The Profile of Neonatal Sepsis in Duhok City and Predictors of Mortality: A Prospective Case Series Study

Abstract

Background: Neonatal sepsis is a major cause of death all over the world. Risk factors represent an interaction between maternal immunity and the defense mechanisms of the neonate. epidemiological, clinical and laboratory profiles of neonates with sepsis in relation to outcome and to determine the predictors of outcome. Subject and Methods: A prospective study included neonates with sepsis admitted to neonatal care unit. 126 neonates with features of sepsis were included with age ranged from (1-30) days. From each patient, neonatal and maternal data were collected and clinical features as well as laboratory test results of hemoglobin, platelets count. total white blood cell and absolute neutrophil count , C statistically analyzed. Results: of 126 neonates, 32 (25.39%) died while others survived. Age < 7 days was in 61.9% of all cases, 69.84% had respiratory distress syndr encephalopathy, 60.31% were preterm, 61.9% were born vaginally and male to female ratio was 1.73:1. There is a significant relation of mortality to respiratory distress syndrome and hypoxic ischemic encephalopathy, preterm d Vomiting, apnea, sclerema, cyanosis and tachypnea were significantly related to the mortality. Eschericia coli were mortality is with Acenatobacterbaumani relation. The C reactive protein was>10 mg/dl was in higher number of neonates with sepsis who died by comparison to those who survived, with a significant relation. Conclusions: Neonatal sepsis is still a c the pattern of causative organisms and this requires more monitoring and periodic surveillance. There is a real need to find out the local antibiotic sensitivities of pat establish an optimal empirical treatment before the results of culture and sensitivity are available.

Time to Death and Its Predictors among Neonates Hospitalized with Sepsis in Eastern Ethiopia

“…Not surprisingly, low birthweight neonates have a higher risk of mortality than term and normal birthweight neonates. Similar findings were reported in a systematic review and meta-analysis of mortality from neonatal sepsis [ 6 ], and other studies conducted in Brazil [ 14 ], Iraq [ 20 ], Central India [ 21 ], Pakistan [ 22 ], and Ethiopia [ 15 , 23 , 24 ]. This is because low birthweight may relate with prematurity; the immune system of preterm neonates is not well developed.…”

Frequency, Bacteriological Profile, and Outcome of Neonatal Sepsis with Carbapenem-Resistant Gram-Negative Bacteria at the Tertiary Neonatal Intensive Care Unit, Ahvaz, Iran

“…In our study, the mortality rate of premature infants with a gestational age of fewer than 32 weeks was higher than that of infants with a gestational age of more than 32 weeks. This finding is comparable to studies conducted in Ethiopia and Iraq and a systematic review conducted in developing countries (30)(31)(32). Preterm neonates are more likely to die than term neonates due to a lack of various immune system components, despite many aggressive measures to preserve their lives.…”