The primary immune response of patients with different stages of squamous-cell bronchial carcinoma.

Jansen, Henk M.; The, T. H.; Gast, G. C. De; Esselink, Mt; Pastoor, G. W.; Orie, N. G. M.

doi:10.1136/thx.33.6.755

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…There also exists a large body of research using molluscan Hcs (again, mostly KLH) as a model protein antigen, which has contributed to the assessment and understanding of immune responses involved in respiratory diseases ( Table S4 ). For example, atopic asthmatics have been shown to produce more serum anti-Hc IgG4 [ 314 ] and IgE [ 30 ] than normal individuals, indicative of an increased/overactive Th 2 response, while administration of molluscan Hcs to patients with respiratory cancer has revealed the immunosuppressive effects of chemotherapy and the disease itself [ 315 , 316 ] ( Table S4 ). Sensitisation to KLH has been found to have an effect that is more-so protective than allergenic [ 317 , 318 ], but serum IL-4 and anti-KLH IgG4 and IgE increase in the presence of diesel exhaust particles [ 319 ], demonstrating the promotion effect of environmental pollutants on allergic airway diseases ( Table S4 ).…”

Section: Molluscan Hemocyanins As Therapeutic Adjuvants and Model mentioning

confidence: 99%

“…Gesheva et al [ 83 , 150 ] carried out two models whereby mice were immunised with influenza hemagglutinin subunit with adjuvant Hcs from H. pomatia (HpH) and R. venosa (RvH; Figure 3 ): although antibody and cytokine profiles varied, HpH produced immunogenic effects comparable to alum (AlOH 2 ); RvH was comparable to KLH and Complete Freund’s Adjuvant, and ultimately superior to KLH in terms of spleenocyte cytotoxicity to virus-infected cells three-months post-immunisation ( Table S3 , Figure 2 ). HpH has also been used effectively as a model antigen in studies of asthma [ 30 , 320 ] and bronchial carcinoma [ 315 ] ( Table S4 ). Hc from the Chilean abalone ( Concholepas concholepas ) is known to have immunogenic properties equal to or better than KLH; it is also commercially available and currently used in a clinical trial as an adjuvant in a prostate cancer vaccine [ 272 ].…”

Section: Molluscan Hemocyanins As Therapeutic Adjuvants and Model mentioning

confidence: 99%

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Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

et al. 2020

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Respiratory diseases place an immense burden on global health and there is a compelling need for the discovery of new compounds for therapeutic development. Here, we identify research priorities by critically reviewing pre-clinical and clinical studies using extracts and compounds derived from molluscs, as well as traditional molluscan medicines, used in the treatment of respiratory diseases. We reviewed 97 biomedical articles demonstrating the anti-inflammatory, antimicrobial, anticancer, and immunomodulatory properties of >320 molluscan extracts/compounds with direct relevance to respiratory disease, in addition to others with promising bioactivities yet to be tested in the respiratory context. Of pertinent interest are compounds demonstrating biofilm inhibition/disruption and antiviral activity, as well as synergism with approved antimicrobial and chemotherapeutic agents. At least 100 traditional medicines, incorporating over 300 different mollusc species, have been used to treat respiratory-related illness in cultures worldwide for thousands of years. These medicines provide useful clues for the discovery of bioactive components that likely underpin their continued use. There is particular incentive for investigations into anti-inflammatory compounds, given the extensive application of molluscan traditional medicines for symptoms of inflammation, and shells, which are the principal molluscan product used in these preparations. Overall, there is a need to target research toward specific respiratory disease-related hypotheses, purify bioactive compounds and elucidate their chemical structures, and develop an evidence base for the integration of quality-controlled traditional medicines.

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Section: Molluscan Hemocyanins As Therapeutic Adjuvants and Model mentioning

confidence: 99%

Section: Molluscan Hemocyanins As Therapeutic Adjuvants and Model mentioning

confidence: 99%

Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

et al. 2020

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Bronchogenic carcinoma: Survival after surgical treatment according to stage, histologic type and immunomorphologic changes in regional lymph nodes

Tosi

Luzi

Leoncini

et al. 1981

Cancer

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The survival rates of 90 patients who underwent operation for bronchogenic carcinoma were analyzed statistically according to sex, age, tumor stage and histologic type, types of surgical procedures (lobectomy or pneumonectomy), and to immunomorphologic parameters of immunologic activity in peribronchial and hilar lymph nodes. The Stage I group survived significantly longer than did the Stage II and III groups, the lobectomized patients survived significantly longer than the pneumonectomized patients. The absence or presence of lymph node metastases was one of the major determinants of survival. The mean values (percent of total node cut surface) of lymph node sinus histiocytosis and of paracortical area could be correlated directly to survival in each of the histologic tumor-type groups, while the development of follicular cortex and germinal centers correlated inversely with survival. Increased survival might be associated with changes concomitant with immune reactivity in lymph node T-cell areas and with the sinus histiocytosis pattern, the latter representing probably a tumor--host reaction of the delayed hypersensitivity type. By contrast, increased activity of lymph node B-cell areas tended to correlate with poor prognosis of lung cancer patients. Moreover, patterns showing germinal center hyperplasia were statistically associated with lymph node neoplastic invasion, while the pattern with sinus histiocytosis and expanded paracortical areas was statistically associated with tumor-free lymph nodes.

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Immunocompetence in Cancer Patients

Karavodin¹,

Golub²

1983

Cancer Treatment and Research

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The primary immune response of patients with different stages of squamous-cell bronchial carcinoma.

Cited by 10 publications

References 21 publications

Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease

Bronchogenic carcinoma: Survival after surgical treatment according to stage, histologic type and immunomorphologic changes in regional lymph nodes

Immunocompetence in Cancer Patients

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