The Problem of the Gonococcus Carrier

Carpenter, Charles M.; Westphal, Robert S.

doi:10.2105/ajph.30.5.537

Cited by 21 publications

(9 citation statements)

References 2 publications

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“…These findings confirm previous observations by Rosenthal (1972Rosenthal ( , 1975. One explanation of these results could be the presence of asymptomatic male and female carriers of gonococcal infection in the group of controls (Carpenter and Westphal, 1940;Pariser, 1972;Handsfield et al, 1974). In previous studies on the lymphocyte response to gonococcal antigen in patients with chronic Reiter's disease, Rosenthal (1972Rosenthal ( , 1973Rosenthal ( , 1976 observed that 41 % of the lymphocytes from controls gave an intensified cellular reaction in response to gonococcal antigen.…”

Section: Discussionmentioning

confidence: 94%

Lymphocyte reactivity in patients with gonococcal urethritis.

Rosenthal¹,

Sandström²

1978

Sexually Transmitted Infections

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SUMMARY Lymphocyte reactivity to virulent gonococcal antigen T2 and the non-pathogenic Neisseria pharyngis (NPN) has been studied by using the 14C-thymidine uptake in cell cultures from 42 patients with gonococcal urethritis and from 18 controls. The DNA synthesis in cell cultures with T2 antigen was higher in 21 female patients than in the 18 controls. No differences in DNA synthesis were observed in antigen-stimulated cell cultures from patients with single or multiple infections, from patients with urogenital complications, or from controls. Gonococcal antibodies in the serum were detected by the gonococcal complement-fixation test (GCFT). A study of the possible correlation between the outcome of the serological test and the cellular response to gonococcal antigen showed that 14C-thymidine uptake in lymphocyte cultures from male patients with negative GCFT, stimulated with T2 antigen, was much lower than the thymidine uptake in stimulated cell cultures from all the other male and female patients (P<0 001). The DNA synthesis was higher in cell cultures from seronegative women than from seronegative men (P<00 1). A significant difference (P<001) was also noted in the lymphocyte reactivity to gonococcal antigen between controls and all patients, except in those men who gave negative results to the serological tests. There were no differences between these two groups with respect to the thymidine uptake in NPN-stimulated cell cultures.

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Section: Discussionmentioning

confidence: 94%

Lymphocyte reactivity in patients with gonococcal urethritis.

Rosenthal¹,

Sandström²

1978

Sexually Transmitted Infections

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“…This has also been pointed out by Carpenter in a recent article. 5 Previous to the use of cultures the chief criterion of cure in the male adult has been the examination of smears obtained after prostate massage. An arbitrary standard of 5 consecutive such prostate smears was necessary before a patient would be discharged as ."…”

Section: Vol 31mentioning

confidence: 99%

“…Several factors may be blamed in this 17.6 per cent of failure of cultural growth in these 27 cases (17.6 per cent of the total). First it might be stated that in most cases only one culture per patient was made, whereas 5 or more smears were made on each patient up for discharge. Again, inasmuch as these smears and the culture were made from material obtained after prostate massage, often there was not enough material available for both procedures.…”

Section: Vol 31mentioning

confidence: 99%

Use of the Culture Method in the Clinical Management of Gonorrhea

Sewell¹,

Clarke²,

Nelson³

1941

Am J Public Health Nations Health

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“…Data sampled in highly selected groups like these may, however, induce wrong conclusions [9]. For this rea son, it has been extremely useful for our knowledge of the distribution of gonococci that Carpenter and West pliai [4] investigated a population not Fiumara et al [7] 1969 proof of the presence of N. gonorrhoeae in the throat of 1 out of 505 asymptomatic soldiers ex amined…”

Section: Introductionmentioning

confidence: 99%

Gonococcal Carriage in the Throat – No Common Findings Anyhow?

Hc¹

1981

Dermatology

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Urethral carriage of gonococci is now accepted as a common phenomenon. During the last 10 years, moreover, gonococcal infections of the throat – both symptomatic and asymptomatic – have increasingly been demonstrated. As most investigations were undertaken in a highly selected population (VD patients), it seemed useful to screen a group of army recruits for the presence of Neisseria gonorrhoeae in their throats. In fact, while Neisseria meningitidis turned up very often, no such strains could be found. So gonococcal pharyngeal – other than urethral – carriage cannot be considered as a normal finding in an unselected population; as high as the corresponding rates in VD patients may be.

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The Problem of the Gonococcus Carrier

Cited by 21 publications

References 2 publications

Lymphocyte reactivity in patients with gonococcal urethritis.

Lymphocyte reactivity in patients with gonococcal urethritis.

Use of the Culture Method in the Clinical Management of Gonorrhea

Gonococcal Carriage in the Throat – No Common Findings Anyhow?

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