The prevention and treatment of chemotherapy-induced nausea and vomiting in children and adolescents receiving cancer treatment: the current status and possibilities for improvement

Жуков, Н. В.; Казакова, Л. Л.; Novichkova, Galina

doi:10.24287/1726-1708-2020-19-4-205-223

Voprosy gematologii/onkologii i immunopatologii v pediatrii

2020

DOI: 10.24287/1726-1708-2020-19-4-205-223

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The prevention and treatment of chemotherapy-induced nausea and vomiting in children and adolescents receiving cancer treatment: the current status and possibilities for improvement

Н. В. Жуков

Л. Л. Казакова

Galina Novichkova

Abstract: Even though chemotherapy-induced nausea and vomiting (CINV) rarely become life-threatening, they are regarded by patients as one of the most unbearable complications and can often cause great suffering. CINV may also be an aggravating factor for other complications and pathological conditions. The currently available antiemetic prophylaxis can greatly reduce the incidence of CINV in children and adolescents receiving cancer treatment. However, inadequate management of CINV is still much more common in children… Show more

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2022

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Cited by 2 publications

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The chemotherapy-induced nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. Hidden problem

Rabaeva

Жуков

2022

Ross. ž. det. gematol. onkol.

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Introduction. Despite significant advances in prevention, chemotherapy-induced (cytostatic therapy) nausea and vomiting (CINV) continues present a significant clinical problem for patients oncohematological profile, while often remaining outside areas of attention of pediatric oncologists and hematologists.The aim of the study – frequency comparison of occurrence CINV according to data obtained from the medical database documentation (retrospective group) and data obtained in the process assessment of CINV using a modified questionnaire and specialized scales (prospective group).Materials and methods. The retrospective group included 52 patients who received 178 cycles of highly emetogenic anticancer therapy with standard antiemetic prophylaxis from 02/01/2020 to 08/01/2020, in prospective – 88 patients who received 456 cycles of a similar anticancer therapy with standard CINV prophylaxis from 10/01/2020 until 07/01/2021.Results. Although the groups were comparable in terms of key patient characteristics, chemotherapy regimens, and regimen prevention of CINV, the frequency of complete control of CINV between them is significantly was different: when analyzing the primary documentation, it turned out that the complete control of CINV in the acute, delayed and general periods is observed in 82 %, 86 %, 82 % cycles, while when assessing CINV using specialized questionnaires, the absence of these complications was noted only in 68 %, 52 %, 43 % of cycles. Thus, if we focus on standard tools fixing complications (diary entries, prescription lists), in more than 80 % of children receiving highly emetogenic cytostatic therapy it is possible to achieve complete control of CINV, and this complication does not really pose a clinically significant problem. However, when using a questionnaire and specialized scales, it becomes obvious that that more than half of children continue to suffer from CINV despite the standard prophylaxis of this complication.Conclusion. In this way, the analysis performed shows that the frequency of development of CINV during routine antiemetic prophylaxis is clearly underestimated, and, in part, due to this CINV and remains outside the attention of pediatric oncologists and hematologists. For an adequate assessment of the true incidence of CINV and, accordingly, determining the need for improvement of existing approaches to their prevention, a key role should be played specialized questionnaires and scales that fully allow “visualize” this complication.

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The chemotherapy-induced nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. Hidden problem

Rabaeva

Жуков

2022

Ross. ž. det. gematol. onkol.

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Nasopharyngeal carcinoma in children and adolescents: a literature review and our own data

Жуков

Rabaeva

2022

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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Nasopharyngeal carcinoma (NPC) is one of the few epithelial tumors that regularly occur in the pediatric population. The majority of patients with localized and locally advanced NPC can be cured with current treatment protocols which include platinum-based induction therapy followed by chemoradiation therapy. The prognosis of patients with initially metastatic NPC and recurrent disease after prior curative treatment is, however, still unfavorable. Fortunately, new treatment options such as immune checkpoints inhibitors and supportive treatment with oral fluoropyrimidine give hope for better outcomes in these patients as well. It's important to note that the management of NPC diagnosed in adults and children allows for the adaptation of effective treatment approaches for either of the age groups. An analysis of our own data suggests that current treatment protocols for NPC can be successfully adopted by Russian clinics and can help to achieve treatment outcomes comparable to the results obtained in other countries. The purpose of this article is to overview current therapeutic approaches for NPC and possible ways of their improvement based on our own and literature data. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.

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The prevention and treatment of chemotherapy-induced nausea and vomiting in children and adolescents receiving cancer treatment: the current status and possibilities for improvement

Cited by 2 publications

References 63 publications

The chemotherapy-induced nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. Hidden problem

The chemotherapy-induced nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. Hidden problem

Nasopharyngeal carcinoma in children and adolescents: a literature review and our own data

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