The Preventive Effect of Rofecoxib in Postoperative Intraperitoneal Adhesions

Aldemir, Mustafa; Öztürk, Hayrettin; Erten, Çiğdem; Buyukbayram, H.

doi:10.1080/00015458.2003.11978403

Cited by 31 publications

(25 citation statements)

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“…Examples include antimicrobials, nonsteroidal anti-inflammatory drugs, heparin, opioids, chemokines, and physical barriers, such as the combination of hyaluronic acid and carboxymethylcellulose [10][11][12][13][14][15] . In our study, we used simvastatin, which is an 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, used as a lipidlowering agent in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Even with optimal surgical techniques taking the above-mentioned rules into consideration, trauma to the peritoneum is inevitable. Thus, many clinical and experimental studies have been performed to examine meth-99 ods of preventing adhesions, such as the use of antimicrobials, nonsteroidal anti-inflammatory drugs, heparin, opioids, chemokines, and physical barriers, such as the combination of hyaluronic acid and carboxymethylcellulose [10][11][12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

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The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

Küçük¹,

Kaptanoğlu²,

Kurt³

et al. 2007

Eur Surg Res

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Aim: The aim of this study is to show the effect of simvastatin on intra-abdominal adhesion formation. Method: Adhesion formation was achieved by scratching the cecum and anterior abdominal wall following median laparotomy. Three different groups of 10 rats each were formed. In group I, 0.57 mg/kg/day simvastatin was injected intraperitoneally right after the operation and for 5 days thereafter. In group II, an equal dose of simvastatin to that used in group I was given via gavage. A physiological saline solution was given to group III for the same period of time. On the 6th and 14th day, blood samples were taken and peritoneal lavage was performed to measure the tissue-type plasminogen activator (t-PA) activity. Adhesions were graded via re-laparotomies on the 14th day after the first operation. Results: The adhesion scores were 1.40 ± 0.22, 1.50 ± 0.26, and 2.90 ± 0.34 in groups I, II, and III, respectively (p = 0.007), and the score was higher in group III than in the other groups (p = 0.005, p = 0.011). Conclusion: Intraperitoneal simvastatin application decreases adhesion formation by increasing the t-PA level in abdominal surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

Küçük¹,

Kaptanoğlu²,

Kurt³

et al. 2007

Eur Surg Res

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show abstract

“…Therefore, applying proper strategies to prevent adhesions formation should be considered in all clinical and surgical settings. Several preventive methods and potential preventive agents have been studied, including lavage of abdominal cavity, lytic agents, macrophage promoting factors, nonsteroidal anti-nflammatory drugs, heparin, dextran 70, ringer lactate, antihistamine, prostaglandin synthesis inhibitors, calcium channel blockers, rofecoxib, and green tea extract [4][5][6][7][8] . These agents may indirectly prevent the creation of adhesions by inhibiting inflammatory processes leading to adhesion formation, or may act as physical barriers in separating injured surfaces 9 .…”

Section: ■ Introductionmentioning

confidence: 99%

The effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative peritoneal adhesion formation in rats

et al. 2017

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Purpose: To assess the effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative adhesion in animal models. Methods: Sixty males Albino Wistar rats aged 5 to 6 weeks were classified into five groups receiving none, heparin, PRP, silver nanoparticles, PRP plus silver nanoparticles intraperitoneally. After 2 weeks, the animals underwent laparotomy and the damaged site was assessed for peritoneal adhesions severity. Results: The mean severity scores were 2.5 ± 0.9, 2.16 ± 0.7, 1.5 ± 0.5, 2.66 ± 0.88, and 2.25 ± 0.62 in the control, heparin, PRP, silver and PRP plus silver groups, respectively with significant intergroup difference (p = 0.004). The highest effective material for preventing adhesion formation was PRP followed by heparin and PRP plus silver. Moreover, compared to the controls, only use of PRP was significantly effective, in terms of adhesion severity (p = 0.01). Conclusion: Platelet-rich plasma alone may have the highest efficacy for preventing postoperative peritoneal adhesions in comparison with heparin, silver nanoparticles and PRP plus silver nanoparticles.

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“…Therefore, some clinical trials were conducted because of this hypothesis and the result of a variety of drugs, including steroids, non-selective and selective cyclooxygenase inhibitors, 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors (Statins), and tissue-plasminogen activator were inquired. However, still none of these meet the desired outcomes [23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats

Sanei¹,

Shariati²,

Zare³

et al. 2014

Int J Hepatobiliary Pancreat Dis

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Aims: the purpose of this study was to assess the efficacy of prednisolone and cellcept in decreasing postoperative adhesion band formation in rats. Methods: sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rat, then 2 mL of 10% sterile solution talc was injected into intraperitoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral cellcept (40 mg/kg/d) and group 3 received oral Prednisolone (5 mg/kg/d) for 4 weeks. results: the formation of adhesion bands in control group was significantly higher than the prednisolone and cellcept group (p <0.001). the amount of adhesion bands in the second group was similar to the third one. conclusion: Orally administered cellcept is as effective as oral prednisolone in declining chance of intraperitoneal adhesion band formation, although it causes fewer complications such as infection in rats.

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The Preventive Effect of Rofecoxib in Postoperative Intraperitoneal Adhesions

Abstract: We were of the opinion that Rofecoxib, the selective cyclo-oxygenase inhibitor, was effective in the prevention of postoperative peritoneal adhesions.

Cited by 31 publications

References 0 publications

The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

The Role of Simvastatin on Postoperative Peritoneal Adhesion Formation in an Animal Model

The effectiveness of heparin, platelet-rich plasma (PRP), and silver nanoparticles on prevention of postoperative peritoneal adhesion formation in rats

Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats

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