The Probable, Possible, and Novel Functions of ERp29

Brecker, Margaret; Khakhina, Svetlana; Schubert, Tyler J; Thompson, Zachary; Rubenstein, Ronald C.

doi:10.3389/fphys.2020.574339

Cited by 23 publications

(13 citation statements)

References 133 publications

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“…Since ZHX2 is also associated with cortical neuronogenesis [ 42 ], it may be associated with the progression to dementia. ERP29 gene encodes a 29 kDa endoplasmic reticulum protein (ERp29), which is ubiquitously expressed in cells and regulates protein transport between the endoplasmic reticulum and Golgi apparatus [ 44 ]. ERp29 is involved in protein misfolding and mistrafficking [ 44 , 45 ], which are potent pathogenic features of PD and Alzheimer’s disease [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…ERP29 gene encodes a 29 kDa endoplasmic reticulum protein (ERp29), which is ubiquitously expressed in cells and regulates protein transport between the endoplasmic reticulum and Golgi apparatus [ 44 ]. ERp29 is involved in protein misfolding and mistrafficking [ 44 , 45 ], which are potent pathogenic features of PD and Alzheimer’s disease [ 46 ]. Given that endoplasmic reticulum stress is related to Lewy body dementia [ 47 ], it is possible that ERp29 mutation also induces cortical neuronal damage and is linked to the progression of dementia in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

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Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson’s Disease

Park

Hwang

et al. 2021

Genes

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Dementia is one of the most disabling nonmotor symptoms of Parkinson’s disease (PD). However, the risk factors contributing to its development remain unclear. To investigate genetic variants associated with dementia in PD, we performed microarray genotyping based on a customized platform utilizing variants identified in previous genetic studies. Microarray genotyping was performed in 313 PD patients with dementia, 321 PD patients without dementia, and 635 healthy controls. The primary analysis was performed using a multiple logistic regression model adjusted for age and sex. SNCA single nucleotide polymorphism (SNP) rs11931074 was determined to be most significantly associated with PD (odds ratio = 0.66, 95% confidence interval = 0.56–0.78, p = 7.75 × 10−7). In the analysis performed for patients with PD only, MUL1 SNP rs3738128 (odds ratio = 2.52, 95% confidence interval = 1.68–3.79, p = 8.75 × 10−6) was found to be most significantly associated with dementia in PD. SNPs in ZHX2 and ERP29 were also associated with dementia in PD. This microarray genomic study identified new loci of MUL1 associated with dementia in PD, suggesting an essential role of mitochondrial dysfunction in the development of dementia in patients with PD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson’s Disease

Park

Hwang

et al. 2021

Genes

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“…Endoplasmic reticulum (ER) protein 29 (ERp29) is highly expressed throughout mammalian tissues. It predominantly acts as an ER to Golgi escort/chaperone proteins [ 103 , 104 , 105 , 106 ]. Cancer research revealed additional properties of ERp29, including cell growth arrest and involvement in MET.…”

Section: The Metastatic Cells Journey To the Brainmentioning

confidence: 99%

The Journey of Cancer Cells to the Brain: Challenges and Opportunities

Łazarczyk

Mickael

Skiba

et al. 2023

IJMS

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Cancer metastases into the brain constitute one of the most severe, but not uncommon, manifestations of cancer progression. Several factors control how cancer cells interact with the brain to establish metastasis. These factors include mediators of signaling pathways participating in migration, infiltration of the blood–brain barrier, interaction with host cells (e.g., neurons, astrocytes), and the immune system. Development of novel therapies offers a glimpse of hope for increasing the diminutive life expectancy currently forecasted for patients suffering from brain metastasis. However, applying these treatment strategies has not been sufficiently effective. Therefore, there is a need for a better understanding of the metastasis process to uncover novel therapeutic targets. In this review, we follow the journey of various cancer cells from their primary location through the diverse processes that they undergo to colonize the brain. These processes include EMT, intravasation, extravasation, and infiltration of the blood–brain barrier, ending up with colonization and angiogenesis. In each phase, we focus on the pathways engaging molecules that potentially could be drug target candidates.

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“…Günümüze kadar memeli hücrelerinde UPR yolağının uyarılmasından, ER lümenindeki katlanmamış proteinler tarafından aktive edilen, ER zarına yerleşik üç sinyal molekülü keşfedilmiştir: İnositol gerektiren kinaz 1 (IRE1), aktive edici transkripsiyon faktörü 6 (ATF6) ve protein kinaz RNA benzeri ER kinaz (PERK)(Şekil 3) 28,29 . Bu üç sinyal molekülünün odakta olduğu UPR yolaklarıyla katlanmamış ya da hatalı katlanan proteinlere karşı hücre homeostazı düzenlenmektedir.…”

Section: Granüllü Endoplazmik Retikulumda Proteinlerin Kalite Kontrol...unclassified

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

Sel

Oguz

2022

Arşiv Kaynak Tarama Dergisi

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The endoplasmic reticulum (ER) is the first compartment of the secretory pathway and is a bilayer membranous intracellular organelle found in almost all cells except highly specialized eukaryotic cells such as erythrocytes and sperm cells. The ER is involved in many different cellular functions. ER contributes to the production and folding of approximately one-third of cellular proteins, and plays an important role for the maintenance of cellular homeostasis. In addition to, it acts as a protein synthesis factory, contributes to the storage and regulation of calcium, to the synthesis and storage of lipids, and glucose metabolism. Besides these features, specific ER stress signaling pathways, known as the 'unfolded protein response', are required for maintaining ER homeostasis. ER homeostasis can be given cause for many pathological events, including protein misfolding or accumulation of mutant protein, which can lead to ER stress. In this review, unfolded protein response of the endoplasmic reticulum and diseases associated with unfolded protein response are discussed.

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The Probable, Possible, and Novel Functions of ERp29

Cited by 23 publications

References 133 publications

Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson’s Disease

Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson’s Disease

The Journey of Cancer Cells to the Brain: Challenges and Opportunities

Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar

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