The prognosis and management of recurrent abdominal malignancies

Griffen, Ward O.; Humphrey, Loren J.; Sosin, Henry

doi:10.1016/s0011-3840(69)80008-0

Cited by 37 publications

(18 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As summarized by Griffen et al, routine secondlook laparotomy in high risk (Dukes' C primary) asymptomatic patients resulted in the salvage of 17% of patients with recurrent colon cancer and 10% of patients with recurrent rectal cancer (50). The data collected do not address the question of the efficacy of asymptomatic second-look laparotomy versus efficacy of symptom or follow-up test initiated laparotomy.…”

Section: Detection Of Colorectai Cancer Metastases After Curative Resmentioning

confidence: 97%

“…Knowledge of patterns of recurrence following curative resection of colorectal cancer primaries is essential to understand the causes and implications of treatment failure (Table 3) (48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58). In general, 50-70% of patients undergoing curative resections achieve a long-term disease free status (24,36,38,Authors Year 48, 50-55, 59, 60).…”

Section: Patterns Of Spread and Recurrence Of Colorectal Cancer Metasmentioning

confidence: 99%

“…Experience with such surgery is best analyzed by dividing it into the pre-CEA period and the current era in which CEA surveillance is widely utilized. Table 8 summarizes the experiences of 11 groups with reresection for locally or regionally recurrent tumor (50,56,61,70,71,86,(99)(100)(101)(102)Sugarbaker [unpublished results]). Prior to the use of CEA determinations to detect recurrences at an early stage resectability rates varied from 10-40%.…”

Section: Locally and Regionally Recurrent Colorectal Cancermentioning

confidence: 99%

See 2 more Smart Citations

Clinical perspective of human colorectal cancer metastasis

1984

View full text Add to dashboard Cite

Death from colorectal cancer frequently results from manifestations of recurrent local or metastatic disease following initial 'curative' therapy. Presently, the attempted curative treatment of recurrent colorectal cancer lays in the hands of the surgeon. This paper reviews the natural history of surgically treated large bowel cancer and summarizes published and National Cancer Institute experience with the surgical therapy of recurrent disease. A schema with rationale is offered for follow-up of the patient following 'curative' bowel resection. The treatment of recurrent disease incorporating the use of CEA initiated second-look laparotomy is advocated. Hepatic and pulmonary resections for metastatic disease are accepted as important therapeutic endeavours, and are discussed in some detail. It is concluded that of all patients diagnosed as having large bowel cancer, roughly 70% are resectable for cure at time of presentation, and 45% will indeed be cured by primary resection. Of the 25% who fail primary therapy, approximately 20% (5% of all colorectal cancer patients) can be cured by local re-resection or hepatic or pulmonary resection.

show abstract

Section: Detection Of Colorectai Cancer Metastases After Curative Resmentioning

confidence: 97%

Section: Patterns Of Spread and Recurrence Of Colorectal Cancer Metasmentioning

confidence: 99%

Section: Locally and Regionally Recurrent Colorectal Cancermentioning

confidence: 99%

See 1 more Smart Citation

Clinical perspective of human colorectal cancer metastasis

1984

View full text Add to dashboard Cite

show abstract

“…Thus, surgical reexploration to attempt the resection of recurrences and metastases was a uniquely reasonable therapeutic option for high-risk patients. Subsequently, the initial enthusiasm for this approach was dampened because of reports of a very low salvage rate among the reoperated patients [6,7]. More than 80% of patients failed to benefit from secondlook procedures; the risk/benefit ratio for these procedures needed to be improved by a better preoperative definition of a subpopulation of patients with localized and potentially resectable recurrences.…”

Section: Introductionmentioning

confidence: 99%

Radioimmunoguided surgery benefits in carcinoembryonic antigen-directed second-look surgery in the asymptomatic patient after curative resection of colorectal cancer

Bertoglio¹,

Benevento²,

Percivale³

et al. 1998

Semin. Surg. Oncol.

View full text Add to dashboard Cite

“…However, because there was no tumor marker, such as carcinoembryonic antigen (CEA), to indicate an appropriate time for operation, the arbitrary time span between first and second operation chosen by Wangensteen et al resulted in a high rate of negative explorations, low resectability rates, and little or no impact on survival (4). Thus, the concept was abandoned, but it has regained new interest since CEA-directed second-look procedures have shown improved survival (5)(6)(7).…”

mentioning

confidence: 99%