The Prevention Of Experimental Clostridium Novyi Gas Gangrene In High-VelociTy Missile Wounds By Passive Immunisation

Boyd, N. A.; Walker, P. D.; Thomson, Robert

doi:10.1099/00222615-5-4-459

Cited by 12 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We suspected that the cause of death was the release of potent lethal toxins from the bacteria germinating within the tumors. Indeed, other anaerobic bacterial spores have proved highly toxic to animals and humans following germination within the anaerobic environments present in tumors or wounds, and the resultant mortality was shown to be due to specific secreted toxins (22)(23)(24)(25)(26).…”

Section: Infiltration Of the Tumor Mass Following IV Injection Of Cmentioning

confidence: 99%

Combination bacteriolytic therapy for the treatment of experimental tumors

Dang

Bettegowda

Huso

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

492

488

View full text Add to dashboard Cite

Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized compartments of tumors. We have here systematically assessed anaerobic bacteria for their capacity to grow expansively within avascular compartments of transplanted tumors. Among 26 different strains tested, one (Clostridium novyi) appeared particularly promising. We created a strain of C. novyi devoid of its lethal toxin (C. novyi-NT) and showed that intravenously injected C. novyi-NT spores germinated within the avascular regions of tumors in mice and destroyed surrounding viable tumor cells. When C. novyi-NT spores were administered together with conventional chemotherapeutic drugs, extensive hemorrhagic necrosis of tumors often developed within 24 h, resulting in significant and prolonged antitumor effects. This strategy, called combination bacteriolytic therapy (COBALT), has the potential to add a new dimension to the treatment of cancer.

show abstract

Section: Infiltration Of the Tumor Mass Following IV Injection Of Cmentioning

confidence: 99%

Combination bacteriolytic therapy for the treatment of experimental tumors

Dang

Bettegowda

Huso

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

492

488

View full text Add to dashboard Cite

show abstract

“…Several early studies showed that a formaldehyde toxoid of the a-toxin purified from Cl. perfringens was able to induce protection against gas gangrene (Boyd et al 1972;Kameyama et al 1975) but it is likely that these preparations also contained small quantities of other toxoided proteins making the interpretation of these studies difficult. Two recent investigations have demonstrated that the soluble factor proposed by McNee and Dunn (1917) is the a-toxin.…”

Section: Invasion and Growthmentioning

confidence: 99%

Bacterial Phospholipases

Titball¹,

Rood²

2000

Bacterial Protein Toxins

View full text Add to dashboard Cite

“…First, microbiologically, C. novyi is a motile, spore-forming, and obligate anaerobe that can cause gas gangrene [36,37]. Although it has not been fully understood so far, three possible explanations are possible.…”

Section: The Selection Of Nontoxigenic Clostridium Novyimentioning

confidence: 99%