The prognostic role of phospho-Src family kinase analysis in tongue cancer

Abstract

Inverse correlation between phospho-Src family kinase and patient survival demonstrates the prognostic role of phospho-Src family kinase in tongue cancer. These findings suggest a novel link between phospho-Src family kinase and TUNEL and c-erbB-2 pathways, tilting the balance toward cell proliferation.

FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival

“…In this context, taking into consideration that FAK and Src have been implicated in the regulation of tumor aggressiveness, it could be speculated that less aggressive tumors need more the ample expression of these enzymes in order to overcome the barriers for their survival, invasion, and metastasis. Moreover, an important observation of the present study was the significant association of Src expression with overall and disease-free patient survival in accordance with previous reports (Ben-Izhak et al 2010;Cheng et al 2011). This observation supports the potential role of Src signaling pathway in the disease progression, including aspects that may affect patients' survival.…”

“…Importantly, a recent immunohistochemical study by Ben-Izhak et al (2010) conducted on 39 mobile tongue SCC cases showed for the first time that Src expression was significantly correlated with lymph node metastasis and patients' survival and borderline with tumor size and stage. Moreover, Src was significantly associated with the progression, recurrence, and prognosis of oral SCCs in Taiwan (Cheng et al 2011).…”

“…However, regarding the role of these molecules in mobile tongue SCC, the existing data are still scarce (Jiang et al 2010;Ben-Izhak et al 2010;Cheng et al 2011).…”

The Prognostic Significance of Src and p-Src Expression in Patients with Osteosarcoma

“…A number of animal and cell experiments have confirmed that Src and p-Src can be detected in osteosarcoma cells [20–22], and in other malignant tumors such as squamous cell carcinoma of the tongue, breast cancer, rhabdomyosarcoma, and Ewing’s sarcoma, Src and p-Src also showed high expression [17,18,26–28]. In this study, we used immunohistochemistry to show that the expression percentage of Src and p-Src was 20% and 10% of the 20 osteochondroma cases, respectively, while in 116 cases of osteosarcoma, the expression rate of both proteins was significantly increased, with 62.9% and 64.7% of cases showing high expression of Src and p-Src, respectively.…”

Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection

“…10,11) SFKs, including Fyn, are non-receptor tyrosine kinases that drive malignancy in various cancers. 12,13) Fyn has also been suggested to be an effector of epidermal growth factor receptor (EGFR) signaling, 14,15) and it is recognized as a potential therapeutic target. 11,16,17) However, little is known about the clinical importance of phosphorylated Fyn (pFyn) in lung adenocarcinoma.…”