The prognosis and clinicopathology of CXCR4 in gastric cancer patients: a meta-analysis

Han, Mingzhi; Lv, Shunzeng; Zhang, Ya; Yi, Ruiyang; Huang, Bin; Fu, Hanhui; Bian, Ruixiang; Li, Xingang

doi:10.1007/s13277-013-1603-4

Cited by 19 publications

(17 citation statements)

References 20 publications

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“…Positive staining for CXCR4 was identified in 80% of the primary gastric tumor tissues (Han et al, 2014). CXCR4 expression in primary gastric carcinomas is associated with the development of peritoneal carcinomatosis and malignant ascites which contained high levels of CXCL12 (Yasumoto et al, 2006).…”

Section: Role Of Cxcr4 In Cancermentioning

confidence: 99%

“…A meta-analysis by Han et al showed that CXCR4 expression is associated with poor prognosis in gastric cancer patients. In this study, OS was found to significantly correlate with CXCR4 expression, with the HR of 2.63 (95% CI: 1.69–4.09; P <0.0001), and a significant association was also detected between CXCR4 expression and tumor stage (odd ratio (OR): 0.52, 95% CI: 0.32–0.83; P = 0.007), depth of invasion (OR: 0.44, 95% CI: 0.27–0.73; P = 0.001), lymph node metastasis (OR: 2.30, 95% CI: 1.57–3.36; P <0.0001), and vascular invasion (OR: 0.72, 95% CI: 0.53–0.98; P = 0.04) (Han et al, 2014). Fakhari et al (2014) reported that Helicobacter pylori infection increased CXCL12 secretion by gastric epithelial cell line, upregulated CXCR4 expression in bone marrow-derived-mesenchymal stem cells, and enhanced their migration toward CXCL12 gradient.…”

Section: Role Of Cxcr4 In Cancermentioning

confidence: 99%

See 1 more Smart Citation

The Intricate Role of CXCR4 in Cancer

Chatterjee

Azad

Nimmagadda

2014

Advances in Cancer Research

540

530

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Chemokines mediate numerous physiological and pathological processes related primarily to cell homing and migration. The chemokine CXCL12, also known as stromal cell-derived factor-1, binds the G-protein-coupled receptor CXCR4, which, through multiple divergent pathways, leads to chemotaxis, enhanced intracellular calcium, cell adhesion, survival, proliferation, and gene transcription. CXCR4, initially discovered for its involvement in HIV entry and leukocytes trafficking, is overexpressed in more than 23 human cancers. Cancer cell CXCR4 overexpression contributes to tumor growth, invasion, angiogenesis, metastasis, relapse, and therapeutic resistance. CXCR4 antagonism has been shown to disrupt tumor–stromal interactions, sensitize cancer cells to cytotoxic drugs, and reduce tumor growth and metastatic burden. As such, CXCR4 is a target not only for therapeutic intervention but also for noninvasive monitoring of disease progression and therapeutic guidance. This review provides a comprehensive overview of the biological involvement of CXCR4 in human cancers, the current status of CXCR4-based therapeutic approaches, as well as recent advances in noninvasive imaging of CXCR4 expression.

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Section: Role Of Cxcr4 In Cancermentioning

confidence: 99%

Section: Role Of Cxcr4 In Cancermentioning

confidence: 99%

The Intricate Role of CXCR4 in Cancer

Chatterjee

Azad

Nimmagadda

2014

Advances in Cancer Research

540

530

View full text Add to dashboard Cite

show abstract

“…High expression of CXCL12 is associated with reduced overall survival in GC patients (HR 2.08; 95% CI = 1.31-3.33; P = 0.0002) [73] . CXCR4 expression is associated with shorter overall survival (HR 2.63; 95% CI = 1.69-4.09; P < 0.001) [74] .…”

Section: Chemokinesmentioning

confidence: 99%

“…Oncotarget [28] FOXP3+ TILs (intra-tumoral) Tumour Biol [74] CXCL12 2.08 1.31-3.33 0.002 2017 Br J Cancer [73] MMPs MMP-2 1.92 1.48-2.48 < 0.001 2014…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Microenvironment in the pathogenesis of gastric cancer metastasis

Shinmoto¹,

Ishimoto²,

Baba³

2018

JCMT

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Tumor tissues contain cancer cells, other cellular and non-cellular components. Tumor microenvironments consist of cancer cells and various types of stromal cells, cancer associated fibroblasts, bone marrow-derived cells, endothelial cells, and hematopoietic cells, mainly tumor-associated macrophages and tumor-infiltrating lymphocytes. Increasing recent evidence has demonstrated that alteration of tumor microenvironments is deeply implicated in tumor progression and metastasis in gastric cancer (GC) patients. Recent investigations have provided insights into the molecular mechanisms of the interaction between tumor cells and tumor microenvironments. Interactions between cancer cells and their microenvironment with cytokines and microRNA in extracellular vesicles, such as the exosome, can have a substantial impact on tumor characteristics. Alterations in the tumor microenvironment may play a crucial role in facilitating the progression of tumor cells and metastasis, as well as the activation of cell signaling pathways, which are associated with GC cell proliferation and invasion by genetic or epigenetic alterations. In this review, significant molecular insights into the tumor microenvironment, which consist of cancer associated fibroblasts, bone marrow-derived cells, tumor-associated macrophages and tumor-infiltrating lymphocytes; the interactions between cancer cells and their microenvironment; and the clinical impacts of alterations of GC microenvironments will be discussed.

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“…CXCR4 potentiates growth, angiogenesis/angiostasis, invasion/ metastasis and prognosis of various cancers, including esophageal cancer, renal cancer, breast cancer, colorectal carcinoma, glioma, gastric cancer and ovarian cancer [1][2][3][4][5][6][7][8]. CXCR4 is significantly associated with tumor stage, lymph node status, distant metastasis and poor survival [1,[3][4][5][6]8,9].…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers

Qing¹,

Wen²

2016

J Integr Oncol

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Purpose: Recently, higher expression of chemokine receptors in patients with various cancer types has been observed and indicated to have prognostic significance in the clinical progression of cancers. Former research has determined that CXCR7, as a member of chemokine receptor C-X-C family, empowers greater affinity with chemokine CXCL12 than CXCR4. The present study investigated the correlation of clinical characteristics and CXCR7 expression in cancers using meta-analysis. Methods:A comprehensive search on Pubmed and Web of Science identified CXCR7-related clinical studies. Methodological quality of these studies was evaluated and all the data were extracted, calculated and analyzed. This meta-analysis was carried out with Stata 12.0. Results:Fifteen eligible studies consisting of 1780 participants were included. The results showed that CXCR7 significantly relates to tumor occurrence (pooled RR=3.12, 95% CI: 1.71-5.70, P=0.000), tumor grades (pooled RR=1.41, 95% CI: 1.14-1.75, P=0.002), tumor stages (pooled RR=1.51, 95% CI: 1.26-1.82, P=0.000) and lymph node metastasis (pooled RR=1.49, 95% CI: 1.14-1.94, P=0.000), respectively. Conclusion:Highly expressed chemokine receptor CXCR7 potentially increases tumor occurrence risk. Higher CXCR7 expression is associated with poorer prognosis, advanced stages, differentiation grades and poor lymph node metastasis in patients with various cancers. Thus, highly expressed CXCR7 could be a potential biomarker in the prognosis of cancers.

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The prognosis and clinicopathology of CXCR4 in gastric cancer patients: a meta-analysis

Cited by 19 publications

References 20 publications

The Intricate Role of CXCR4 in Cancer

The Intricate Role of CXCR4 in Cancer

Microenvironment in the pathogenesis of gastric cancer metastasis

Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers

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