“…16 It is assumed that psychiatric patients are able to choose; act rationally, intentionally, and responsibly; and make decisions in terms of costs and benefits. 17 However, patients with severe mental illnesses such as schizophrenia, bipolar disorder, and major depression can go through phases in which their awareness of illness is impaired; this lack of insight, or anosognosia, represents the most significant reason for treatment refusal when they are acutely ill. 18 Therefore, adherence is a process that requires time for its proper development, where people suffering a psychiatric disorder need to identify as patients, develop awareness of their mental illness, participate in their mental health care, and establish a relationship of trust and collaboration with mental health professionals. Adherence to prescribed psychiatric medication in severe mental illness is a dynamic variable and there are major differences between in-and outpatient treatments.…”