The production of interleukin-1α immunoreactivity by human oviductal cells in a coculture system

Yeung, William S.B.; Lau, Esther Yuet Ying; Chan, Anita; Ho, Pak‐Chung

doi:10.1007/bf02066496

Cited by 12 publications

(8 citation statements)

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“…Studies in humans as well as in animal models demonstrate that co-culture of oviductal epithelial monolayers with preimplantation embryos of the same species improves fertilization and quality of the inner cell mass, increases total embryo cell numbers and improves implantation rates (Bongso et al , 1992; Kervancioglu et al , 1997; Vlad, Walker, and Kennedy, 1996; Yeung et al , 1996; Yeung et al , 1992). Clinically, assisted reproduction technology such as IVF–embryo transfer and intracytoplasmic sperm injection have enabled bypassing the oviduct for conception with tubal factor infertility and severe male factor infertility, respectively (Palermo et al , 1992).…”

Section: Introductionmentioning

confidence: 99%

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

Hess

Talbi

Hamilton

et al. 2013

Reproductive BioMedicine Online

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The human oviduct serves as a conduit for spermatozoa in the periovulatory phase and nurtures and facilitates transport of the developing embryo for nidation during the luteal phase. Interactions between the embryo and oviductal epithelial surface proteins and secreted products during embryo transit are largely undefined. This study investigated gene expression in the human oviduct in the early luteal versus follicular phases to identify candidate genes and biomolecular processes that may participate in maturation and transport of the embryo as it traverses this tissue. Oviductal RNA was hybridized to oligonucleotide arrays and resulting data were analysed by bioinformatic approaches. There were 650 genes significantly down-regulated and 683 genes significantly up-regulated (P < 0.05) in the luteal versus follicular phase. Quantitative real-time PCR, immunoblot analysis and immunohistochemistry confirmed selected gene expression and cellular protein localization. Down-regulated genes involved macrophage recruitment, immunomodulation and matrix-degeneration, and up-regulated genes involved anti-inflammatory, ion transport, anti-angiogenic and early pregnancy recognition. The oviduct displayed some similarities and differences in progesterone-regulated genes compared with the human endometrium. Together, these data suggest a unique hormonally regulated environment during embryo development, maturation and transport through human oviduct and some conservation of progesterone signalling in tissues of common embryological origin.

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Section: Introductionmentioning

confidence: 99%

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

Hess

Talbi

Hamilton

et al. 2013

Reproductive BioMedicine Online

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“…Evidence is accumulating that interaction exists between the embryo and the female reproductive tract before implantation [Downing et al, 2002;Lee et al, 2002;Wolf et al, 2003]. This interaction can be achieved via the paracrine growth factors (reviewed in [Hardy and Spanos, 2002]) and/or cytokines including interleukin-1 alpha [Yeung et al, 1996], insulin-like growth factor-binding proteins [Lai et al, 1996;Watson et al, 1999], vascular endothelial growth factor and receptors [Gabler et al, 1999], transforming growth factor-b , platelet-activating factor [Downing et al, 2002], embryotrophic factors (ETFs) [Mermillod et al, 1993;Liu et al, 1995;Yeung et al, 2002;Lee et al, 2004], and other factor/peptide of unknown identity .…”

mentioning

confidence: 99%

Phospholipid transfer protein (PLTP) mRNA expression is stimulated by developing embryos in the oviduct

Lee

Kwok

Chung

et al. 2005

J of Cellular Biochemistry

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In mammal, fertilization and early preimplantation embryo development occurs in the oviduct. Evidence is accumulating that the oviductal epithelia secrete various biomolecules to the lumen during the secretory phase of the estrus cycle to enhance embryo development. This secretory activity of the oviduct is under the regulation of steroid hormones. Observations also suggested that the gametes and embryos modulate the physiology and gene-expressing pattern of the oviduct. However, the underlying molecular changes remain elusive. We hypothesize that the developing embryos interact with the surrounding environment and affect the gene expression patterns of the oviduct, thereby modulating the oviductal secretory activity conducive to the preimplantation embryo development. To test this hypothesis, suppression subtractive hybridization (SSH) was used to compare the gene expressions in mouse oviduct containing transferred in vitro cultured preimplantation embryos with that of oviduct containing oocytes during the preimplantation period. We reported here the identification and characterization of phospholipids transfer protein (PLTP), which is highly expressed in the embryo-containing oviduct and localized at the oviductal epithelium by in situ hybridization. PLTP contains signal peptide putative for secretory function. More importantly, PLTP mRNA increases in the oviductal epithelia of pregnant, but not pseudo-pregnant mice when assayed by real-time PCR. Taken together, our data suggested that PLTP may play important role(s) during in vivo preimplantation embryo development. This molecule would be a target to delineate the mechanisms and the roles of oviductal secretory proteins on early embryonic development.

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“…2005). Studies in other species suggest that this interaction between gametes or embryos and oviduct can be achieved via the paracrine action of growth factors and/or cytokines including IL‐1α (Yeung et al. 1996), insulin‐like growth factor‐binding proteins (IGFBPs; Lai et al.…”

Section: Pre‐ and Post‐conception Periodmentioning

confidence: 99%

“…T reg -T regulatory cells, NK -natural killer cells, AA -arterio-arterial anastomoses connecting uterine and ovarian arteries (modified from Kaczmarek et al 2010) Recognition of gametes, seminal plasma components and embryos in the oviduct Gametes and embryos modulate the gene expression pattern and function of the oviduct (Georgiou et al 2005). Studies in other species suggest that this interaction between gametes or embryos and oviduct can be achieved via the paracrine action of growth factors and ⁄ or cytokines including IL-1a (Yeung et al 1996), insulin-like growth factor-binding proteins (IGFBPs; Lai et al 1996;Watson et al 1999), vascular endothelial growth factor (VEGF) and its receptors (Gabler et al 1999), TGFb (Chow et al 2001), platelet-activating factor (Downing et al 2002), embryotrophic factors (ETFs) (McCauley et al 2003) and other factors ⁄ peptides of unknown identity (Bauersachs et al 2003).…”

Section: Pre-and Post-conception Periodmentioning

confidence: 99%

Mechanisms for the Establishment of Pregnancy in the Pig

Ziȩcik

Wacławik

Kaczmarek

et al. 2011

Reprod Domestic Animals

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ContentsEstablishment of pregnancy in pigs requires continuous function of corpora lutea and endometrial preparation for embryo implantation. Progesterone regulates expression of many proteins necessary for endometrial remodelling and embryo-maternal communications. Attaining the uterine receptivity involves progesterone priming and loss of progesterone receptors in the uterine epithelium before days 10-12 after oestrus. Spermatozoa and oocytes in oviduct alter secretion of specific proteins that exert beneficial effect on gametes and embryos. Moreover, an appropriate leucocyte activation and maintenance of delicate cytokine balance within the oviduct and uterus are important for early pregnancy. This early local immune response is rather mediated by seminal plasma components. These components also influence prostaglandin (PG) synthesis in the oviduct that is important for gamete and embryo transport. Pregnancy establishment requires the biphasic pattern of oestrogen secretion by conceptuses on days 11-12 and 15-30. Conceptus affects lipid signalling system consisting of prostaglandins and lysophosphatic acid. PG synthesis is changed by conceptus signals in favour of luteoprotective PGE 2 . Additionally, existence of PGE 2 positive feedback loop in the endometrium contributes to increased PGE 2 ⁄ PGF 2a ratio during the peri-implantation period. PGE 2 through endometrial PGE 2 receptor (PTGER2) elevates the expression of enzymes involved in PGE 2 synthesis. Higher PGE 2 secretion in uterine lumen coincides with the elevated expression of HOXA10 transcription factor critical for implantation. A stable adhesion between conceptus and endometrium requires reduction in mucin-1 on the apical surface of epithelium and integrin activation by extracellular matrix proteins. Furthermore, growth factors, cytokines and its receptors are involved in embryo-maternal interactions.

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The production of interleukin-1α immunoreactivity by human oviductal cells in a coculture system

Abstract: These data showed that human oviductal cells produced interleukin-1 alpha immunoreactivity in a coculture system. However, this production could not be used as a marker for successful embryo implantation.

Cited by 12 publications

References 13 publications

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

The human oviduct transcriptome reveals an anti-inflammatory, anti-angiogenic, secretory and matrix-stable environment during embryo transit

Phospholipid transfer protein (PLTP) mRNA expression is stimulated by developing embryos in the oviduct

Mechanisms for the Establishment of Pregnancy in the Pig

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