The Problem of Neuronal Syncytical Connection in Disease

Abstract

The membranes of neuron profiles adjacent to each other in the caudal mesenteric ganglion were examined electron microscopically during the first 3 days after crossing of the preganglionar or postganglionar branches. The contacting membranes were thinned and perforated, and neuron-to-neuron syncytial connections were forming. Multiple connections were formed between the nerve processes and terminals in the synapse. The pre- and even postsynapses were clear in pronounced perforations.

Interneuronal Membrane Contacts and Syncytial Perforations in CA2 Hippocampal Area after Brain Trauma

“…Numerous modern investigations make a point of interneuronal and glial-neuronal contacts developing in various areas of the central and peripheral nervous system after changes in the physiological state, exposure to extreme factors, or during various pathologies [6,8]. Lability of theses connections appears to be a fi ne instrument of neuronal plasticity.…”

“…Syncytial connections were found in brain hypoxia [7] and in intact brain [15]. They were also described in autonomic ganglia in Wallerian degeneration [8].…”