The Prevention of Headache

Peatfield, Richard

doi:10.1007/978-1-4471-3127-4_11

Cited by 3 publications

(1 citation statement)

References 91 publications

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“…Severe and sometimes fatal anaphylactic reactions to peanuts have recently been a major cause for concern [lo]. A common adverse reaction to food is migraine caused by the consumption of red wine (attributed to the polyphenolic material extract from the grape skins) or drinks containing methylxanthines (coffee and tea) [11,12].…”

Section: Idiosyncratic Responses To Foodsmentioning

confidence: 99%

Overview of bioactive compounds in foods

Sanders

1996

Biochemical Society Transactions

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Section: Idiosyncratic Responses To Foodsmentioning

confidence: 99%

Overview of bioactive compounds in foods

Sanders

1996

Biochemical Society Transactions

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Überblick zur Rolle der 5-HT2-Rezeptorantagonisten in der Migränetherapie

Mylecharane¹,

Ensink²

1994

Migräne

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5-HT2 receptor antagonists and migraine therapy

1991

J Neurol

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5-Hydroxytryptamine (5-HT; serotonin) has been implicated in the pathophysiology of migraine, and several drugs with potent 5-HT2 receptor blocking activity (methysergide, pizotifen, cyproheptadine and mianserin) have been recognized as being clinically effective in migraine prophylaxis, although the selective 5-HT2 receptor antagonist ketanserin (the principal agent used to identify 5-HT2 receptor-mediated actions) seems to be ineffective in migraine. Pizotifen is the most widely used 5-HT2 receptor antagonist in migraine prophylaxis, because of its superior efficacy compared with cyproheptadine, and because the incidence and severity of adverse effects with pizotifen is lower compared with methysergide and mianserin. These agents have additional antagonistic effects at histamine H1, muscarinic cholinergic, alpha 1-adrenergic, alpha 2-adrenergic and dopamine receptors, but drugs which are selective for these non-5-HT receptors appear to be of no benefit in migraine. Actions mediated by 5-HT2 receptors which could be of relevance to migraine comprise cranial vasoconstriction, increased cranial capillary permeability and platelet aggregation, and some central nervous system effects and neuroendocrine functions. Although pizotifen, cyproheptadine and mianserin are considered to be relatively specific for 5-HT2 receptors, these agents and methysergide all share a high affinity for 5-HT1C binding sites; ketanserin, however, has little affinity for these sites, thus activation of 5-HT1C receptors may be an important step in the pathogenesis of migraine. It is not yet known which 5-HT1C receptor-mediated actions of 5-HT are relevant to migraine, but some behavioural actions and cranial vasodilatation via release of endothelium-derived relaxing factor may be involved.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Prevention of Headache

Cited by 3 publications

References 91 publications

Overview of bioactive compounds in foods

Overview of bioactive compounds in foods

Überblick zur Rolle der 5-HT2-Rezeptorantagonisten in der Migränetherapie

5-HT2 receptor antagonists and migraine therapy

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