The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.

Heinze, Hartmut; Arnold, Hans-Henning; Fischer, Daniela; Kruppa, Joachim

doi:10.1016/s0021-9258(18)68900-8

Cited by 51 publications

(2 citation statements)

References 58 publications

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“…The human RPS6 gene is located on chromosome 9p21, comprises six exons [ 22 ], and encodes a protein of 249 amino acids [ 23 , 24 ]. Contrary to rRNAs, which are transcribed by RNA polymerase I or III, RP genes are transcribed by RNA polymerase II [ 1 ].…”

Section: Regulation Of Rps6mentioning

confidence: 99%

Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

You

Park

et al. 2021

IJMS

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Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been recognized as a surrogate marker for the activated PI3K/AKT/mTORC1 pathway, which occurs in many cancer types. However, downstream mechanisms regulated by RPS6 or p-RPS remains elusive, and the therapeutic implication of RPS6 is underappreciated despite an approximately half a century history of research on this protein. In addition, substantial evidence from RPS6 knockdown experiments suggests the potential role of RPS6 in maintaining cancer cell proliferation. This motivates us to investigate the current knowledge of RPS6 functions in cancer. In this review article, we reviewed the current information about the transcriptional regulation, upstream regulators, and extra-ribosomal roles of RPS6, with a focus on its involvement in cancer. We also discussed the therapeutic potential of RPS6 in cancer.

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Section: Regulation Of Rps6mentioning

confidence: 99%

Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

You

Park

et al. 2021

IJMS

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“…Each has an insert with a size of -0.95 kb, and sequencing showed that the 3' ends of the cDNAs are identical. One cDNA was sequenced on both strands and contains a 744-bp open reading frame, which predicts a polypeptide with -75% identity to the mammalian ribosomal protein S6 sequences (7,14) and -60% identity to the yeast S10 homolog of S6 (21) (Fig. 8).…”

Section: Resultsmentioning

confidence: 99%

Mutations in the Drosophila Gene Encoding Ribosomal Protein S6 Cause Tissue Overgrowth

Stewart

Denell

1993

Molecular and Cellular Biology

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We have characterized two P-element-induced, lethal mutations in Drosophila melanogaster which affect the larval hemocytes, mediators of the insect immune response. Each mutant displays larval melanotic tumors characteristic of mutations affecting the insect cellular immune system, and the moribund animals develop grossly hypertrophied hematopoietic organs because of increased cell proliferation and extra rounds of endoreduplication in some hematopoietic cells. Surprisingly, these mutations are due to P element insertions in the 5' regulatory region of the Drosophila gene encoding ribosomal protein S6 and cause a reduction of S6 transcript abundance in mutant larvae.

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Mitogenesis and protein synthesis: A role for ribosomal protein S6 phosphorylation?

Stewart

Thomas

1994

BioEssays

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It has been known for 20 years that the ribosomal protein S6 is rapidly phosphorylated when cells are stimulated to grow or divide. Furthermore, numerous studies have documented that there is a strong correlation between increases in S6 phosphorylation and protein synthesis, leading to the idea that S6 phosphorylation is involved in up-regulating translation. In an attempt to define a mechanism by which S6 phosphorylation exerts translational control, other studies have focused on characterizing the sites of phosphorylation of this protein and its location within the ribosome. Recent data show that S6 is a protein which may have diverse cellular functions and is essential for normal development, and that it may be involved in the translational regulation of a specific class of messages.

show abstract

The primary structure of the human ribosomal protein S6 derived from a cloned cDNA.

Cited by 51 publications

References 58 publications

Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

Mutations in the Drosophila Gene Encoding Ribosomal Protein S6 Cause Tissue Overgrowth

Mitogenesis and protein synthesis: A role for ribosomal protein S6 phosphorylation?

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