancies. In the current study, we retrospectively investigated the prognostic significance of pre-treatment SII among patients with endometrial cancer. Method Endometrial cancer patients treated at Nara medical university hospital between 2008 and 2018 were included in the current study. Receiver operating characteristic (ROC) curve was used to find the optimal SII cut-off values for 3-years progression free survival (PFS) and overall survival (OS). Then, the predictive abilities of SII and its superiority over neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were investigated. Kaplan-Meier method was used to calculate the OS and PFS rates, and log-rank test was used to compare the survival rate between two groups. Univariate and multivariate Cox regression analysis were performed to identify risk factors for PFS and OS. Result A total of 442 patients were included in the current study. The cut-off value of SII for predicting PFS and OS were defined by ROC analysis as 931 and 910, respectively. Univariate analyses showed that elevated SII was associated with significantly shorter survival (p <0.001 for both PFS and OS). Cox regression analyses revealed that an advanced FIGO stage (p <0.001 for both PFS and OS) and an elevated SII (p = 0.014 for PFS, p = 0.011 for OS) are the independent prognostic factors for survival. When SII was compared with NLR and PLR, SII showed greater area under curve for predicting survival. Conclusion The SII is an independent prognostic factor in endometrial cancer patients, allowing more precise survival estimation than PLR or NLR.

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The prognostic role of preoperative systemic immune-inflammation index and albumin/globulin ratio in patients with newly diagnosed high-grade glioma

Cited by 33 publications

References 37 publications

The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas

The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas

Prognostic significance of preoperative serum albumin, albumin-to-globulin ratio, and prognostic nutritional index for patients with glioma

Prognostic value of pre-treatment systemic immune-inflammation index in patients with endometrial cancer

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