The production and application of hydrogels for wound management: A review

Gupta, Abhishek; Kowalczuk, Marek; Heaselgrave, Wayne; Britland, Stephen; Martin, Claire; Radecka, Iza

doi:10.1016/j.eurpolymj.2018.12.019

Cited by 225 publications

(141 citation statements)

References 214 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…The potential of hydrogels for the treatment of skin wounds has been extensively explored in the last few years [ 91 ]. Besides the ability to absorb exudates, isolate the wound, and mimic the three-dimensional structure of tissues, their cross-linked structure enables the incorporation of different bioactive agents [ 91 , 92 ]. In addition, hydrogels can be injected directly on the wound, matching any shape of the defect site.…”

Section: Melanins and Melanin-like Materials In Tissue Engineeringmentioning

confidence: 99%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

View full text Add to dashboard Cite

Melanins are a group of dark insoluble pigments found widespread in nature. In mammals, the brown-black eumelanins and the reddish-yellow pheomelanins are the main determinants of skin, hair, and eye pigmentation and play a significant role in photoprotection as well as in many biological functions ensuring homeostasis. Due to their broad-spectrum light absorption, radical scavenging, electric conductivity, and paramagnetic behavior, eumelanins are widely studied in the biomedical field. The continuing advancements in the development of biomimetic design strategies offer novel opportunities toward specifically engineered multifunctional biomaterials for regenerative medicine. Melanin and melanin-like coatings have been shown to increase cell attachment and proliferation on different substrates and to promote and ameliorate skin, bone, and nerve defect healing in several in vivo models. Herein, the state of the art and future perspectives of melanins as promising bioinspired platforms for natural regeneration processes are highlighted and discussed.

show abstract

Section: Melanins and Melanin-like Materials In Tissue Engineeringmentioning

confidence: 99%

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The advanced healing strategies imply non-invasive monitoring of tissue recovery, pain management and controlled release of drugs accelerating regeneration and minimizing scar formation. 172 In regard to this, currently hydrogels prepared with various forms of NC are intensively studied including those which are sensitive to various external stimuli. Xu et al employed CNCs to improve the mechanical properties of thermo-responsive chitosan/glycerol phosphate sodium injectable hydrogels.…”

Section: Nc For Tissue Engineeringmentioning

confidence: 99%

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

et al. 2020

View full text Add to dashboard Cite

show abstract

“…When the skin barrier is disrupted through wounds, a series of complex physiochemical processes take place in an attempt to repair and regenerate the damaged tissue [4]. Wound healing is based on a complex series of cellular and biochemical processes, starting with inflammatory reactions (immune response to prevent infection), followed by proliferation (regeneration of tissues), and finalizing with tissue remodeling [5]. Based on the time that is required for wound healing, two types of wounds can be established: acute and chronic.…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

et al. 2020

View full text Add to dashboard Cite

Wound healing requires careful, directed, and effective therapies to prevent infections and accelerate tissue regeneration. In light of these demands, active biomolecules with antibacterial properties and/or healing capacities have been functionalized onto nanostructured polymeric dressings and their synergistic effect examined. In this work, various antibiotics, nanoparticles, and natural extract-derived products that were used in association with electrospun nanocomposites containing cellulose, cellulose acetate and different types of nanocellulose (cellulose nanocrystals, cellulose nanofibrils, and bacterial cellulose) have been reviewed. Renewable, natural-origin compounds are gaining more relevance each day as potential alternatives to synthetic materials, since the former undesirable footprints in biomedicine, the environment, and the ecosystems are reaching concerning levels. Therefore, cellulose and its derivatives have been the object of numerous biomedical studies, in which their biocompatibility, biodegradability, and, most importantly, sustainability and abundance, have been determinant. A complete overview of the recently produced cellulose-containing nanofibrous meshes for wound healing applications was provided. Moreover, the current challenges that are faced by cellulose acetate- and nanocellulose-containing wound dressing formulations, processed by electrospinning, were also enumerated.

show abstract

The production and application of hydrogels for wound management: A review

Cited by 225 publications

References 214 publications

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Melanin and Melanin-Like Hybrid Materials in Regenerative Medicine

Naturally derived nano- and micro-drug delivery vehicles: halloysite, vaterite and nanocellulose

Electrospun Nanocomposites Containing Cellulose and Its Derivatives Modified with Specialized Biomolecules for an Enhanced Wound Healing

Contact Info

Product

Resources

About