The Processing Space of the Spray-Dried Mannitol-Leucine System for Pulmonary Drug Delivery
Riley T. Schweizer,
Mani Ordoubadi,
Cody A. Prather
et al.
Abstract:Designing spray-dried particles for inhalation aims at specific physicochemical properties including a respirable aerodynamic diameter and adequate powder dispersibility. Leucine, an amphiphilic amino acid, has been shown to aid in optimizing bulk powder properties. Mannitol, a model crystalline active and common bulking agent, was co-sprayed with leucine at several excipient ratios, ethanol/water ratios, and spray dryer outlet temperatures in order to experimentally probe the underlying particle formation mec… Show more
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