The production and prevention of dental caries

Agnew, Mary Caldwell; Agnew, R. Gordon; Tisdall, Frederick F.

doi:10.1016/s0022-3476(33)80202-2

Cited by 16 publications

(10 citation statements)

References 15 publications

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“…Fifty‐three references were evaluated in detail, 24 of which were excluded because of the absence of incident caries outcome statistics, the lack of assignment to vitamin D by the investigator for the purpose of caries control, or the lack of controls . Twenty‐nine references remained, which included articles, abstracts, and excerpts of grant reports . In one reference that reported on three CCTs, one CCT without reported follow‐up time was eliminated.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

2012

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Vitamin D has been used to prevent and treat dental caries. The objective of this study was to conduct a systematic review of controlled clinical trials (CCTs) assessing the impact of vitamin D on dental caries prevention. Random-effects and meta-regression models were used to evaluate overall and subgroup-specific relative-rate estimates. Twenty-four CCTs encompassing 2,827 children met the inclusion criteria. Twenty-two of the 24 CCTs predated modern clinical trial design, some of which nonetheless reported characteristics such as pseudo-randomization (n = 2), blinding (n = 4), or use of placebos (n = 8). The relative-rate estimates of the 24 CCTs exhibited significant heterogeneity (P < 0.0001), and there was evidence of significant publication bias (P < 0.001). The pooled relative-rate estimate of supplemental vitamin D was 0.53 (95% CI, 0.43-0.65). No robust differences were identified between the caries-preventive effects of vitamin D(2) , vitamin D(3) , and ultraviolet radiation (Prob > F = 0.22). The analysis of CCT data identified vitamin D as a promising caries-preventive agent, leading to a low-certainty conclusion that vitamin D may reduce the incidence of caries.

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Section: Resultsmentioning

confidence: 99%

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

2012

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“…However, most of the authors overlooked very important facts: (1) No standard values for normal composition of mixed saliva have ever been established. (2) In examining cases with pathologic lesions of the oral cavity (caries, paradentosis, etc.…”

Section: Discussionmentioning

confidence: 99%

“…In the evaluation of former salivary analyses, four fundamental questions must be considered: (1) What is the physiologic composition of saliva; its physical and biochemical properties? (2) What changes occur under pathologic conditions; the effect of these conditions on physical and biochemical properties?…”

Section: Introductionmentioning

confidence: 99%

I. Critical Discussion of Former Salivary Calcium Studies and their Value in the Establishment of Normal Standards

Becks

Wainwright

1934

J Dent Res

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“…When these methods were tried on saliva several difficulties were encountered which interfered with accurate checks. 4. Poor color development was pronounced by the methods of Bell-Doisy; and Fiske and Subbarow.…”

Section: Recommended Methods For the Determination Of Salivary Inorganmentioning

confidence: 95%

Human Saliva

Wainwright

1938

J Dent Res

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The production and prevention of dental caries

Cited by 16 publications

References 15 publications

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis

I. Critical Discussion of Former Salivary Calcium Studies and their Value in the Establishment of Normal Standards

Human Saliva

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