The prognostic relevance of various factors at the time of the first admission of the patient

Platz, H; Fries, R; Hudec, Marcus; Tjoa, A Min; Wagner, Roland

doi:10.1016/s0301-0503(83)80005-8

Cited by 89 publications

(39 citation statements)

References 36 publications

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“…2 This is despite current evidence suggesting that bone invasion is not an independent prognostic factor when confounding variables such as tumor size and involved surgical margins are taken into consideration. [4][5][6]9 However, the studies to date are generally limited by small sample sizes and failure to distinguish between cortical and medullary invasion, making it difficult to derive any definitive conclusions. The present study reconciles the difference between prior studies and expert opinion by demonstrating that only medullary bone invasion is an adverse prognostic feature after adjusting for potential confounding variables in a study with sufficient power.…”

Section: Discussionmentioning

confidence: 99%

“…This is in keeping with previous studies that classified bone invasion in this way and found no association with adverse outcomes. 4,6,8,9 The exception to this was a retrospective analysis by Jones et al of 82 patients with oral and oropharyngeal SCC undergoing mandibulectomy. 7 However, 31 (93.9%) of 33 patients with bone invasion had oral cancer in this study, compared with 17 (34.7%) of 49 patients without bone invasion, introducing primary site as a potential confounding factor.…”

Section: Discussionmentioning

confidence: 99%

“…Whereas some authors have reported an association with adverse outcomes on univariate analysis, [3][4][5][6][7] other studies did not support this finding. [8][9][10] Furthermore, multivariate analyses taking into account potential confounding factors such as tumor size and involved margins have suggested that bone invasion is not an independent predictor of survival.…”

mentioning

confidence: 86%

“…[8][9][10] Furthermore, multivariate analyses taking into account potential confounding factors such as tumor size and involved margins have suggested that bone invasion is not an independent predictor of survival. [4][5][6] Unfortunately, the majority of the studies to date were limited by small sample sizes and failed to distinguish between cortical and medullary bone invasion, making reliable conclusions difficult.…”

mentioning

confidence: 99%

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The prognostic and staging implications of bone invasion in oral squamous cell carcinoma

Ebrahimi

Murali

Gao

et al. 2011

Cancer

105

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BACKGROUND: A study was undertaken to determine whether bone invasion is an independent prognostic factor in oral squamous cell carcinoma (SCC) after taking into account the extent of bone invasion. METHODS: The study was a retrospective review of 498 patients with oral SCC undergoing surgery with curative intent, 102 of whom had pathologically proven bone invasion. Bone invasion was categorized as absent, cortical, or medullary and tested for association with disease control and survival. RESULTS: After adjusting for potential confounding factors in multivariate analysis, there was no association between cortical invasion and overall (P ¼ .48) or disease-specific survival (P ¼ .63). In contrast, medullary invasion was an independent predictor of reduced overall (hazard ratio [HR], 1.9; 95% confidence interval [CI], 1.2-3.1; P ¼ .006) and disease-specific survival (HR, 2.1; 95% CI, 1.2-3.6; P ¼ .01), and this appeared to result from an increased risk of distant metastatic failure (P ¼ .037) rather than local (P ¼ .51) or regional recurrence (P ¼ .14). Within the subset of patients with medullary invasion, survival differed significantly according to tumor size (P ¼ .029). CONCLUSIONS: Patients with oral SCC and bone invasion have widely variable outcomes depending on the depth of bone invasion and tumor size. The results suggest that the current American Joint Committee on Cancer staging system, which classifies all tumors invading through cortical bone as T4, has limited prognostic utility. The authors recommend a revision of the T staging system such that tumors are classified as T1 to T3 based on size and then upstaged by 1 T stage in the presence of medullary bone invasion. Cancer 2011;117:4460-7.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 86%

mentioning

confidence: 99%

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The prognostic and staging implications of bone invasion in oral squamous cell carcinoma

Ebrahimi

Murali

Gao

et al. 2011

Cancer

105

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“…It also affects the surgeon's ability to achieve complete resection, especially in deep invading tumours. Increased tumour size has been linked to cervical involvement [16,19], high recurrence rate [16,20], and poor prognosis [21,22].…”

Section: N3mentioning

confidence: 99%

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

Omar

2013

Journal of Oral Oncology

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Objective. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources. A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, prognostic factors of oral cancer, diagnostic method of oral cancer, and imaging techniques for diagnosis of oral cancer. The search was restricted to articles published in English, with no publication date restriction (last update April, 2013). Review Methods. In this paper, I approach the factors of prognosis of OSCC and the new advances in diagnostic technologies as well. I also reviewed available studies of the tissue fluorescence spectroscopy and other noninvasive diagnostic aids for OSCC. Results. The outcome is greatly influenced by the stage of the disease (especially TNM). Prognosis also depends or varies with tumour primary site, nodal involvement, tumour thickness, and the status of the surgical margins. Conclusion. Tumour diameter is not the most accurate when compared to tumour thickness or depth of invasion, which can be related directly to prognosis. There is a wide agreement on using ultrasound guided fine needle aspiration biopsies in the evaluation of lymph node metastasis.

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Microvascular Invasion and Survival in Cancer of the Oral Cavity and Oropharynx

Close¹,

Brown²,

Vuitch³

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\Although the presence of squamous cell carcinoma within the peritumoral vascular spaces of primary lesions of the oral cavity and oropharynx has been statistically linked to regional lymph node metastases, the association of this finding with disease control and survival has not been well demonstrated. To evaluate this relationship, we have reviewed the clinical and histopathologic features of 65 consecutive cases of previously untreated T2 or greater squamous cell carcinoma of these sites managed by simultaneous surgical treatment of the primary lesion and regional lymph nodes. Of all the histopathologic features of the primary lesion studied, vascular invasion had the greatest impact on survival, as confirmed by both univariate and multivariate analysis. In addition, vascular invasion correlated statistically with local recurrence, neck recurrence, and distant metastasis. TX 75235-9035 (Dr Close).

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The prognostic relevance of various factors at the time of the first admission of the patient

Cited by 89 publications

References 36 publications

The prognostic and staging implications of bone invasion in oral squamous cell carcinoma

The prognostic and staging implications of bone invasion in oral squamous cell carcinoma

The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

Microvascular Invasion and Survival in Cancer of the Oral Cavity and Oropharynx

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