The prognosis of patients with small cell carcinoma of the cervix: a retrospective study of the SEER database and a Chinese multicentre registry

Chu, Tian; Meng, Yifan; Wu, Ping; Zheng, Le; Wen, Hao; Ren, Fang; Zou, Dongling; Lu, Huaiwu; Wu, Lingying; Zhou, Shengtao; Chen, Ying; Li, Jundong; Xu, Miaochun; Wu, Xinghan; Xiong, Xi; Wang, Zhibin; He, Misi; Zhang, Y; Lin, Shitong; Cao, Canhui; Ding, Wencheng; Chen, Yu; Zhi, Wenhua; Peng, Ting; Ye, Wei; Liu, Binghan; Xu, Yashi; Ma, Ding; Wang, Jing; Sun, Chaoyang; Wu, Peng

doi:10.1016/s1470-2045(23)00185-7

Cited by 14 publications

(6 citation statements)

References 27 publications

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“…In our survey, only 53% of respondents used the recommended chemoradiotherapy-based approach, while 34% used a surgical approach. Indeed, retrospective studies have shown conflicting evidence when comparing radiotherapy-based and surgical approaches in both early and locally advanced SCNECC [15][16][17][18], and prospective evidence is needed to determine the optimal definitive treatment modality. When prescribing concurrent chemoradiation, respondents in our survey most often prescribed concurrent EP, followed by 4-6 cycles of additional EP.…”

Section: Discussionmentioning

confidence: 99%

Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey

Fan,

Chehade,

Wang

et al. 2024

Current Oncology

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Small-cell neuroendocrine carcinoma of the cervix (SCNECC) is a rare cancer with poor prognosis, with limited data to guide its treatment. The objective of this study was to evaluate practice patterns in the management of SCNECC. A 23-question online survey on management of SCNECC was disseminated to Canadian gynecologic oncologists (GO), radiation oncologists (RO) and medical oncologists (MO). In total, 34 practitioners from eight provinces responded, including 17 GO, 13 RO and four MO. During staging and diagnosis, 74% of respondents used a trimodality imaging approach, and 85% tested for neuroendocrine markers. In early-stage (1A1-1B2) SCNECC, 87% of practitioners used a surgical-based approach with various adjuvant and neoadjuvant treatments. In locally advanced (1B3-IVA) SCNECC, 53% favored primary chemoradiation, with cisplatin and etoposide, with the remainder using surgical or radiation-based approaches. In metastatic and recurrent SCNECC, the most common first-line regimen was etoposide and platinum, and 63% of practitioners considered clinical trials in the first line setting or beyond. This survey highlights diverse practice patterns in the treatment of SCNECC. Interdisciplinary input is crucial to individualizing multimodality treatment, and there is a need for prospective trials and intergroup collaboration to define the optimal approach towards managing this rare cancer type.

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Section: Discussionmentioning

confidence: 99%

Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey

Fan,

Chehade,

Wang

et al. 2024

Current Oncology

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“…Both the SGO and the Gynecologic Cancer Intergroup (GCIG) recommend radical hysterectomy and pelvic lymphadenectomy followed by adjuvant chemotherapy with platinum + etoposide for early-stage disease (tumors ≤ 4 cm) and negative nodes on imaging (up to FIGO stage IIA1, approximately 50% of cases [78]), with consideration for additional radiotherapy, as women who received multimodality treatment can achieve long-term survival [79]. The role of surgery in early-stage NECs of the cervix has been strengthened by the results of a recent study, which included data of 1288 patients collected from the SEER database and from a Chinese multi-institutional registry [80]. Taking into consideration the limitations and biases of surgical studies conducted on retrospective series, surgery might improve the outcomes of patients with locally advanced or stage IB3-IIA2 NECs of the cervix, although in these cases surgery is not currently routinely recommended by guidelines.…”

Section: Necs Of the Cervixmentioning

confidence: 99%

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Stumpo,

Formelli,

Persano

et al. 2023

JCM

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Neuroendocrine carcinomas (NECs) are poorly differentiated and highly aggressive epithelial neuroendocrine neoplasms. The most common primary site is the lung, but they may arise in every organ. Approximately 37% of extrapulmonary NECs (EP-NECs) occur in the gastroenteropancreatic (GEP) tract, followed by the genitourinary (GU) system and gynecological tract. As a result of their rarity, there is scant evidence to guide treatment recommendations, and a multidisciplinary approach is essential for the management of such patients. Platinum-based chemotherapy currently represents the standard of care for EP-NECs of any site, mirroring the management of small-cell lung cancer (SCLC), but further approaches are still under investigation. Indeed, ongoing trials evaluating targeted therapies, immune checkpoint inhibitors (ICIs), and radionuclide therapy could provide potentially breakthrough therapeutic options. Given the relative dearth of evidence-based literature on these orphan diseases, the aim of this review is to provide an overview of the pathology and current treatment options, as well as to shed light on the most pressing unmet needs in the field.

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“…Surveillance, Epidemiology, and End Results (SEER) is representative of the US population, with patient-level data abstracted from diverse populations that represent rural, urban, and regional populations. With the help of the SEER database, assessing clinical issue on a larger sample with long follow-up, which can effectively avoid biases, many prognosis-related factors have been explored deeply in recent years [ 13 , 14 ]. Besides, as a convenient tool to predict and quantify the probability of an individual patient developing a certain clinical event, nomogram is helpful in clinical decision making, risk stratification, personalized treatment and clinical trial design.…”

Section: Introductionmentioning

confidence: 99%

Survival analysis and clinicopathological features of patients with stage IA lung adenocarcinoma

Li,

Wang,

Liu

et al. 2024

Heliyon

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The prognosis of patients with small cell carcinoma of the cervix: a retrospective study of the SEER database and a Chinese multicentre registry

Cited by 14 publications

References 27 publications

Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey

Pan-Canadian Analysis of Practice Patterns in Small Cell Carcinoma of the Cervix: Insights from a Multidisciplinary Survey

Extrapulmonary Neuroendocrine Carcinomas: Current Management and Future Perspectives

Survival analysis and clinicopathological features of patients with stage IA lung adenocarcinoma

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