The production of hydroxyapatite prototypes from solid bodies of gypsum/polyvinyl alcohol composites

Barbosa, Amanda Alves; Ferraz, Andréa de Vasconcelos; Dantas, Alan Christie da Silva; Olivier, Nelson Cárdenas

doi:10.1590/s1516-14392014005000062

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Mechanical properties of samples produced by conversion of gypsum bodies into HA were reported to present similar results in comparison with this work [11], where a compressive strength of 3.5 ± 0.1 MPa for a final porosity of 80% was obtained there. HA-PS 1.48 ± 0.17 0.06 ± 0.01 70 ± 3…”

supporting

confidence: 87%

“…4A, where disc like crystals can be seen. These morphology has been reported on literature and attributed to HA produced by temperatures between 100 and 120°C [11]. The elementar analyze is showed on Fig.…”

supporting

confidence: 79%

“…All of the reagents used in the synthesis were of analytical degree. The conversion of the gypsum bodies into HA was carried out according to Barbosa et al [11]. The porous gypsum bodies were immersed in 200 mL of solution 0.5 mol.L -1 of (NH 4 ) 2 HPO 4 and the reaction temperature was controlled on 100 ºC.…”

Section: Synthesis Of Monophasic Ha Porous Bodiesmentioning

confidence: 99%

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Production of Single-Phase Hydroxyapatite Porous Bodies from Gypsum/Polystyrene

Barbosa

Ferraz

Santos

et al. 2016

MSF

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Porous bodies were produced using hydroxyapatite as a starting material, gypsum, high purity material, low cost and that can be molded into the desired shape. Also, beads of polystyrene polymer. The first step of this work was to produce porous gypsum blocks obtained by mixing gypsum, water and polystyrene. After drying, they were submerged in acetone solvent for solubilizing the polymer and pore formation. The porous hydroxyapatite was synthesized in a second stage, where the porous gypsum blocks were immersed in a solution of (NH4)2HPO4 0.5 mol L-1 to 100 ° C and pH 7.0-9.0 for 24 hours. From this method, it was possible to produce bodies single phase hydroxyapatite with a maximum porosity of 70 ± 3% and a compressive strength of 1.48 ± 0.17 MPa.

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supporting

confidence: 87%

supporting

confidence: 79%

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Production of Single-Phase Hydroxyapatite Porous Bodies from Gypsum/Polystyrene

Barbosa

Ferraz

Santos

et al. 2016

MSF

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“…Gypsum is a material that is highly moldable when in paste form, allowing solid bodies of previously defined shapes to be obtained [6]. Hydroxyapatite, on the other hand, is difficult to be molded in complex shapes due to its high fragility, which is directly related to the elevated crystallinity of the material [7,8].…”

Section: Introductionmentioning

confidence: 99%

Chemical conversion of a solid body of the composite gypsum/polyhydroxybutyrate in hydroxyapatite/polyhydroxybutyrate

et al. 2019

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The transformation of the gypsum into hydroxyapatite allows added value to this raw material, because the ceramic obtained has a high commercial value in relation to gypsum, while the polymer adds biocompatibility and bioactivity properties to the biocomposite. Thus, hydroxyapatite/polyhydroxybutyrate composites were prepared from the gypsum/polyhydroxybutyrate, using a 10% mass ratio of the polymer. The material was obtained by means of a chemical conversion carried out in a solution of ammonium hydrogen phosphate (0.5 mol.L-1) and alkaline medium (ammonium hydroxide 6.0 mol.L-1) for pH control. The reaction occurred at 100 °C at different test times. Analyzes of infrared spectroscopy showed functional groups characteristic of hydroxyapatite after 36 h of reaction; in addition, the biomaterial was identified as the major phase in X-ray diffraction patterns. Scanning electron microscopy of the materials before and after conversion showed a clear change in their morphologies, indicating the success of the synthesis.

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A new biocompatible delivery scaffold containing heparin and bone morphogenetic protein 2

Thanyaphoo

Kaewsrichan

2016

Acta Pharmaceutica

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A new biocompatible delivery scaffold containing heparin and bone morphogenetic protein 2Silicon-substituted calcium phosphate (Si-CaP) was developed in our laboratory as a biomaterial for delivery in bone tissue engineering. It was fabricated as a 3D-construct of scaffolds using chitosan-trisodium polyphosphate (TPP) cross-linked networks. In this study, heparin was covalently bonded to the residual -NH 2 groups of chitosan on the scaffold applying carbodiimide chemistry. Bonded heparin was not leached away from scaffold surfaces upon vigorous washing or extended storage. Recombinant human bone morphogenetic protein 2 (rhBMP-2) was bound to conjugated scaffolds by ionic interactions between the negatively charged SO 4 2-clusters of heparin and positively charged amino acids of rhBMP-2. The resulting scaffolds were inspected for bone regenerative capacity by subcutaneous implanting in rats. Histological observation and mineralization assay were performed after 4 weeks of implantation. Results from both in vitro and in vivo experiments suggest the potential of the developed scaffolds for bone tissue engineering applications in the future.

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The production of hydroxyapatite prototypes from solid bodies of gypsum/polyvinyl alcohol composites

Cited by 3 publications

References 8 publications

Production of Single-Phase Hydroxyapatite Porous Bodies from Gypsum/Polystyrene

Production of Single-Phase Hydroxyapatite Porous Bodies from Gypsum/Polystyrene

Chemical conversion of a solid body of the composite gypsum/polyhydroxybutyrate in hydroxyapatite/polyhydroxybutyrate

A new biocompatible delivery scaffold containing heparin and bone morphogenetic protein 2

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