The Probable Systemic Nature of Mikulicz's Disease and Its Relation to Sjögren's Syndrome

Morgan, Winfield S.

doi:10.1056/nejm195407012510102

Cited by 167 publications

(43 citation statements)

References 25 publications

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“…This is one of the 2 classical tests for the dry eye and for most clinicians is often the crucial test which decides future management. Shapiro and Merin,21 using a modified method, found the mean value for 880 healthy eyes of volunteer students to be 33-1 mm in 5 minutes with a standard deviation of 33 2! (our exclamation mark).…”

Section: Assessment Of the Eye For Drynessmentioning

confidence: 99%

The questionably dry eye.

Mackie¹,

Seal²

1981

British Journal of Ophthalmology

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From 1Moorfields Eye Hospital, City Road, London EC], and the 2Public Health Laboratory, General Hospital, Tremona Road, Southampton S09 4XY SUMMARY This paper is concerned with the recognition of the dry eye when the clinical diagnosis is in doubt and other external eye diseases may be present. Papillary conjunctivitis is common to the dry eye as well as other pathological conditions and confuses the diagnosis. We have correlated the factors involved in the assessment for dryness. We have shown that particulate matter in the unstained tear film is associated with low tear lysozyme concentration. Tear flow and tear lysozyme are not necessarily interrelated, but a low lysozyme concentration (tear lysozyme ratio <1 0) is associated with keratoconjunctivitis sicca. The Schirmer I test can produce false positive results, and we have suggested a modification to overcome this. This modified test will detect the eye with severely depleted lysozyme secretion, but it is unreliable for detecting the eye with moderately depleted secretion. We find that its lowest normal limit should be considered as 6 mm.

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Section: Assessment Of the Eye For Drynessmentioning

confidence: 99%

The questionably dry eye.

Mackie¹,

Seal²

1981

British Journal of Ophthalmology

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“…Многие авторы описывают IgG4-ассоциированные сиалоадениты и дакриоадениты, не имеющие генерализо-ванного характера поражения, иногда с наличием фиброза, называя их БМ. По их критериям, для постановки диагно-за БМ необходимо иметь стойкое увеличение как минимум двух больших слюнных или слезных желез, повышение уровня IgG4 и отсутствие таких заболеваний, как БШ, лимфома, саркоидоз и т. д. Такие формы не следует класси-фицировать как БМ, они должны быть выделены в отдель-ную группу IgG4-связанных поражений слюнных и слез-ных желез [35,64,65,[67][68][69][70][71][72].…”

Section: поражение слюнных желез и орбит при Igg4-связан-ных системныunclassified

“…П р о г р е с с р е в м а т о л о г и и в X X I в е к е Науч-практич ревматол 2012; 54(5): [64][65][66][67][68][69][70][71][72] …”

Section: заключениеunclassified

IgG4-LINKED SYSTEMIC DISEASE. MODERN OUTLOOK ON «OLD» DISEASE

Седышев¹,

Vasiliev²,

Kovriguina³

et al. 2012

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“…Schaffer and Jacobsen (2) linked the case to obvious diseases, such as sarcoidosis and lymphoma, presenting these symptoms as Mikulicz's syndrome and idiopathic cases as Mikulicz's disease (MD) in 1927. Morgan and Castleman examined the specimens from 18 cases diagnosed with MD and proposed that MD is a subtype of Sjögren's symdrome (SS) in 1953 (3). However, MD represents a unique condition involving enlargement of the lachrymal and salivary glands and good responsiveness to glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

A Case of Mikulicz's Disease, IgG4-related Plasmacytic Syndrome, Successfully Treated by Corticosteroid and Mizoribine, Followed by Mizoribine Alone

et al. 2010

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We report a case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated with corticosteroid and mizoribine, followed by mizoribine alone. A 56-year-old woman experienced persistent bilateral swelling in the eyelids and submandibular region accompanied by lymphadenopathy without pain. The patient was diagnosed as having Mikulicz's disease since her bilateral lacrimal glands showed persistent swelling and biopsy specimens of the submandibular glands and lymph node showed diffuse infiltration of lymphocytes and plasma cells. Symptoms and laboratory data were improved with corticosteroids (30 mg). However, after tapering prednisolone to 5 mg, submandibular swelling developed. Adding mizoribine resulted in clinical improvement. Prednisolone was tapered and finally discontinued. Since the levels of IgG4 in peripheral blood were increased even after corticosteroid therapy and IgG4 was positive in a submandibular gland specimen obtained before the start of corticoid therapy. Thus, this case may be associated with IgG4. The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome.

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The Probable Systemic Nature of Mikulicz's Disease and Its Relation to Sjögren's Syndrome

Cited by 167 publications

References 25 publications

The questionably dry eye.

The questionably dry eye.

IgG4-LINKED SYSTEMIC DISEASE. MODERN OUTLOOK ON «OLD» DISEASE

A Case of Mikulicz's Disease, IgG4-related Plasmacytic Syndrome, Successfully Treated by Corticosteroid and Mizoribine, Followed by Mizoribine Alone

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