2016
DOI: 10.1016/j.exphem.2016.06.066
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The PRO-inflammatory cytokine interleukin-1 is a key regulator of hematopoietic Stem cell fate and function

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Cited by 6 publications
(7 citation statements)
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“…Indeed, it has been observed that administration of IL-1 prior lethal doses of radiation protects mice from fatal hematopoietic syndrome (113), which is associated to the role of IL-1 on cell cycle activation through the expansion of HSPCs and myeloid precursor cells (114)(115)(116). Moreover, chronic IL-1 exposure leads to impairment of HSCs function (117). However, the mechanisms leading to these effects are still largely unknown.…”
Section: Interleukin-1 and -6 And Their Role In Hematopoiesismentioning
confidence: 99%
“…Indeed, it has been observed that administration of IL-1 prior lethal doses of radiation protects mice from fatal hematopoietic syndrome (113), which is associated to the role of IL-1 on cell cycle activation through the expansion of HSPCs and myeloid precursor cells (114)(115)(116). Moreover, chronic IL-1 exposure leads to impairment of HSCs function (117). However, the mechanisms leading to these effects are still largely unknown.…”
Section: Interleukin-1 and -6 And Their Role In Hematopoiesismentioning
confidence: 99%
“…For example, macrophage (M)-CSF deficiency reduced atherosclerotic lesion size in both diet-induced hypercholesteremia and Apoe -/atherosclerotic mouse models (26,27). In addition to atherosclerosis, following a myocardial infarction, sympathetic activity initiates extramedullary haematopoiesis via the canonical inflammatory cytokine interleukin (IL)-1β, which drives HSCs toward myelopoiesis (35)(36)(37). Finally, we have recently shown that…”
Section: Cytokines Influence Myeloid Cells To Proliferate and Differementioning
confidence: 99%
“…1,2 Several cytokines, including interferon alpha (IFNa), interferon gamma (IFNg) and interleukin-1beta (IL1b) all have been shown to drive quiescent hematopoietic stem cells (HSCs) into cycle and alter hematopoietic output. [3][4][5][6] Acute exposure to type I interferons (IFN-1), which includes IFNa and interferon beta (IFNb), promotes HSC proliferation and emergency megakaryopoiesis. 3,7 Likewise, IL1b exposure induces transient HSC proliferation and myelopoiesis.…”
Section: Introductionmentioning
confidence: 99%
“…3,7 Likewise, IL1b exposure induces transient HSC proliferation and myelopoiesis. 5,8 These changes enhance blood production and immune function under conditions of stress. Inflammatory cytokines also help maintain basal hematopoietic output.…”
Section: Introductionmentioning
confidence: 99%