The prognosis of a normal Tl-201 stress-only SPECT MPI study

Duvall, W. Lane; Hiensch, Robert; Levine, Elliot J.; Croft, Lori B.; Henzlova, Milena J.

doi:10.1007/s12350-012-9601-2

Cited by 18 publications

(9 citation statements)

References 22 publications

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“…35 Numerous studies have demonstrated the value of a normal exercise MPI with a low annual cardiac event rate (\1%) for most patients. 6,31,33,34,36 Even in patients with known CAD, the primary event rate with normal exercise MPI or echocardiography is relatively low. 29,31,32,37 -41 In our study, the CV mortality in the normal MPI group was 0% and the CV mortality plus MI were 1.1%/year after about 4 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

Outcome of patients with high-risk Duke treadmill score and normal myocardial perfusion imaging on spect

Vítola¹,

Wanderley

Cerci³

et al. 2016

Journal of Nuclear Cardiology

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Section: Discussionmentioning

confidence: 99%

Outcome of patients with high-risk Duke treadmill score and normal myocardial perfusion imaging on spect

Vítola¹,

Wanderley

Cerci³

et al. 2016

Journal of Nuclear Cardiology

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“…Nessa situação, estudos recentes demonstraram que o valor prognóstico da prova fica mantido, a capacidade diagnóstica semelhante às custas de elevada sensibilidade, bem como o paciente recebe menor dose de atividade radioativa e tem o tempo total de exame diminuído. 32,33 5.3. Cintilografia de Perfusão Miocárdica com Imagens Tomográficas Sincronizadas pelo Eletrocardiograma (Gated-SPECT) [34][35][36][37][38][39][40][41] As imagens cardíacas devem ser adquiridas de maneira sincronizada com o ECG do paciente, permitindo a análise adicional da função ventricular e de forma simultânea a avaliação da perfusão miocárdica.…”

Section: Cintilografia De Perfusão Miocárdica Com Imagens Tomográficaunclassified

Atualização da Diretriz Brasileira de Cardiologia Nuclear – 2020

Mastrocola

Amorim

Vítola³

et al. 2020

ABC Cardiol

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“…The new‐generation dedicated cardiac systems enable “stress‐first” SPECT protocols with lower doses and obviate the need for subsequent rest studies if stress studies are normal (~60% of cases) . This has been shown to reduce radiation exposures to patients and associated personnel, but acquisitions take about 10–14 min . Additionally, these new cameras are not yet prevalent, with standard Anger camera‐based systems still used for the vast majority of patients.…”

Section: Introductionmentioning

confidence: 99%

Performance analysis of a high‐sensitivity multi‐pinhole cardiac SPECT system with hemi‐ellipsoid detectors

Bhusal

Dey

et al. 2018

Medical Physics

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Purpose: Single-photon emission computed tomography (SPECT) is a noninvasive imaging modality, used in myocardial perfusion imaging. The challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. This improvement can be used to decrease acquisition time and/or dose. However, in the case of ultra-low dose (~3 mCi) injections, acquisition times are still significantly long, taking 10-12 min. The purpose of this work is to investigate a new gamma camera design with 21 hemiellipsoid detectors each with a pinhole collimator for cardiac SPECT for further improvement in sensitivity and resolution and reduced patient exposures and imaging times. Methods: To evaluate the resolution of our hemi-ellipsoid system, GATE Monte-Carlo simulations were performed on point-sources, rod-sources, and NCAT phantoms. For average full-width-half-maximum (FWHM) equivalence with base flat-detector, the pinhole-diameter for the curved hemi-ellipsoid detector was found to be 8.68 mm, an operating pinhole-diameter nominally expected to be~3 times more sensitive than state-of-the-art systems. Rod-sources equally spaced within the region of interest were acquired with a 21-detector system and reconstructed with our multi-pinhole (MPH) iterative OSEM algorithm with collimator resolution recovery. The results were compared with the results of a state-of-the-art system (GE Discovery) available in the literature. The system was also evaluated using the mathematical anthropomorphic NCAT (NURBS-based Cardiac Torso; Segars et al. IEEE Trans Nucl Sci. 1999;46:503-506) phantom with a full (clinical)-dose acquisition (25 mCi) for 2 min and an ultra-low dose acquisition of 3 mCi for 5.44 min. The estimated left ventricle (LV) counts were compared with the available literature on a state-of-the-art system (DSPECT). FWHM of the LV wall on MPH-OSEM-reconstructed images with collimator resolution recovery was estimated. Results: On acquired rod-sources, the average resolution (FWHM) after reconstruction with resolution recovery in the entire region of interest (ROI) for cardiac imaging was on the average 4.44 mm (AE2.84), compared to 6.9 mm (AE1 mm) reported for GE Discovery (Kennedy et al., J Nucl Cardiol. 2014:21:443-452). For NCAT studies, improved sensitivity allowed a full-dose (25 mCi) 2-min acquisition (Ell8.68mmFD) which yielded 3.79 M LV counts. This is~3.35 times higher compared to 1.13 M LV counts acquired in 2 min for clinical full dose for state-of-the-art DSPECT. The increased sensitivity also allowed an ultra-low dose acquisition protocol (Ell8.68 mmULD), 3 mCi (eight times less injected dose) in 5.44 min. This ultra-low dose protocol yielded~1.23 M LV counts which was comparable to the full-dose 2-min acquisition for DSPECT. The estimated NCAT average FWHM at the LV wall after 12 iterations of the OSEM reconstruction was 4.95 and 5.66 mm...

show abstract

The prognosis of a normal Tl-201 stress-only SPECT MPI study

Cited by 18 publications

References 22 publications

Outcome of patients with high-risk Duke treadmill score and normal myocardial perfusion imaging on spect

Outcome of patients with high-risk Duke treadmill score and normal myocardial perfusion imaging on spect

Atualização da Diretriz Brasileira de Cardiologia Nuclear – 2020

Performance analysis of a high‐sensitivity multi‐pinhole cardiac SPECT system with hemi‐ellipsoid detectors

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