The pro-healing effects of medical grade honey supported by a pediatric case series

Smaropoulos, Eleftherios; Cremers, Niels A. J.

doi:10.1016/j.ctim.2019.05.014

Cited by 17 publications

(26 citation statements)

References 28 publications

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“…MGH is strictly controlled and extensively tested honey, guaranteeing its safety and efficacy for medical purposes [19]. MGH exerts both broad-spectrum antimicrobial activity and wound-healing-promoting properties [20][21][22][23]. The main antimicrobial activities of MGH are thought to rely on the low pH, osmotic activity, production of hydrogen peroxide, and the presence of antimicrobial molecules (e.g., phytochemicals such as flavonoids).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication

et al. 2020

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Biofilms hinder wound healing. Medical-grade honey (MGH) is a promising therapy because of its broad-spectrum antimicrobial activity and the lack of risk for resistance. This study investigated the inhibitory and eradicative activity against multidrug-resistant Pseudomonas aeruginosa biofilms by different established MGH-based wound care formulations. Six different natural wound care products (Medihoney, Revamil, Mebo, Melladerm, L-Mesitran Ointment, and L-Mesitran Soft) were tested in vitro. Most of them contain MGH only, whereas some were supplemented. L-Mesitran Soft demonstrated the most potent antimicrobial activity (6.08-log inhibition and 3.18-log eradication). Other formulations ranged between 0.89-log and 4.80-log inhibition and 0.65-log and 1.66-log eradication. Therefore, the contribution of different ingredients of L-Mesitran Soft was investigated in more detail. The activity of the same batch of raw MGH (1.38-log inhibition and 2.35-log eradication), vitamins C and E (0.95-log inhibition and 0.94-log eradication), and all ingredients except MGH (1.69-log inhibition and 0.75-log eradication) clearly support a synergistic activity of components within the L-Mesitran Soft formulation. Several presented clinical cases illustrate its clinical antimicrobial efficacy against Pseudomonas aeruginosa biofilms. In conclusion, MGH is a potent treatment for Pseudomonas biofilms. L-Mesitran Soft has the strongest antimicrobial activity, which is likely due to the synergistic activity mediated by its supplements.

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Section: Introductionmentioning

confidence: 99%

Synergistic Antimicrobial Activity of Supplemented Medical-Grade Honey against Pseudomonas aeruginosa Biofilm Formation and Eradication

et al. 2020

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“…The application of MGH to a wound can prevent infection and invasion of pathogens by forming a physical shield . Additionally, MGH possesses multiple characteristics that orchestrate its antimicrobial activity, and therefore also has a limited risk for the development of antimicrobial resistance .…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, MGH possesses multiple characteristics that orchestrate its antimicrobial activity, and therefore also has a limited risk for the development of antimicrobial resistance . The acidic pH, the osmotic effect caused by the high sugar content, and the release of hydrogen peroxide after the enzymatic breakdown of sugar act antimicrobial . Other molecules that can be present in honey and have antibacterial effects are phenolic compounds, flavonoids, methylglyoxal, and Bee defencin‐1 .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 The application of MGH to a wound can prevent infection and invasion of pathogens by forming a physical shield. 6 Additionally, MGH possesses multiple characteristics that orchestrate its antimicrobial activity, and therefore also has a limited risk for the development of antimicrobial resistance. 3 The acidic pH, the osmotic effect caused by the high sugar content, and the release of hydrogen peroxide after the enzymatic breakdown of sugar act antimicrobial.…”

Section: Introductionmentioning

confidence: 99%

“…3 The acidic pH, the osmotic effect caused by the high sugar content, and the release of hydrogen peroxide after the enzymatic breakdown of sugar act antimicrobial. 1,[6][7][8] Other molecules that can be present in honey and have antibacterial effects are phenolic compounds, flavonoids, methylglyoxal, and Bee defencin-1. 1,3,[9][10][11] Together, these characteristics make MGH effective against a broad range of microorganisms, including those resistant against antibiotics.…”

Section: Introductionmentioning

confidence: 99%

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