Pion exchange is the central ingredient to nucleon-nucleon interactions used in nuclear structure calculations, and one pion exchange (OPE) enters at leading order in chiral effective field theory. In the 2S+1 LJ = 1 S0 partial wave, however, OPE and a contact term needed for proper renormalization fail to produce the qualitative, and quantitative, features of the scattering phase shifts. Cutoff variation also revealed a surprisingly low breakdown momentum Λ b ≈ 330 MeV in this partial wave.Here we show that potentials consisting of OPE, two pion exchange (TPE), and a single contact address these problems and yield accurate and renormalization group (RG) invariant phase shifts in the 1 S0 partial wave. We demonstrate that a leading-order potential with TPE can be systematically improved by adding a contact quadratic in momenta. For momentum cutoffs Λ 500 MeV, the removal of relevant physics from TPE loops needs to be compensated by additional contacts to keep RG invariance. Inclusion of the ∆ isobar degree of freedom in the potential does not change the strong contributions of TPE.