The study of sex distribution revealed an increase of the percentage of females among more than 12 000 patients with pyelonephritis, renal tuberculosis and nephroureterolithiasis in the period 1959-73 from 69 to 75%, from 63 to 69% and from 54 to 64%, respectively. The tendency revealed may be explained by a decrease of the role of general causal factors, which are of the same importance for males and females, and by the relative increase of the role of local factors, which are of greater importance for females due to pregnancy, delivery, and gynecological disorders. The role of the latter factors in the pathogenesis of infectious and calculous renal diseases in women is confirmed by the study of the history and the fate of female patients and by a more frequent affection of their right kidney. Women after complicated pregnancy and delivery, gynecological diseases and genital surgery need regulat dispensary urological observation to prevent and detect early infectious and calculous renal diseases.