The Prognostic Influence of Chronicity of Rhegmatogenous Retinal Detachment on Anatomic Success After Reattachment Surgery

James, Mark A.; O'Doherty, M; Beatty, Stephen

doi:10.1016/j.ajo.2007.01.057

Cited by 16 publications

(17 citation statements)

References 6 publications

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“…We excluded patients with a history of trauma or proliferative vitreo-retinopathy exceeding grade 3, and those eyes with a chronic retinal detachment. The latter was defined by a history of visual loss lasting 3 months in the presence of a detached retina with signs of chronicity, such as pigmented demarcation line, intraretinal cyst, and/or retinal thinning [12]. We also excluded eyes with prior history of RRD, as well as eyes with a giant retinal tear.…”

Section: Methodsmentioning

confidence: 99%

Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for acute rhegmatogenous retinal detachment

Ehrlich

Ahmad

Welch

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Section: Methodsmentioning

confidence: 99%

Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for acute rhegmatogenous retinal detachment

Ehrlich

Ahmad

Welch

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…Eyes with longer RD duration, proliferative vitreoretinopathy (PVR) of any type, and severe PVR have worse initial and final visual acuities than eyes with shorter RD duration or those without PVR respectively [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Preoperative duration of retinal detachment and preoperative central retinal artery hemodynamics: repercussion on visual acuity

Roldán-Pallarés

Musa

Hernandez-Montero

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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Preoperative CRA parameters and LogMAR VAs (pre-, and postoperative 8 months) were influenced by preoperative RD duration in both no PVR and PVR. Preoperative CRA parameters were correlated with LogMAR VAs (pre-, postoperative 8 months, and the difference) only in PVR. Postoperative 8 months and preoperative LogMAR VAs were only correlated (with statistical significance) in macula-on cases of both the PVR and no PVR groups.

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“…It is estimated that PVR occurs as a complication in up to 5–20% of cases of rhegmatogenous retinal detachment (Al-Khairi et al, 2008; Asaria and Gregor, 2002; Campochiaro, 1997; Cardillo et al, 1997; Charteris et al, 2002; Glaser et al, 1987; Hinton et al, 2002; James et al, 2007; Kirchhof, 2004; Kruger et al, 2002). In ocular trauma, the risk of PVR is very high.…”

Section: Introductionmentioning

confidence: 99%

Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells

Morales

Telander²,

Mareninov

et al. 2012

Experimental Eye Research

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Epithelial membrane protein 2 (EMP2) regulates collagen gel contraction by the retinal pigment epithelium cell line ARPE-19 by modulating FAK activation. Collagen gel contraction is one in vitro model for an aberrant wound healing response, proliferative vitreoretinopathy (PVR), which occurs as a complication of severe ocular trauma. The purpose of this study is to investigate whether EMP2 specific recombinant diabody decreases activation of FAK and collagen gel contraction in ARPE-19. Anti-EMP2 diabody was recombinantly constructed from a human phage library-derived clone selected for reactivity against an extracellular domain of human EMP2. ARPE-19 cells were exposed to an anti-EMP2 or control diabody, and toxicity, adhesion, and migration were assessed respectively through toluidine blue exclusion, binding to collagen type 1, and a migration assay. Collagen gel contraction was assessed using an in vitro assay. FAK activation was evaluated using Western blot. Exposure to anti-EMP2 diabody resulted in a 75% reduction in EMP2 protein levels at 4 hours. No significant toxicity was observed with anti-EMP2 diabody at levels that maximally reduced EMP2. Anti-EMP2 diabody, but not control diabody significantly reduced collagen gel contraction (p<0.001), and was not secondary to changes in adhesion or migration. Concordantly, anti-EMP2 diabody as compared to a control diabody reduced collagen stimulated FAK activation (p=0.01). Anti-EMP2 diabody decreases EMP2 protein levels, FAK activation, and collagen gel contraction by ARPE-19 cells without an adverse effect on cell survival. Modulation of EMP2 using anti-EMP2 diabody could be a new approach for targeting EMP2 and pathologic consequences associated with EMP2.

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The Prognostic Influence of Chronicity of Rhegmatogenous Retinal Detachment on Anatomic Success After Reattachment Surgery

Cited by 16 publications

References 6 publications

Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for acute rhegmatogenous retinal detachment

Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for acute rhegmatogenous retinal detachment

Preoperative duration of retinal detachment and preoperative central retinal artery hemodynamics: repercussion on visual acuity

Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells

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