The Prevention and Treatment of Vascular Graft Infection With a Triclosan (Irgasan®)-bonded Dacron Graft:an Experimental Study in the Pig

Abstract

in this animal model Triclosan bonding appears effective in preventing prosthetic graft infection. However, the in situ replacement of Triclosan-protected grafts was not successful in the treatment of graft infection.

Polyester vascular prostheses coated with a cyclodextrin polymer and activated with antibiotics: Cytotoxicity and microbiological evaluation

“…Hernandez et al [10] reported that triclosan restricted infections well, but this solution was not applicable to the replacement of infected prostheses or high-level infections. In addition, triclosan is on the list of compounds known for their inducement of bacterial resistance, and therefore should not be authorized on implantable biomedical devices.…”

Current options in prosthetic vascular graft infection: comparative analysis of 63 consecutive cases

“…Although the initial results seemed to confirm the usefulness of rifampicin-impregnated [13], silver-impregnated or triclosan-impregnated [14] grafts in the treatment of limited vascular prosthetic graft infections, larger studies have shown that the results of treatment with rifampicin-impregnated grafts are unsatisfactory in cases of MRSA, fungi and rifampicin-resistant Staphylococcus epidermidis. These infections were responsible for a 16%-35% mortality rate in studies by Bandyk et al [13] and Hayes et al [15].…”

Physical and Functional Comparison of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 Suture with Triclosan) with Coated VICRYL* Suture (Coated Polyglactin 910 Suture)

“…The potential of such measures was demonstrated recently in vascular prosthetic grafts [9]. In this study, triclosan was bonded to a graft material, applied to the femoral arteries of 51 pigs, and the grafts infected with S. aureus (2 ϫ 10 7 colonyforming units/mL).…”