The prevention and treatment of cerebral ischemia

Lanier, William L.

doi:10.1007/bf03013181

Cited by 26 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[61,62] Disruption of coupling of blood flow to neuronal activation, results in impairment of normal synaptic communication among neurons that underlie normal learning and memory process. [63,64] This reduced brain energy metabolism as a result of chronic hypoperfusion induces microglial activation and reactive astrocytosis. [65] Though microgliosis is evident from 15 th day onwards, more pronounced changes are seen after 28 days.…”

Section: Discussionmentioning

confidence: 99%

Role ofCentella asiaticaon cerebral post-ischemic reperfusion and long-term hypoperfusion in rats

et al. 2009

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Role ofCentella asiaticaon cerebral post-ischemic reperfusion and long-term hypoperfusion in rats

et al. 2009

View full text Add to dashboard Cite

“…One of the goals in treating cerebral ischemia is to increase cerebral perfusion pressure and blood O 2 content with the use of supplemental O 2 [3]. For this reason, hyperbaric oxygen (HBO 2 ) therapy has recently been considered to offer new possibilities of recovery for patients with brain injury.…”

Section: Introductionmentioning

confidence: 99%

Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury

Hardy

Johnston

Beaumont

et al. 2007

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Corticosteroids have also been studied as agents for neuroprotection because they reduce body's inflammatory response, which could reduce the incidence of POCD and benefit in ischemic stroke and encephalopathy [53]. In spite of that, corticosteroids may also cause atrophy, neurotoxicity, neuroendangerment, and hyperglycemia after administration [54].…”

Section: Pharmacological Neuroprotection In Cardiac Surgerymentioning

confidence: 99%

Neuroprotection against stroke and encephalopathy after cardiac surgery

Jovin

Katlaps

Ellis

et al. 2019

Interventional Medicine and Applied Science

View full text Add to dashboard Cite

Cerebral ischemia in the perioperative period is a major risk factor for stroke, encephalopathy, and cognitive decline after cardiothoracic surgery. After coronary artery bypass grafting, both stroke and encephalopathy can result in poor patient outcomes and increased mortality. Neuroprotection aims to lessen the severity and occurrence of further injury mediated by stroke and encephalopathy and to aid the recovery of conditions already present. Several pharmacological and non-pharmacological methods of neuroprotection have been investigated in experimental studies and in animal models, and, although some have shown effectiveness in protection of the central nervous system, for most, clinical research is lacking or did not show the expected results. This review summarizes the value and need for neuroprotection in the context of cardiothoracic surgery and examines the use and effectiveness of several agents and methods with an emphasis on clinical trials and clinically relevant neuroprotectants.

show abstract

The prevention and treatment of cerebral ischemia

Cited by 26 publications

References 33 publications

Role ofCentella asiaticaon cerebral post-ischemic reperfusion and long-term hypoperfusion in rats

Role ofCentella asiaticaon cerebral post-ischemic reperfusion and long-term hypoperfusion in rats

Pilot case study of the therapeutic potential of hyperbaric oxygen therapy on chronic brain injury

Neuroprotection against stroke and encephalopathy after cardiac surgery

Contact Info

Product

Resources

About