The prognostic and predictive significance of serum thiols and disulfide levels in advanced non-small cell lung cancer

Karataş, Fatih; Acat, Murat; Şahin, Süleyman; İnci, Fatih; Karataş, Gülşah; Neşeli̇oğlu, Salim; Haskul, Ismail; Erel, Özcan

doi:10.1080/13685538.2018.1559805

Cited by 12 publications

(13 citation statements)

References 33 publications

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“…The thiol/disulfide system, which is one of the most important antioxidant systems of the human body, can be oxidized in the presence of free oxygen radicals due to the thiol groups and can be reversibly converted to the sulfhydryl bonds ( 29 ) . TDH has been investigated for many physiological conditions such as apoptosis, antioxidant defense mechanisms as well as for pathological processes such as cancer, diabetes mellitus, intrauterine growth restriction, obstructive sleep apnea, and so on ( 13 , 14 , 30 , 31 , 32 , 33 ) . Hydrogen sulfide (H 2 S), a functional group of native thiol, regulates the vascular tone through nitric oxide ( 34 ) .…”

Section: Discussionmentioning

confidence: 99%

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

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Objective: Preeclampsia (PE) is a dangerous complication of pregnancy and still a major cause of maternal-fetal morbidity and mortality. Its etiology remains largely unknown, but researchers have suggested oxidative stress-mediated inflammation for the same. The purpose of this study is to investigate the relationship between oxidative stress and PE as well as the usability of oxidative stress indicators such as serum ischemia-modified albumin (IMA) levels and thiol/disulfide balance in the prediction of PE. Materials and Methods: The study included 47 pregnant women with PE and 57 healthy pregnant women. We measured their serum IMA, native thiol, total thiol, and disulfide levels. Additionally, we determined the optimal cutoff values via the receiver operating characteristic curve analysis. Results: There were no differences between the two groups with respect to the maternal age, body mass index, gravida, and parity. The native and total thiol levels were found to be low when the disulfide and IMA levels were high in the patients with PE (p<0.05). When the IMA level was corrected by the albumin level (IMAR), the significant difference between the two groups disappeared. We also found that the native and total thiol concentrations were correlated with the systolic and diastolic blood pressures. The optimal cut-off values calculated for the prediction of PE were as follows: 178.45 µmol/L (with sensitivity of 72% and specificity of 83%) for native thiol, 232.55 µ mol/L (with a sensitivity of 75% and specificity of 85%) for total thiol, and 29.05 µmol/L (with sensitivity of 65% and specificity of 72%) for disulfide. Conclusion: The balance of thiol/disulfide may play a role in the pathogenesis of PE and could be used as a biological marker for PE.

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Section: Discussionmentioning

confidence: 99%

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Onat¹,

Kırmızı²,

Başer³

et al. 2020

tjod

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“…Three studies described the thiol redox status in patients affected by lung cancer (Table 1). All of these studies found total thiol levels, and two studies found native thiol levels and disulfide levels to be reduced in lung cancer patients compared to healthy controls [5,19,20]. These results indicate that the extracellular antioxidant capacity is generally compromised in these patients.…”

Section: Lung Cancermentioning

confidence: 94%

“…These results indicate that the extracellular antioxidant capacity is generally compromised in these patients. In addition, one study described that total thiol levels were associated with ageing and a history of smoking [19], whereas another study described that current smoking, COPD, the histological subtypes of the tumor or arterial hypertension were not associated with thiol/disulfide homeostasis in this patient group [20], although this might be the result of a lack of statistical power. Patients with lower total thiol levels showed a significantly lower Karnofsky performance score [5].…”

Section: Lung Cancermentioning

confidence: 99%

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Systemic oxidative stress and antioxidant capacity in cancer patients

Leimkühler¹,

Bourgonje²,

Goor

et al. 2020

J Transl Sci

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“…Thiols form covalent disulphide bonds with oxidants during tissue oxidation. These disulphide bonds can be reduced back to the thiols, resulting in the formation of a dynamic thiol/disulphide homeostasis, which plays a very important role in antioxidation, and, therefore, it is believed to play a role in the pathogenesis of numerous diseases such as diabetes, coronary artery disease, and cancer [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Prostat Kanseri Tanısında Thiol/Disülfid Dengesi PSA'ya Ek Bir Serum Belirteç Olarak Güvenilir midir?

et al. 2019

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Amaç: Bu çalışmada, prostat kanseri tanısında thiol/disülfid dengesinin prostat spesifik antijene (PSA) ek bir serum markırı olarak değerlendirmeyi amaçladık. Hastalar ve Yöntemler: Prospektif çalışmamız PSA düzeyi 2.5-20 ng / mL olan, rektal muayenede malignite şüphesi olmayan ve prostat iğnesi biyopsisi yapılan toplam 174 hasta üzerinde yapıldı. Dışlama kriterleri sonrası çalışmamıza toplam 75 hasta dahil edildi. Biyopsi öncesi hastaların serum PSA, thiol ve disülfid düzeyleri kaydedildi. Çalışmamıza patoloji sonucu prostat kanseri olan 25 hasta, patoloji sonucu kronik prostatit olan 25 hasta ve patoloji sonucu benign prostat hiperplazisi (BPH) olan 25 hasta dahil edildi. Bulgular: Prostat kanseri grubunda total ve native thiol seviyeleri BPH ve kronik prostatit gruplarından daha yüksekti; ancak, istatistiksel anlamlı bir farklılık gözlenmedi (p> 0.05). Prostat kanseri alt grupları incelendiğinde, total ve native thiol seviyelerinin Gleason skoru 7, 8 ve 9 olan hastalarda, Gleason skoru 6 olanlara göre daha yüksek olduğu saptandı; ancak, istatistiksel anlamlı bir fark gözlenmedi (p> 0.05). Sonuç: Thiol seviyeleri prostat kanseri grubunda, benign hastalık (BPH ve kronik prostatit) gruplarından daha yüksekti; bu seviyeler aynı zamanda Gleason skoru yüksek olan grupta (Gleason 7, 8 veya 9), Gleason skoru düşük olan (Gleason 6) gruba göre daha yüksekti; ancak, bu farklılıklar istatistiksel olarak anlamlı değildi.

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The prognostic and predictive significance of serum thiols and disulfide levels in advanced non-small cell lung cancer

Cited by 12 publications

References 33 publications

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

The relationship between oxidative stress and preeclampsia. The serum ischemia-modified albumin levels and thiol/disulfide homeostasis

Systemic oxidative stress and antioxidant capacity in cancer patients

Prostat Kanseri Tanısında Thiol/Disülfid Dengesi PSA'ya Ek Bir Serum Belirteç Olarak Güvenilir midir?

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