The professors of ophthalmology at the University of Leipzig in the first half of the 20th century

Sachsenweger, R

doi:10.1007/978-94-009-1307-3_12

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results presented here explicitly are for p close to 0.078, where it is easier to initiate a reorganization of the pattern, but we have also studied a broader range of p . Simulations for longer bitstrings up to d = 22 have shown that many features are also found in larger networks and the major concepts of structural analysis are still applicable ( 64 ). The program code is implemented in C++.…”

Section: The Modelmentioning

confidence: 99%

Self-Tolerance in a Minimal Model of the Idiotypic Network

2014

View full text Add to dashboard Cite

We consider the problem of self-tolerance in the frame of a minimalistic model of the idiotypic network. A node of this network represents a population of B-lymphocytes of the same idiotype, which is encoded by a bit string. The links of the network connect nodes with (nearly) complementary strings. The population of a node survives if the number of occupied neighbors is not too small and not too large. There is an influx of lymphocytes with random idiotype from the bone marrow. Previous investigations have shown that this system evolves toward highly organized architectures, where the nodes can be classified into groups according to their statistical properties. The building principles of these architectures can be analytically described and the statistical results of simulations agree very well with results of a modular mean-field theory. In this paper, we present simulation results for the case that one or several nodes, playing the role of self, are permanently occupied. These self nodes influence their linked neighbors, the autoreactive clones, but are themselves not affected by idiotypic interactions. We observe that the group structure of the architecture is very similar to the case without self antigen, but organized such that the neighbors of the self are only weakly occupied, thus providing self-tolerance. We also treat this situation in mean-field theory, which give results in good agreement with data from simulation. The model supports the view that autoreactive clones, which naturally occur also in healthy organisms are controlled by anti-idiotypic interactions, and could be helpful to understand network aspects of autoimmune disorders.

show abstract

Section: The Modelmentioning

confidence: 99%