THE PROBLEM OF PLACENTAL PERMEABILITY FOR THYROTROPHIN, PROPYLTHIOURACIL AND THYROXINE IN THE GUINEA PIG<sup>1</sup>

Peterson, Roy R.; Young, William C.

doi:10.1210/endo-50-2-218

Cited by 74 publications

(10 citation statements)

References 9 publications

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“…The observations of Peterson & Young (1952), showing that thyroxine crosses from the mother to the foetus in guinea-pigs, do not necessarily conflict with the conclusions reached here. In their experiments, thyroxine, given to the mother continuously during the last 30 days of pregnancy, was shown to prevent the formation of thiouracil-induced goitres in foetuses delivered at full term.…”

Section: Discussionsupporting

confidence: 49%

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

Hall¹,

Myant²

1956

The Journal of Physiology

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Section: Discussionsupporting

confidence: 49%

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

Hall¹,

Myant²

1956

The Journal of Physiology

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“…There was, however, evidence that the ma¬ terial was not readily removed from the site of injection, and oral treatment of the mothers with w-propylthiouracil, which is known to penetrate the placenta (Peterson and Young, 1952) and to be secreted in the milk (Fazekas and others, 1951), was there¬ fore undertaken. The animals reared by mothers treated with M-propylthiouracil showed retardation of the lesion varying in degree and merging into the normal range.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Nutritional and Endocrine Factors on an Inherited Retinal Degeneration in the Mouse

Lucas¹,

Newhouse²

1957

Archives of Ophthalmology

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“…21 grossly normal human fetuses were obtained immediately after therapeutic abortion. Blood was drawn by cardiac puncture and/or cord exsanguination.…”

Section: Methodsmentioning

confidence: 99%

Observations on the maturation of thyroid function in early fetal life

Greenberg¹,

Czernichow²,

Reba³

et al. 1970

J. Clin. Invest.

118

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ABSTRA CT Serum samples were obtained from 21 normal human fetuses after therapeutic abortion for psychiatric indications. Fetal crown-rump length ranged from 5.2 to 22.5 cm, corresponding to the gestational age of 65-168 days.Serum thyroxine, assayed by a modification of the Murphy-Pattee method, was identified in the second' smallest fetus examined at 78 days gestation. Thereafter it increased rapidly, maintaining a significant linear correlation with crown-rump length until term (r = 0.800, P < 0.001). Free thyroxine (FT4) also increased in a linear relation to gestational age (r = 0.908, P < 0.001), but reached term levels by 18-20 wk. Radioimmunoassayable thyroid-stimulating hormone (TSH) was detected at 78 days gestation. Levels increased rapidly with advancing gestation, so that by 16 wk almost all were within the range of term infants. After 16 wk gestation, levels were usually greater than 4.0 MU/cc, higher than that seen in normal children.No correlation was demonstrated between the serum TSH levels and total thyroxine. TSH and FT4, however, increased in a parallel manner with a significant positive correlation. This suggested that fetal TSH secretion was responsive to FT4 levels from very early in gestation, possibly as early as 11 wk.Thyroxine-binding globulin (TBG) was detected in a fetus of 78 days gestation (1.4 Ag/100 ml). Levels increased rapidly, paralleling the rise in serum thyroxine and maintaining a linear correlation with crownrump length (r = 0.864, P < 0.001). Thyroxine-binding prealbumin binding capacity (TBPA) in fetuses 14-24 wk gestation was comparable with that seen at term.When examining the distribution of tracer amounts of thyroxine-"31I (T4-"'I) between the thyroxine-binding

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THE PROBLEM OF PLACENTAL PERMEABILITY FOR THYROTROPHIN, PROPYLTHIOURACIL AND THYROXINE IN THE GUINEA PIG¹

Cited by 74 publications

References 9 publications

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

The Effects of Nutritional and Endocrine Factors on an Inherited Retinal Degeneration in the Mouse

Observations on the maturation of thyroid function in early fetal life

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THE PROBLEM OF PLACENTAL PERMEABILITY FOR THYROTROPHIN, PROPYLTHIOURACIL AND THYROXINE IN THE GUINEA PIG1

Cited by 74 publications

References 9 publications

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

Passage of exogenous thyroxine and of iodide between mother and foetus in pregnant rabbits

The Effects of Nutritional and Endocrine Factors on an Inherited Retinal Degeneration in the Mouse

Observations on the maturation of thyroid function in early fetal life

Contact Info

Product

Resources

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THE PROBLEM OF PLACENTAL PERMEABILITY FOR THYROTROPHIN, PROPYLTHIOURACIL AND THYROXINE IN THE GUINEA PIG¹