The Preventive Effect of Oral EGCG in a Fetal Alcohol Spectrum Disorder Mouse Model

Long, Ling; Li, Yang; Wang, Yi Dong; He, Qing-Yu; Li, Mei; Cai, Xiao Dong; Peng, Kou Cheng; Li, Xiang Pen; Xie, Dan; Wen, Yan; Yin, De Ling; Peng, Ying

doi:10.1111/j.1530-0277.2010.01282.x

Cited by 28 publications

(27 citation statements)

References 35 publications

(48 reference statements)

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“…Studies from Yang et al have indicated that maternal green tea EGCG prevents hyperglycemia-induced embryonic vasculopathy and malformation via inhibition of oxidative stress signaling (83). A similar work by Long et al indicated that consumption of green tea prevents ethanol-induced embryonic growth retardation (84). These studies provide insights that a diet rich in chemopreventive compounds consumed early in life may modulate the genetic/epigenetic profiles to confer beneficial effects against the risk of developing several types of diseases later in life.…”

Section: Epigenetic Regulations During Embryogenesismentioning

confidence: 88%

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Saldanha

Tollefsbol

2013

AAPS J

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The etiology of most human diseases involves complicated interactions of multiple environmental factors with individual genetic background which is initially generated early in human life, for example, during the processes of embryogenesis and fetal development in utero. Early embryogenesis includes a series of programming processes involving extremely accurate time-controlled gene activation/silencing expressions, and epigenetic control is believed to play a key role in regulating early embryonic development. Certain dietary components with properties in influencing epigenetic processes are believed to have preventive effects on many human diseases such as cancer. Evidence shows that in utero exposure to certain epigenetic diets may lead to reprogramming of primary epigenetic profiles such as DNA methylation and histone modifications on the key coding genes of the fetal genome, leading to different susceptibility to diseases later in life. In this review, we assess the current advances in dietary epigenetic intervention on transgenerational human disease control. Enhanced understanding of the important role of early life epigenetics control may lead to cost-effective translational chemopreventive potential by appropriate administration of prenatal and/or postnatal dietary supplements leading to early disease prevention.

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Section: Epigenetic Regulations During Embryogenesismentioning

confidence: 88%

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Saldanha

Tollefsbol

2013

AAPS J

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“…For instance, peptides that can antagonize ethanol-induced inhibition of L1 cell adhesion molecule have been tested in vitro and in vivo [184,185]; antioxidants, including superoxide dismutase [186], vitamin C [187], vitamin E [188], and green tea extract [189], have been shown to protect against ethanol-induced oxidative stress in FASD animal models. NEURODEVELOPMENTAL DISORDERS in preclinical models.…”

Section: Experimental Treatments For Fasdmentioning

confidence: 99%

Fetal Alcohol Spectrum Disorders

Guizzetti¹

2015

Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders

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“…Reactive oxygen species (ROS) progressed in prenatal alcohol exposure embryos (Henderson et al, 1995; Heaton et al, 2002). Malondialdehyde (MDA) and hydrogen peroxide (H2O2) are linked to nervous injury induced by alcohol (Long et al, 2010; Peng et al, 2005). Yet there are no effective treatments against FASD other than ethanol abstention (Long et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Malondialdehyde (MDA) and hydrogen peroxide (H2O2) are linked to nervous injury induced by alcohol (Long et al, 2010; Peng et al, 2005). Yet there are no effective treatments against FASD other than ethanol abstention (Long et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress

Zhang

Wang

et al. 2018

Intl J of Devlp Neuroscience

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By now interventions against fetal alcohol spectrum disorder targeting oxidative stress includes astaxanthin, Ascorbic acid (Vitamin C), Vitamin E, beta-carotene, (-)-Epigallocatechin-3-gallate (EGCG), Omega-3 fatty acids, etc (see Fig. 1). However, most interventions are only assayed in animal models, more clinical trials are needed to show whether antioxidants make an effort against FASD damage.

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The Preventive Effect of Oral EGCG in a Fetal Alcohol Spectrum Disorder Mouse Model

Abstract: In a murine model, oxidative stress appears to play an important role in ethanol-induced embryonic growth retardation. EGCG can prevent some of the embryonic injuries caused by ethanol.

Cited by 28 publications

References 35 publications

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Impact of Epigenetic Dietary Compounds on Transgenerational Prevention of Human Diseases

Fetal Alcohol Spectrum Disorders

A review of interventions against fetal alcohol spectrum disorder targeting oxidative stress

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