The production of patient dose level<sup>99m</sup>Tc medical radioisotope using laser-driven proton beams

Clarke, R.J.; Dorkings, S.; Neely, D.; Musgrave, Ian

doi:10.1117/12.2016971

Cited by 8 publications

(4 citation statements)

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“…Whereas a study of the direct production of Tc-99m on cyclotrons has begun quite long ago since pioneering work by Beaver and Hupf (1971), the works on a laser approach to Tc-99m production are just beginning (Clarke et al, 2014). We believe that Tc-99m production with ultrashort intense laser pulses is potential alternative moving forward to create new source of supply of Tc-99m for decades to come.…”

Section: Discussionmentioning

confidence: 98%

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Tc-99m production with ultrashort intense laser pulses

Bychenkov¹,

Brantov²,

Mourou³

2014

Laser Part. Beams

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The interaction of a relativistic short laser pulse with thin foil is studied using 3D PIC simulations in the context of optimized high-energy proton generation for nuclear medicine and pharmacy. As an example, we analyze the Tc-99m yield from the Mo-100(p,2n)Tc-99m reaction with the International Coherent Amplification Network (ICAN) concept defined by a 10 J pulse energy and 10 kHz repetition rate. Based on 3D PIC simulation it has been demonstrated that normally incident 100 fs laser pulse with maximum intensity of 5 × 10 21 W/cm 2 is able to generate 10 11 protons with energy upto 45 MeV from thin semi-transparent CH 2 target. Such laser-produced proton beam after 6 hours bombardment of the thick metallic Mo-100 target gives around 300 Gbq activities of Tc-99m isotope. This gives reason to believe that laser technology for producing technetium is possible with ICAN concept to replace the traditional scheme through the fission of weapons-grade uranium.

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Section: Discussionmentioning

confidence: 98%

“…This technique permits producing Tc-99m from the Mo-100(p,2n)Tc-99m reaction (Clarke et al, 2014). This technique permits producing Tc-99m from the Mo-100(p,2n)Tc-99m reaction (Clarke et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Tc-99m production with ultrashort intense laser pulses

Bychenkov¹,

Brantov²,

Mourou³

2014

Laser Part. Beams

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“…These accelerators are primarily under development for high energy physics applications, but have the potential for future broader applications in radioisotope production (Leemans 2001, Reed 2007, Clarke 2013. High power, short pulse lasers interact with gas-sourced plasma targets, from either a gas jet, a preformed capillary plasma channel (Gonsalves, 2007) to guide the laser pulse and extend the accelerating length of the electrons, or a gas jet coupled to a capillary to control both the electron injection and laser guiding (Gonsalves 2011).…”

Section: Methodsmentioning

confidence: 99%

Measured bremsstrahlung photonuclear production of 99Mo (99mTc) with 34 MeV to 1.7 GeV electrons

Roberts

Geddes

Matlis

et al. 2015

Applied Radiation and Isotopes

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(99)Mo photonuclear yield was measured using high-energy electrons from Laser Plasma Accelerators and natural molybdenum. Spectroscopically resolved electron beams allow comparisons to Monte Carlo calculations using known (100)Mo(γ,n)(99)Mo cross sections. Yields are consistent with published low-energy data, and higher energy data are well predicted from the calculations. The measured yield is (15±2)×10(-5) atoms/electron (0.92±0.11 GBq/μA) for 25 mm targets at 33.7 MeV, rising to (1391±20)×10(-5) atoms/electron (87±2 GBq/μA) for 54 mm/ 1.7 GeV, with peak power-normalized yield at 150 MeV.

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“…The cost of this effect is a reduction in the maximum proton energy. For distinct applications which do not need high proton energies but a high proton flux with a shaped beam profile (e.g., proton beam writing 34 or radioisotope production 35 ), this method might be sufficient to at least preform the beam profile before using collimators to create the desired shape. This enhances the process efficiency and reduces the number of protons which need to be dumped away creating unnecessary activation or radiation at the collimator.…”

Section: -6mentioning

confidence: 99%

Manipulation of the spatial distribution of laser-accelerated proton beams by varying the laser intensity distribution

et al. 2016

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We report on a study of the spatial profile of proton beams produced through target normal sheath acceleration (TNSA) using at target foils and changing the laser intensity distribution on the target front surface. This is done by either defocusing a single laser pulse or by using a split-pulse setup and irradiating the target with two identical laser pulses with variable spatial separation. The resulting proton beam profile as well as the energy spectrum are recorded as functions of the focal spot size of the single laser pulse and of the separation between the two pulses. A shaping of the resulting proton beam profile, related to both an increase in ux of low-energy protons in the target normal direction and a decrease in their divergence, in one or two dimensions, is observed. The results are explained by simple modelling of rear surface sheath field expansion, ionization and projection of the resulting proton beam

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The production of patient dose level^99mTc medical radioisotope using laser-driven proton beams

Cited by 8 publications

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Tc-99m production with ultrashort intense laser pulses

Tc-99m production with ultrashort intense laser pulses

Measured bremsstrahlung photonuclear production of 99Mo (99mTc) with 34 MeV to 1.7 GeV electrons

Manipulation of the spatial distribution of laser-accelerated proton beams by varying the laser intensity distribution

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The production of patient dose level99mTc medical radioisotope using laser-driven proton beams

Cited by 8 publications

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Tc-99m production with ultrashort intense laser pulses

Tc-99m production with ultrashort intense laser pulses

Measured bremsstrahlung photonuclear production of 99Mo (99mTc) with 34 MeV to 1.7 GeV electrons

Manipulation of the spatial distribution of laser-accelerated proton beams by varying the laser intensity distribution

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Product

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The production of patient dose level^99mTc medical radioisotope using laser-driven proton beams