The Profile of Epilepsy and its characteristics in Children with Cerebral Palsy

Archana, K; Saini, Lokesh; Gunasekaran, Pradeep Kumar; Singh, Paramjeet; Sahu, Jitendra Kumar; Sankhyan, Naveen; Sharma, Rajni; Bhati, Ankita; Yadav, Jaivinder; Sharawat, Indar Kumar

doi:10.1016/j.seizure.2022.08.009

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…It was found that 36.9% and 10.8% of CP patients had controlled epilepsy and DRE, respectively. Previous studies showed that 10% to 27% of CP patients had drug resistance [2,5,[7][8][9][10]17]. The risk factors for drug-resistant and controlled epilepsy were similar for most variables, except for occipitofrontal circumference (P<0.001) and brain imaging findings.…”

Section: Subgroup Analysis By Drug Resistancementioning

confidence: 72%

“…A study in Canada based on CP registry also showed similar results, with more preterm patients with CP in the non-epilepsy group [15]. Studies in Australia, Turkey Poland, and India also reported more preterm patients in the non-epilepsy group, albeit without statistical significance [2,10,16,17]. These results seem to contradict the well-known fact that prematurity is a risk factor for CP [1,4].…”

Section: Risk Factors For Epilepsy In Cerebral Palsymentioning

confidence: 88%

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Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Yeo,

Han,

Kim

2023

Ann Child Neurol

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Purpose: The aim of this study was to describe the characteristics of epilepsy in cerebral palsy (CP) patients and identify risk factors for epilepsy and drug-resistant epilepsy.Methods: CP patients aged 18 years old or younger who visited the pediatric neurology department and/or rehabilitation department of a tertiary care hospital between January 2016 and December 2022 with a minimum follow-up period of 2 years were included. Demographic and clinical data, seizure characteristics, brain imaging, electroencephalography, and genetic evaluation results were reviewed retrospectively.Results: Among 268 patients included in this study, 36.9% had epilepsy and 10.8% had drug-resistant epilepsy. Asphyxia (29.3%), hemorrhage, infarction, and brain infection (25.3%) were associated with epilepsy. Epileptic CP patients were more likely to experience neonatal seizures (18.2% vs. 4.1%, <i>P</i><0.001) and febrile seizures (12.1% vs. 7.1%, <i>P</i>=0.02) than non-epilepsy CP patients. The most common cerebral subtype in patients with epilepsy was spastic quadriplegia (59.6%). Epilepsy patients were more severely impaired in gross motor function, with worse intellectual disability. Patients with macrocephaly or cerebral malformation were more likely to have drug resistance. Valproate (51.7% and 25.7%) and levetiracetam (41.4% and 25.7%) were the two most commonly used antiseizure medications, both in monotherapy and polytherapy.Conclusion: A history of asphyxia, febrile seizure, neonatal seizure, spastic quadriplegia, more severely impaired gross motor function, and intellectual disability were found to be risk factors for epilepsy. Further research with prospective data collection to develop a model for predicting seizures or epilepsy in CP patients is needed.

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Section: Subgroup Analysis By Drug Resistancementioning

confidence: 72%

Section: Risk Factors For Epilepsy In Cerebral Palsymentioning

confidence: 88%

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Yeo,

Han,

Kim

2023

Ann Child Neurol

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Section: Discussionmentioning

confidence: 99%

“…Individuals with cerebral palsy have a significantly higher risk of developing epilepsy when compared to the general population, with seizure rates reaching 20%-45% in children with CP [ 12 ]. In these cases, the first seizure is 50%-60% more likely to occur within the first year of life [ 12 ]. Neuroimaging of children with CP demonstrates significantly less brain volume, as well as changes in the basal ganglia and periventricular leukomalacia [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…In these cases, the first seizure is 50%-60% more likely to occur within the first year of life [ 12 ]. Neuroimaging of children with CP demonstrates significantly less brain volume, as well as changes in the basal ganglia and periventricular leukomalacia [ 12 ]. The complete lack of seizure activity throughout this patient's early life, coupled with previously unremarkable brain imaging, further supports our claim that his recent onset of seizures was directly related to a COVID-19 infection.…”

Section: Discussionmentioning

confidence: 99%

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Late-Onset Seizure Disorder in Adult Cerebral Palsy Associated With COVID-19 Infection

McCauley¹,

Li²,

Kobrin³

2023

Cureus

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COVID-19 can affect many organ systems, including the CNS, with symptoms of altered mental status and seizures. We present a case of a 30-year-old man with cerebral palsy who developed seizures after a COVID-19 infection. Admission labs were remarkable for hypernatremia, and elevated creatine kinase, and troponin levels as well as creatinine above baseline. MRI was performed demonstrating a small, evolving acute/subacute abnormality in the midline splenium of the corpus callosum. An EEG showed moderate to severe abnormalities with low-voltage delta waves. The patient was treated with medication and advised to follow up with a neurologist. One month later, no residual CT abnormality corresponding to the previously reported lesion in the midline splenium of the corpus callosum was observed. Although epilepsy is a common finding in patients with cerebral palsy, the complete lack of seizure activity throughout this patient's early life, coupled with previously unremarkable brain imaging, further supports our claim that his recent onset of seizures was directly related to COVID-19. This case highlights the possibility of new seizures in patients with pre-existing neurological conditions after COVID-19 infection and emphasizes the need for more research.

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Efficacy of daily versus intermittent low glycemic index therapy diet in children with drug-resistant epilepsy: A randomized controlled trial

Panda,

Chakrabarty,

Jauhari

et al. 2024

Epilepsy Research

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The Profile of Epilepsy and its characteristics in Children with Cerebral Palsy

Cited by 9 publications

References 31 publications

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Characteristics of Epilepsy in Children with Cerebral Palsy: A Single Tertiary Center Study

Late-Onset Seizure Disorder in Adult Cerebral Palsy Associated With COVID-19 Infection

Efficacy of daily versus intermittent low glycemic index therapy diet in children with drug-resistant epilepsy: A randomized controlled trial

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