2015
DOI: 10.4103/1947-2714.166216
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The preventive effects of neural stem cells and mesenchymal stem cells intra-ventricular injection on brain stroke in rats

Abstract: Introduction:Stroke is one of the most important causes of disability in developed countries and, unfortunately, there is no effective treatment for this major problem of central nervous system (CNS); cell therapy may be helpful to recover this disease. In some conditions such as cardiac surgeries and neurosurgeries, there are some possibilities of happening brain stroke. Inflammation of CNS plays an important role in stroke pathogenesis, in addition, apoptosis and neural death could be the other reasons of po… Show more

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Cited by 12 publications
(10 citation statements)
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“…Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain . Thus, the intracranial administration of drugs, natural bioactives and cells is utilized by some studies as a primary option for analysis of local effects in specific areas of interest on the brain .…”
Section: Discussionmentioning
confidence: 99%
“…Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain . Thus, the intracranial administration of drugs, natural bioactives and cells is utilized by some studies as a primary option for analysis of local effects in specific areas of interest on the brain .…”
Section: Discussionmentioning
confidence: 99%
“…While conventional therapeutic strategies focus on preventing brain damage, stem cell transplantation has the potential to repair the injured brain tissue. Recently, neural stem cells (NSCs) have been developed and used in preclinical studies as therapy for stroke (3,4).…”
Section: Introductionmentioning
confidence: 99%
“…NSCs reside in specialized microenvironments, or 'niches', that regulate their self-renewal and differentiation activities (13). For example, the continuous production of neuroblasts is maintained by the SVZ microenvironmental niche (3,4). It is widely believed that enhancing the neurogenic activities of endogenous NSCs will provide a much-needed therapeutic option for brain injuries (14).…”
Section: Introductionmentioning
confidence: 99%
“…Noticeable amongst these are neural stem cells (3,4), bone marrow stem cells (3,5,6), cord blood derived MSCs (7,8), adipose tissue derived (5), embryonic stem cells and their derivatives (9), and induced pluripotent stem cells (iPSCs) (10,11). Nevertheless, ease of availability without moral and ethical strings and differentiation capacity to adopt desired phenotype are vital issues for the search of ideal donor cells for transplantation therapy.…”
Section: Original Articlementioning
confidence: 99%