The prognosis of contact dermatitis

Hogan, Daniel J.; Dannaker, Christopher J.; Maibach, Howard I.

doi:10.1016/0190-9622(90)70213-2

Cited by 108 publications

(59 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma samples for OPN enzymelinked immunosorbent assay (ELISA) were obtained from patients with long-lasting severe chronic ACD of the hands and/or feet or healthy controls without history of eczema. Blood samples for T cell activation assays were obtained from volunteers with sensitization against NiSO 4 , verified by positive patch test or nickel patch test negative donors as controls.…”

Section: Tissue Donorsmentioning

confidence: 99%

Antigen-Specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis

Seier¹,

Renkl²,

Schulz³

et al. 2010

The American Journal of Pathology

View full text Add to dashboard Cite

Allergic contact dermatitis is a T cell-mediated immune response , which in its relapsing chronic form is of high socioeconomic impact. The phosphoglycoprotein osteopontin (OPN) has chemotactic and Th1 cytokine functions and in various models is essential for robust T cell-mediated immunity. Here we demonstrate that OPN is abundantly expressed by both effector T cells and keratinocytes in allergic contact dermatitis lesions. T cells from nickel-allergic donors secrete high levels of OPN following antigen-specific stimulation. OPN may substitute for missing IFN-␥ secretion in T effector cells because low IFN-␥-producing T cell clones secrete high levels of OPN , and OPN down-modulates their interleukin-4 expression. Furthermore , interferon-␥ from T effector cells augments OPN in allergic contact dermatitis by inducing OPN in keratinocytes , which in turn polarizes dendritic cells and attracts inflammatory cells. In the murine contact hypersensitivity (CHS) model for allergic contact dermatitis , OPN is strongly induced in antigen-specific proliferating T cells , and OPN null mice display a reduced chronic CHS inflammatory response due to a decreased influx of effector T cells. Importantly, because of its function for chronic allergic contact dermatitis , OPN may well be a therapeutic target , because anti-OPN antibody treatment in part suppresses established chronic CHS.

show abstract

Section: Tissue Donorsmentioning

confidence: 99%

Antigen-Specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis

Seier¹,

Renkl²,

Schulz³

et al. 2010

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Hand eczema is the major occupational skin disease (8). It can cause great disability and has economic repercussions as it leads to chronic disease with long sick leave, change of job, and, in some cases, permanent disability pension (4,(9)(10)(11). The disease also affects health-related quality of life (12,13).…”

mentioning

confidence: 99%

Influence of childhood atopic dermatitis on future worklife

Nyrén¹,

Lindberg²,

Stenberg³

et al. 2005

Scand J Work Environ Health

View full text Add to dashboard Cite

“…In this study, there should have been a low percentage of occupational changes on the basis of two reasons. The subjects followed in the study were young while in other studies the high percentage of occupational changes was found in persons above 40 years old [15,16], and the main causes for CD were mixtures of organic solvents, which usually has a good prognosis [17,18]. The only MC which had a relatively low percentage of occupational changes was the air force (30.2%), while in the logistic units the occupational changes were higher than expected (52.1%).…”

Section: Discussionmentioning

confidence: 99%

“…Deliberate exposure of the skin to an irritant or allergen known to the patient is a potential but rare cause of persistence of occupational CD [3,12]. Usually a worker's compensation is lower than a worker's normal wage in most areas [3,12,15,16]. This research examined occupational changes in a population, which gains advantage out of the occupational change, since after a change in occupation they are usually employed in easier jobs.…”

Section: Discussionmentioning

confidence: 99%

Contact Dermatitis – Relation between Job Assignment and Work Motivation in a Young Israeli Adult Population

et al. 2002

View full text Add to dashboard Cite

Background: In this study, we evaluated the role of motivation and other parameters on job assignment in young Israeli soldiers who changed their occupation after the diagnosis of contact dermatitis (CD). Objective: To evaluate the influence of motivation and other parameters on job assignment in young Israeli soldiers with CD. Methods: The files of 336 soldiers who were diagnosed as having CD after their conscription to military service during the years 1986–1989 in the Israel Force were investigated. We compared the rate of occupational changes in the different commands and evaluated different discipline parameters between soldiers who did or did not change their job due to CD. Results: The percentage of job assignment (42.3%) in the study population was higher than the expected rate. A difference was detected in the rate of occupational changes following the diagnosis of CD among different military commands. The frequency of discipline parameters was higher among soldiers who changed job assignment following the diagnosis of CD (n = 142) and soldiers who did not (n = 194). Conclusion: The occupational changes in the various military commands and the differences in the discipline parameters imply that motivation is an important determinant affecting changes in job assignment following the diagnosis of CD.

show abstract

The prognosis of contact dermatitis

Cited by 108 publications

References 44 publications

Antigen-Specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis

Antigen-Specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis

Influence of childhood atopic dermatitis on future worklife

Contact Dermatitis – Relation between Job Assignment and Work Motivation in a Young Israeli Adult Population

Contact Info

Product

Resources

About