The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

Coffelt, Seth B.; Marini, Frank C.; Watson, Keri L.; Zwezdaryk, Kevin J.; Dembinski, Jennifer L.; LaMarca, Heather L.; Tomchuck, Suzanne L.; Bentrup, Kerstin Höner zu; Danka, Elizabeth S.; Henkle, Sarah L.; Scandurro, Aline B.

doi:10.1073/pnas.0900244106

Cited by 260 publications

(252 citation statements)

References 39 publications

Supporting

Mentioning

230

Contrasting

Unclassified

Order By: Relevance

“…The antimicrobial peptide LL-37, which is a ligand of the FPR1 variant FPRL1 (FPR2), was capable of stimulating the growth of epithelial tumor cells as well as recruiting mesenchymal stem cells into tumors to facilitate angiogenesis. [22][23][24] Our study revealed that knocking down either Anx A1 or its receptor FPR1 reduced the tumorigenicity of U87 GBM cells. Double knocking down FPR1/Anx A1 in U87 GBM cells further reduced their capacity to form actively growing tumors.…”

Section: Discussionmentioning

confidence: 90%

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

Yang

Liu

Yao

et al. 2011

The American Journal of Pathology

View full text Add to dashboard Cite

Highly malignant human gliomas overexpress the Gprotein-coupled chemoattractant receptor formyl peptide receptor (FPR1), which promotes tumor progression when activated. Our previous studies demonstrated that necrotic glioblastoma cells release chemotactic agonist(s) that activate FPR1 on viable tumor cells. In the present study, we identified an FPR1 agonist released by necrotic human glioblastoma cells.

show abstract

Section: Discussionmentioning

confidence: 90%

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

Yang

Liu

Yao

et al. 2011

The American Journal of Pathology

View full text Add to dashboard Cite

show abstract

“…Interestingly, Coffelt and colleagues have showed that this recruitment may be partly stimulated by LL-37 (leucine, leucine-37), which is a proinflammatory peptide of human cationic antimicrobial protein 18, in addition to other migratory signals (53). In an EOC xenograft model, human bone marrow-derived MSCs differentiated into CAFs, which was confirmed by the elevation of markers specific to fibroblast activation (54).…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Revisiting the Complexity of the Ovarian Cancer Microenvironment—Clinical Implications for Treatment Strategies

Musrap

Diamandis

2012

Molecular Cancer Research

View full text Add to dashboard Cite

Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies in North American women. Given that EOC encompasses a broad class of tumors consisting of a variety of different histologic and molecular subtypes, which generates genetically and etiologically distinct tumors, several challenges arise during treatment of patients with this disease. Overlaying this complexity is the contribution of supporting cells, particularly stromal components such as fibroblasts and immune infiltrates that collectively create a microenvironment that promotes and enhances cancer progression. A notable example is the induction of angiogenesis, which occurs through the secretion of pro-angiogenic factors by both tumor and tumor-associated cells. The recent development of angiogenic inhibitors targeting tumor vasculature, which have been shown to improve patient outcome when combined with standard therapy, has launched a paradigm shift on how cancer patients should be treated. It is evident that future clinical practices will focus on the incorporation of therapies that antagonize the protumoral effects of such microenvironment contributors. Herein, an overview of the varying tumor-host interactions that influence tumor behavior will be discussed, in addition to the recent efforts undertaken to target these interactions and their potential to revolutionize EOC patient care.

show abstract

“…Recent studies have shown that MSCs contribute to the growth of breast and ovarian cancer (25,26). The specific mechanisms by which this occurs have not yet been elucidated.…”

Section: Acceleration Of the Growth Of Colon Cancer In Mice By Mscs Pmentioning

confidence: 99%

Effects of Inflammatory Factors on Mesenchymal Stem Cells and Their Role in the Promotion of Tumor Angiogenesis in Colon Cancer

Liu

Han

Zhang

et al. 2011

Journal of Biological Chemistry

168

124

View full text Add to dashboard Cite

The pro-inflammatory peptide LL-37 promotes ovarian tumor progression through recruitment of multipotent mesenchymal stromal cells

Cited by 260 publications

References 39 publications

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

Annexin 1 Released by Necrotic Human Glioblastoma Cells Stimulates Tumor Cell Growth through the Formyl Peptide Receptor 1

Revisiting the Complexity of the Ovarian Cancer Microenvironment—Clinical Implications for Treatment Strategies

Effects of Inflammatory Factors on Mesenchymal Stem Cells and Their Role in the Promotion of Tumor Angiogenesis in Colon Cancer

Contact Info

Product

Resources

About