The proangiogenic role of polymorphonuclear myeloid-derived suppressor cells in mice infected with &lt;i&gt;Echinococcus granulosus &lt;/i&gt;

Yin, Jiong; Shen, Yujuan; Yu, Aiping; Liu, Congshan; Yao, Jiaqing; Gong, Weiming; Cao, Jianping

doi:10.5582/bst.2018.01105

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…A study found that MDSCs may interact with lysosomal acid lipase to cause dysfunction of ECs (16). Moreover, in vitro experiments have shown that the culture supernatant of PMN-MDSCs can significantly promote the tube formation of HUVECs (143). This finding indicates that PMN-MDSCs may secrete some pro-angiogenic factors.…”

Section: Myeloid-derived Suppressor Cellsmentioning

confidence: 98%

A New Antitumor Direction: Tumor-Specific Endothelial Cells

et al. 2021

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Targeting tumor blood vessels is an important strategy for tumor therapies. At present, antiangiogenic drugs are known to have significant clinical effects, but severe drug resistance and side effects also occur. Therefore, new specific targets for tumor and new treatment methods must be developed. Tumor-specific endothelial cells (TECs) are the main targets of antiangiogenic therapy. This review summarizes the differences between TECs and normal endothelial cells, assesses the heterogeneity of TECs, compares tumorigenesis and development between TECs and normal endothelial cells, and explains the interaction between TECs and the tumor microenvironment. A full and in-depth understanding of TECs may provide new insights for specific antitumor angiogenesis therapies.

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Section: Myeloid-derived Suppressor Cellsmentioning

confidence: 98%

A New Antitumor Direction: Tumor-Specific Endothelial Cells

et al. 2021

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“…The persistent infection of E. granulosus can span many years due to its evasion strategies. The interaction network between immune and immunosuppressive cells can increase the immune microenvironment complexity at the lesion site during infection ( 6 , 7 ). Angiogenesis contributes to hydatid cyst growth, and endothelial cells are key in tissue angiogenesis ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

The single-cell landscape of cystic echinococcosis in different stages provided insights into endothelial and immune cell heterogeneity

et al. 2022

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IntroductionHydatid cysts and angiogenesis are the key characteristics of cystic echinococcosis, with immune cells and endothelial cells mediating essential roles in disease progression. Recent single-cell analysis studies demonstrated immune cell infiltration after Echinococcus granulosus infection, highlighting the diagnostic and therapeutic potential of targeting certain cell types in the lesion microenvironment. However, more detailed immune mechanisms during different periods of E. granulosus infection were not elucidated.MethodsHerein, we characterized immune and endothelial cells from the liver samples of mice in different stages by single-cell RNA sequencing.ResultsWe profiled the transcriptomes of 45,199 cells from the liver samples of mice at 1, 3, and 6 months after infection (two replicates) and uninfected wild-type mice. The cells were categorized into 26 clusters with four distinct cell types: natural killer (NK)/T cells, B cells, myeloid cells, and endothelial cells. An SPP1+ macrophage subset with immunosuppressive and pro-angiogenic functions was identified in the late infection stage. Single-cell regulatory network inference and clustering (SCENIC) analysis suggested that Cebpe, Runx3, and Rora were the key regulators of the SPP1+ macrophages. Cell communication analysis revealed that the SPP1+ macrophages interacted with endothelial cells and had pro-angiogenic functions. There was an obvious communicative relationship between SPP1+ macrophages and endothelial cells via Vegfa–Vegfr1/Vegfr2, and SPP1+ macrophages interacted with other immune cells via specific ligand–receptor pairs, which might have contributed to their immunosuppressive function.DiscussionOur comprehensive exploration of the cystic echinococcosis ecosystem and the first discovery of SPP1+ macrophages with infection period specificity provide deeper insights into angiogenesis and the immune evasion mechanisms associated with later stages of infection.

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“…Each group has a different biological function and different mechanism involved in its mediation function [ 15 , 16 ]. In addition to tumors, recent studies have shown that some parasites (such as trypanosoma, nematodes and echinococcus) infection can induce the production of MDSCs, and MDSCs plays an important role in the occurrence and development of these parasitic diseases [ 21 – 23 ]. Our previous study found a large number of MDSCs aggregations in the spleen and lymph nodes of mice infected with S .…”

Section: Introductionmentioning

confidence: 99%

TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum

Zhou

Zhu²,

Mo³

et al. 2022

PLoS Negl Trop Dis

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Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune responses against Schistosoma japonicum (S. japonicum) infection. However, the role of Toll-like receptor 7 (TLR7) in the mouse lung during S. japonicum infection and the myeloid-derived suppressor cells (MDSCs) affected by the absence of TLR7 are not clearly understood. In this study, the results indicated that the MDSCs were accumulated and the proportion and activation of CD4+ and CD8+ T cells were decreased in the lung of mice at 6–7 weeks after S. japonicum infection. Then, the expression of TLR7 was detected in isolated pulmonary MDSCs and the results showed that the expression of TLR7 in MDSCs was increased after infection. Furthermore, TLR7 agonist R848 could down-regulate the induction effect of the soluble egg antigen (SEA) on pulmonary MDSCs in vitro. Meanwhile, TLR7 deficiency could promote the pulmonary MDSCs expansion and function by up-regulating the expression of PD-L1/2 and secreting of IL-10 in the mice infected with S. japonicum. Mechanistic studies revealed that S. japonicum infection and the antigen effects are mediated by NF-κB signaling. Moreover, TLR7 deficiency aggravates S. japonicum infection-induced damage in the lung, with more inflammatory cells infiltration, interstitial dilatation and granuloma in the tissue. In summary, this study indicated that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.

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The proangiogenic role of polymorphonuclear myeloid-derived suppressor cells in mice infected with <i>Echinococcus granulosus </i>

Cited by 4 publications

References 17 publications

A New Antitumor Direction: Tumor-Specific Endothelial Cells

A New Antitumor Direction: Tumor-Specific Endothelial Cells

The single-cell landscape of cystic echinococcosis in different stages provided insights into endothelial and immune cell heterogeneity

TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum

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