The Professor is Not a Teacher

Pharmaceutical Sciences—1972: Literature Review of Pharmaceutics II‡‡Editor' s note: Part I of this article appeared in the July 1973 issue of the Journal of Pharmaceutical Sciences.

“…Selection of a particular base vehicle for topical formulation of each individual drug to obtain optimum therapeutic activity was demonstrated by comparing activities of fluocinonide and fluocinolone acetonide in the same vehicle with intrinsic activities of the drugs. Fluocinolone acetonide was readily released from the base and exhibited significant clinical effectiveness; however, fluocinonide activity was considerably reduced because of poor drug release from the base (1339). Ointment preparations of betamethasone 17-benzoate in white soft paraffin and propylene glycol or in white paraffin and isopropyl myristate showed higher vasoconstrictor activity in humans than five other ointments tested, including water-miscible ointments based on polyethylene glycols (macrogols) (1 340).…”