The prognostic effect of metastasis patterns on overall survival in organ metastatic lung adenocarcinoma

Abstract

The effect of various metastases patterns on the prognosis of lung adenocarcinoma (AD) remains unknown. The purpose of our retrospective study is to determine whether various metastases patterns have a prognostic impact on patients with organ metastatic lung AD. Patient data was extracted from the Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan–Meier method was chosen for the evaluation of overall survival (OS) rate. Univariable and multivariable Cox regression analyses were conducted to evaluate independent prognostic factors. In the SEER database, 12,228 patients with IV lung AD were retrieved in total. And 78.78% of those patients (9633/12,228) suffered from one of brain, lung, liver or bone metastasis due to disease progression. It was found that the most common site in patients with metastatic lung AD was brain (21.20%), and the least common site of metastasis was liver (3.50%). Patients who suffered single lung metastatic showed relatively good OS, and the median survival time was 11 months (95% CI 0.470–0.516). For those with 2 metastatic sites, data analysis suggested that the median survival times of patients with bone and lung metastasis (10 months; 95% CI 0.469–0.542) were better than others. For those with 3 metastatic sites, data analysis suggested that metastatic pattern had no effect on the OS. Brain is the most common single metastasis site of lung AD. Compared with the other 3 metastatic sites, patients with lung metastasis had better survival results. Deeper knowledge of metastatic patterns will help doctors to better understand the prognosis and formulate more appropriate treatment plans.

Distant organ metastasis patterns and prognosis of lung adenosquamous carcinoma: a SEER database analysis

“…Our research found that the bone is the most common site of organ metastasis in ASC. Similarly, previous articles have shown that bone and brain (25–40%) are the most common sites of metastasis in NSCLC [ 7 , 8 ]. We investigated the impact of metastatic patterns on the survival of ASC.…”

Prognostic impact of metastatic patterns and treatment modalities on overall survival in lung squamous cell carcinoma: A population-based study

“…Notably, patients with lung metastasis exhibited the longest OS, and multivariate Cox analysis further corroborated these findings, demonstrating that patients with lung metastasis had a more favorable prognosis, which aligns with previous research. [18] However, despite the relatively better prognosis associated with lung metastasis compared to metastasis to other organs, we recommend regular monitoring of suspicious lung nodules to mitigate the risk of death due to the high incidence of lung metastasis. Patients with bone metastasis had the worst OS, and Cetin et al [19] study found that bone metastasis is a significant risk factor that affects the prognosis of LUSC patients, significantly impacting their quality of life, increasing their risk of death, and leading to at least 1 skeletal-related event per year.…”