The prognostic impact of serum bilirubin in stage IV colorectal cancer patients

Yang, Lin; Ge, Lu-Yao; Takata, Yasuyuki; Liang, Yan; Yin, Ying; Chen, Hong

doi:10.1002/jcla.22272

Cited by 16 publications

(12 citation statements)

References 19 publications

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“…In the right-sided colon group, the time-dependent ROC curve of the albumin-NLR was superior to the mGPS and SIS starting at the 16th month after surgery, and the AUC of the albumin-NLR for OS ranged from 0.579 to 0.669 since then. Although the AUC of the albumin-NLR in our study was less than 0.7, it was in accordance with the AUC of the classic prognostic factors reported for CRC patients, such as CEA [ 26 , 27 ].…”

Section: Discussionsupporting

confidence: 91%

Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer

Wang

Jiang

et al. 2018

BMC Cancer

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BackgroundThe modified Glasgow Prognostic Score (mGPS) and the neutrophil-to-lymphocyte ratio (NLR) are conventional inflammation-based scores for colorectal cancer (CRC). The systemic inflammation score (SIS) has been shown to be more informative than the mGPS in CRC. The albumin-NLR, composed of albumin and the NLR, can also be a candidate for a valuable inflammation score. However, about the utility of the mGPS, SIS, and albumin-NLR for CRC patients who have received radical resections remains unclear.MethodsThis study enrolled 877 CRC patients, who underwent radical surgical resection between January 1, 2007 and December 31, 2014. The prognostic values of the mGPS, SIS, and albumin-NLR were compared by the Kaplan-Meier survival analysis, multivariate Cox regression modelling, and the time-dependent receiver operating characteristic curve analysis (ROC).ResultsIn the Kaplan-Meier analysis, all three inflammation scores were significantly associated with overall survival (OS) in the group including all the patients (mGPS, p = 0.016; SIS, p < 0.001; albumin-NLR, p = 0.007) and in the left-sided colon tumour subgroup (mGPS, p = 0.029; SIS p = 0.0013; albumin-NLR, p = 0.001). In the right-sided colon tumour subgroup, only the albumin-NLR was associated with OS (p = 0.048). The albumin-NLR was the only independent prognostic factor of the three scores for OS in the multivariate survival analysis.ConclusionsThe albumin-NLR outperformed both the SIS and mGPS in predicting OS in CRC patients undergoing radical resection.

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Section: Discussionsupporting

confidence: 91%

Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer

Wang

Jiang

et al. 2018

BMC Cancer

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“…Zhang et al found that high DBIL level was an independent prognostic factor for OS and DFS, and a higher proportion of lymph node metastasis and lymphovascular invasion was observed at higher DBIL levels than at lower DBIL levels [10]. Yang et al also found that in stage IV CRC patients, elevated levels of TBIL and DBIL were associated with poor OS [20]. DBIL can be considered an independent prognostic biomarker of OS, and the prognostic effect of DBIL on OS is similar to that of carcinoembryonic antigen (CEA).…”

Section: Discussionmentioning

confidence: 99%

A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients

et al. 2021

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Background Serum bilirubin and total bile acid (TBA) levels have been reported to be strongly associated with the risk and prognosis of certain cancers. Here, we aimed to investigate the effects of pretreatment levels of serum bilirubin and bile acids on the prognosis of patients with colorectal cancer (CRC). Methods A retrospective cohort of 1474 patients with CRC who underwent surgical resection between January 2015 and December 2017 was included in the study. Survival analysis was used to evaluate the predictive value of pretreatment levels of bilirubin and bile acids. X-Tile software was used to identify optimal cut-off values for total bilirubin (TBIL), direct bilirubin (DBIL) and TBA in terms of overall survival (OS) and disease-free survival (DFS). Results DBIL, TBIL, and TBA were validated as significant prognostic factors by univariate Cox regression analysis for both 3-year OS and DFS. Multivariate Cox regression analyses confirmed that high DBIL, TBIL and TBA levels were independent prognostic factors for both OS (HR: 0.435, 95% CI: 0.299–0.637, P < 0.001; HR: 0.436, 95% CI: 0.329–0.578, P < 0.001; HR: 0.206, 95% CI: 0.124–0.341, P < 0.001, respectively) and DFS (HR: 0.583, 95% CI: 0.391–0.871, P = 0.008; HR:0.437,95% CI: 0.292–0.655, P <0.001; HR: 0.634, 95% CI: 0.465–0.865, P = 0.004, respectively). In addition, nomograms for OS and DFS were established according to all significant factors, and the c-indexes were 0.819 (95% CI: 0.806–0.832) and 0.835 (95% CI: 0.822–0.849), respectively. Conclusions TBIL, DBIL and TBA levels are independent prognostic factors in colorectal cancer patients. The nomograms based on OS and DFS can be used as a practical model for evaluating the prognosis of CRC patients.

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“…Bilirubin has been reported to possess important antioxidant and anticancer functions and was considered as an efficient prognostic biomarker for overall survival in advanced CRC [ 23 , 24 ]. Lower plasma bilirubin levels were found in CRC compared to healthy controls [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas

et al. 2021

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Sporadic colorectal cancer is characterized by a multistep progression from normal epithelium to precancerous low-risk and high-risk adenomas to invasive cancer. Yet, the underlying molecular mechanisms of colorectal carcinogenesis are not completely understood. Within the “Metabolomic profiles throughout the continuum of colorectal cancer” (MetaboCCC) consortium we analyzed data generated by untargeted, mass spectrometry-based metabolomics using plasma from 88 colorectal cancer patients, 200 patients with high-risk adenomas and 200 patients with low-risk adenomas recruited within the “Colorectal Cancer Study of Austria” (CORSA). Univariate logistic regression models comparing colorectal cancer to adenomas resulted in 442 statistically significant molecular features. Metabolites discriminating colorectal cancer patients from those with adenomas in our dataset included acylcarnitines, caffeine, amino acids, glycerophospholipids, fatty acids, bilirubin, bile acids and bacterial metabolites of tryptophan. The data obtained discovers metabolite profiles reflecting metabolic differences between colorectal cancer and colorectal adenomas and delineates a potentially underlying biological interpretation.

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The prognostic impact of serum bilirubin in stage IV colorectal cancer patients

Abstract: Pre-treatment elevated TBIL and DBIL levels were associated with poor OS in stage IV CRC patients. Moreover, DBIL could be considered as an independent prognostic biomarker for OS. Furthermore, DBIL had similar prognostic efficacy as CEA for OS.

Cited by 16 publications

References 19 publications

Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer

Prognostic value of inflammation-based scores in patients receiving radical resection for colorectal cancer

A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas

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