The prognostic nutritional index predicts the biochemical recurrence of patients treated with robot‐assisted laparoscopic radical prostatectomy

Li, Nichujie; Song, Weijie; Gao, Jun; Xu, Zhipeng; Li, Zhi; Liu, Jianye; He, Leye

doi:10.1002/pros.24263

Cited by 7 publications

(6 citation statements)

References 31 publications

(32 reference statements)

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“…The total tumor recurrence rate and OS of patients in the higher PNI score group were higher than those in the lower PNI score group. The PNI index has been found to be an independent prognostic factor for a variety of malignant tumors, but none of these reports assessed the prognosis of PC [ 26 , 27 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy

Song

Gao

et al. 2022

Current Oncology

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Objective: To assess the value of using the prognostic nutritional index (PNI) and serum albumin/globulin ratio (AGR) in predicting the overall survival (OS) of patients with penile cancer (PC) undergoing penectomy. Materials and methods: A retrospective analysis of 123 patients who were admitted to our hospital due to PC from April 2010 to September 2021 and who underwent penectomy were included in the study. The optimal cut-off value of the PNI and AGR was determined by receiver operating characteristic curve analysis. Kaplan–Meier analysis and the Cox proportional hazard model were used to evaluate the correlation between the PNI, AGR, and OS in patients with PC. Results: A total of 16 of the 123 patients died during the follow-up period, and the median follow-up time was 58.0 months. The best cut-off values of the PNI and AGR were set to 49.03 (95% confidence interval 0.705–0.888, Youden index = 0.517, sensitivity = 57.9%, specificity = 93.7%, p < 0.001) and 1.28 (95% confidence interval 0.610–0.860, Youden index = 0.404, sensitivity = 84.1%, specificity = 56.2%, p = 0.003). The Kaplan–Meier analysis showed that the OS of the patients in the high PNI group and the high AGR group was significantly higher than that of the patients in the low PNI group and the low AGR group (p < 0.001). The univariable analysis showed that the aCCI, the clinical N stage, the pathological stage, and the PNI, AGR, SII, and PLR are all predictors of OS in patients with PC (p < 0.05). The multivariable analysis showed that the PNI (risk rate [HR] = 0.091; 95% CI: 0.010–0.853; p = 0.036) and the AGR (risk rate [HR] = 0.171; 95% CI: 0.043–0.680; p = 0.012) are independent prognostic factors for predicting OS in patients with PC undergoing penectomy. Conclusions: Both the PNI score and the serum AGR are independent prognostic factors for predicting OS in patients with PC undergoing penectomy.

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Section: Discussionmentioning

confidence: 99%

The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy

Song

Gao

et al. 2022

Current Oncology

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“…However, some prostate cancer patients treated with RARP are still unable to avoid BCR, so there is an urgent need to nd an easily accessible and low-cost biomarker to predict it. To our knowledge, previous studies have evaluated PNI as a predictor of prognosis in patients with RARP (15). In this study, we will further con rm their correlation.…”

Section: Introductionmentioning

confidence: 72%

Predictive model of pre-operative prognostic nutrition index for biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy: a retrospective clinical study

Zhao,

Qian,

et al. 2024

Preprint

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Objective: To investigate the predictive value of pre-operative prognostic nutritional index (PNI) in biochemical recurrence (BCR) in patients with robot-assistedlaparoscopic radical prostatectomy (RARP) and to establish a BCR risk score model based on PNI. Methods: The clinical data of 157 patients treated with RARP in the Department of Urology, the First Affiliated Hospital of Soochow University were retrospectively analyzed. The endpoint of observation was BCR. The area under the receiver operating characteristic (ROC) curve was evaluated to determine the optimal cutoff value for PNI. Kaplan-Meier analysis and Cox regression analysis were used to evaluate the correlation between PNI and BCR. 157 patients were divided into a training group and a validation group by a ratio of 7:3. By univariate and multivariate Cox regression analysis, independent prognostic factors were screened from the relevant clinicopathological factors, a BCR prediction model and nomogramwere established, then verified its value. Results: According to the ROC curve, the optimal cutoff value of PNI for 157 patients in this study was 47.425. According to multivariate Cox regression analysis, PNI and prostate-specific antigen (PSA) were identified as independent prognostic factors for predicting BCR in patients treated with RARP. A BCR prediction model formula was established based on PNI and PSA. It was proved to have good predictive value in both the training group and the validation group. Nomogram was constructed to predict the BCR of patients treated with RARP at 6-, 12-, and 24-months after surgery. The results of the calibration plots showed that the nomogram performed well in the training group and the validation group. Conclusion: PNI is an independent prognostic factor for predicting BCR in patients treated with RARP. The scoring model and nomogram based on PNI and PSA can effectively predict the risk of BCR in patients treated with RARP.

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Section: Discussionmentioning

confidence: 99%

The predictive significance of prognostic nutritional index and serum albumin/globulin ratio on the overall survival of penile cancer patients undergoing penectomy

Song

Gao

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Objective: To assess the value of using the prognostic nutritional index (PNI) and serum albumin/globulin ratio (AGR) in predicting the overall survival (OS) of patients with penile cancer (PC) undergoing penectomy. Materials and methods: A retrospective analysis of 123 patients who were admitted to our hospital due to PC from April 2010 to September 2021 and underwent penectomy were included in the study. The optimal cut-off value of PNI and AGR was determined by receiver operating characteristic curve analysis. Kaplan-Meier analysis and the Cox proportional hazard model were used to evaluate the correlation between PNI, AGR, and OS in patients with PC. Results: The best cut-off values of PNI and AGR were set to 49.03 (95% confidence interval 0.705-0.888, Youden index=0.517, sensitivity=57.9%, specificity=93.7%, P<0.001) and 1.28 (95% confidence interval 0.610-0.860, Youden index=0.404, sensitivity=84.1%, specificity=56.2%, P=0.003). Kaplan-Meier analysis showed that the OS of the patients in the high PNI group and the high AGR group was significantly higher than that of the patients in the low PNI group and the low AGR group (P<0.001). Univariate analysis showed that patient age, clinical N stage, pathological stage, PNI, and SII are all predictors of OS in patients with PC (P<0.05). Multivariate analysis showed that pathological stage (P=0.005), PNI (P=0.021), and AGR (P=0.004) are independent prognostic factors for predicting OS in patients with PC undergoing penectomy. Conclusions: Both PNI score and serum AGR are independent prognostic factors for predicting OS in patients with PC undergoing penectomy.

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The prognostic nutritional index predicts the biochemical recurrence of patients treated with robot‐assisted laparoscopic radical prostatectomy

Cited by 7 publications

References 31 publications

The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy

The Predictive Significance of Prognostic Nutritional Index and Serum Albumin/Globulin Ratio on the Overall Survival of Penile Cancer Patients Undergoing Penectomy

Predictive model of pre-operative prognostic nutrition index for biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy: a retrospective clinical study

The predictive significance of prognostic nutritional index and serum albumin/globulin ratio on the overall survival of penile cancer patients undergoing penectomy

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