The processes behind drug loading and release in porous drug delivery systems

Farzan, Maryam; Roth, Raphael; Schoelkopf, Joachim; Huwyler, Jörg

doi:10.1016/j.ejpb.2023.05.019

Cited by 20 publications

(8 citation statements)

References 173 publications

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“…Presumably, dense Chit/Gelatin film has a dense non‐porous structure, the loaded BSA is more distributed on the surface of the film thus led to such rapid release, while the microstructure of porous layer of the Janus Chit/Gelatin film impedes the release of the BSA by providing more surface area for BSA adsorption. [ 26 ] In many applications (e.g., controlled drug release), a slower, more sustained release is beneficial compared to a rapid burst pattern of release.…”

Section: Resultsmentioning

confidence: 99%

Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration

Lei,

Liao,

Wang

et al. 2024

Advanced Science

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Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition and microstructure. Here, it is reported that controlled, mild electronic inputs (<10 V; <20 min) induce a homogeneous gelatin‐chitosan mixture to undergo sorting and bottom‐up self‐assembly into a Janus film with compositional gradient (i.e., from chitosan‐enriched layer to chitosan/gelatin‐contained layer) and tunable dense‐porous gradient microstructures (e.g., porosity, pore size, and ratio of dense to porous layers). This Janus film performs is shown multiple functions for guided bone regeneration: the integration of compositional and microstructural features confers flexible mechanics, asymmetric properties for interfacial wettability, molecular transport (directional growth factor release), and cellular responses (prevents fibroblast infiltration but promotes osteoblast growth and differentiation). Overall, this work demonstrates the versatility of electrofabrication for the customized manufacturing of functional gradient soft matter.

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Section: Resultsmentioning

confidence: 99%

Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration

Lei,

Liao,

Wang

et al. 2024

Advanced Science

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“…Early work tuning melt blown fiber surface properties involved post-treatment steps such as hydrolysis of polyester nonwovens to produce nanoscale surface roughness and modify the surface chemistry. 1,12 Fibers can be further modified to enable anisotropic wetting 13 or allow loading of active materials 4,14 by incorporating oriented surface structures or internal porosity. These types of structures are almost exclusively produced using electrospinning with nonsolvent induced phase separation forming the pores.…”

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confidence: 99%

“…Incorporating surface roughness, chemical surface modification, or internal porosity into melt blown fibers can enable further refinement of properties for filtration and coalescence media or bring the high throughput and efficiency of melt blowing to higher value applications, including drug delivery and water remediation. Early work tuning melt blown fiber surface properties involved post-treatment steps such as hydrolysis of polyester nonwovens to produce nanoscale surface roughness and modify the surface chemistry. , Fibers can be further modified to enable anisotropic wetting or allow loading of active materials , by incorporating oriented surface structures or internal porosity. These types of structures are almost exclusively produced using electrospinning with nonsolvent induced phase separation forming the pores. − However, electrospinning often requires dissolution of the feed polymer in a solvent (often <20 wt % polymer), limiting the throughput and types of polymers compatible with the process .…”

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confidence: 99%

Porous Melt Blown Poly(butylene terephthalate) Fibers with High Ductility and High-Temperature Structural Stability

Goetze,

Benitez,

Bates

et al. 2024

ACS Macro Lett.

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In this study, porous poly(butylene terephthalate) (PBT) fibers were produced by melt blowing cocontinuous blends of PBT and polystyrene (PS) and selectively extracting the interconnected PS domains. Small amounts of hydroxyl terminated PS additives that can undergo transesterification with the ester units in PBT were added to stabilize the cocontinuous structure during melt processing. The resulting fibers are highly ductile and display fine porous structural features, which persist at temperatures over 150 °C. Single fiber tensile testing and electron microscopy are presented to demonstrate the role of rapid quenching and drawing of the melt blowing process in defining the fiber properties. The templated highly aligned pore structure, which is not easily produced in solvent-based fiber spinning methods, leads to remarkable mechanical properties of the porous fibers and overcomes the notoriously poor tensile properties common to other cellular materials like foams.

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“…Drug carrier systems might be able to sustain a continuous release of therapeutic agents by prolonging the kinetics of this breakdown. [42] This is crucial because metabolic processes could potentially reduce the effectiveness of this therapeutic approach. It also gives the medication enough time to take effect.…”

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confidence: 99%

PLA-HA/Fe3O4 magnetic nanoparticles loaded with Curcumin: Physicochemical characterization and toxicity evaluation in HCT116 Colorectal cancer cells

Bourang,

Asadian,

Noruzpour

et al. 2024

Preprint

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Colorectal cancer (CRC) is the third most common, harmful, and universal cancer and the second lethal type. This paper discusses the therapeutic potential of curcumin, a major curcuminoid found in the substructure of plant Curcuma longa (turmeric), against CRC. Curcumin has the ability to disrupt a variety of cellular signaling pathways and has been validated in several preclinical and clinical studies, but suffers from low solubility and bioavailability. To address these issues, PLA-HA/Fe3O4 magnetic nanoparticles were synthesized and loaded with curcumin. The average size and zeta potential of the nanoparticles and the magnetic properties were measured. The drug encapsulation efficiency and cumulative release of curcumin from the nanoparticles under acidic and neutral pH values were evaluated, as well as the cytotoxic effect of the nanoparticles on HCT116 colorectal cancer cells. The results demonstrated that nanoparticles have a high degree of biocompatibility and the ability to carry Curcumin medications. HCT116 cells with 200 µg/ml PLA-HA/Fe3O4/Curcumin nanoparticles have 58.63 ± 3.7% percent cell viability. Ultimately, PLA-HA, Fe3O4, and Curcumin's physicochemical characteristics and impact on cell viability render them valuable instruments for precisely delivering drugs to colorectal cancer cells. The PLA-HA/Fe3O4-curcumin nanoparticles demonstrated a well-targeted drug delivery system for upcoming colorectal cancer treatments, as evidenced by their overall strong cytotoxic effects on colorectal cancer cells and negligible toxicity towards non-cancerous cells.

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The processes behind drug loading and release in porous drug delivery systems

Cited by 20 publications

References 173 publications

Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration

Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration

Porous Melt Blown Poly(butylene terephthalate) Fibers with High Ductility and High-Temperature Structural Stability

PLA-HA/Fe3O4 magnetic nanoparticles loaded with Curcumin: Physicochemical characterization and toxicity evaluation in HCT116 Colorectal cancer cells

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